Journal of Prosthetic Dentistry, Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
Язык: Английский
Biomimetics, Год журнала: 2024, Номер 9(3), С. 153 - 153
Опубликована: Март 1, 2024
The rehabilitation of alveolar bone defects moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, guided regeneration technique combined with various grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, dimensional stability. Thus, development biomimetic scaffolds tailor-made characteristics that can modulate cell tissue interaction may be a promising tool. This article presents critical consideration in scaffold’s design while also providing information on fabrication methods nanosystems. Their utilization delivery systems will mentioned.
Язык: Английский
Процитировано
11
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(22), С. 6962 - 6962
Опубликована: Ноя. 7, 2023
Guided bone regeneration (GBR) is a promising technique in tissue engineering that aims to replace lost or injured using resorbable scaffolds. The promotion of osteoblast adhesion, migration, and proliferation greatly aided by GBR materials, surface changes are critical imitating the natural structure improve cellular responses. Moreover, interactions between bioresponsive scaffolds, growth factors (GFs), immune cells, stromal progenitor cells essential promoting regeneration. This literature review comprehensively discusses various aspects scaffolds engineering, encompassing scaffold design, fabrication techniques, advanced manufacturing methods, including three-dimensional printing. In addition, this explores modifications replicate native structures their impact on mechanisms described, providing information how GFs, orchestrate healing. Practical applications clinical settings presented underscore importance these principles integration, healing, Furthermore, delves into emerging areas metamaterials artificial intelligence regenerative medicine. These interdisciplinary approaches hold immense promise for furthering improving therapeutic outcomes, leading enhanced patient well-being. potential combining material science, manufacturing, biology showcased as pathway advance addressing variety needs challenges. By comprehensive narrative, detailed, up-to-date account scaffolds' role transformative offered.
Язык: Английский
Процитировано
19
Clinical Oral Implants Research, Год журнала: 2024, Номер 35(11), С. 1452 - 1466
Опубликована: Авг. 6, 2024
Examine the histomorphometric bone composition, following alveolar ridge preservation techniques and unassisted socket healing.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135338 - 135338
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
4
Periodontology 2000, Год журнала: 2023, Номер 94(1), С. 627 - 638
Опубликована: Сен. 28, 2023
The aim of this study was to investigate the biological outcomes bone-level implants restored with long vs. short abutments, regard 'one abutment at one time' protocol. systematic search performed in five databases: MEDLINE (PubMed), EMBASE, Web Science, Scopus, and CENTRAL for randomized controlled trials up January 14, 2023. Data were collected marginal bone loss, bleeding on probing, probing pocket depth by two reviewers. As effect size measure, mean difference (MD), risk ratio (RR) used continuous categorical outcomes, R-statistics software conducting statistical analyses. For quality certainty assessment, Risk Bias Tool 2, ROBINS-I, GRADE approach used. resulted 4055 records without any duplicates. After title, abstract, full-text analysis, eight articles found eligible inclusion. Bone-level platform-switched presented less loss after 6 months 1 year as well, when abutments (MD 0.63, 95% CI: [-0.16; 1.42]) 0.26, [-0.02; 0.53]). However, subgroup analysis revealed no applying protocol (p = 0.973). Bleeding similarly good results both groups almost differences (RR 0.97, [0.76; 1.23]) -0.05, [-1.11; 1.01]). Longer seem be a favorable choice decreasing early irrespective connection timing.
Язык: Английский
Процитировано
10
Clinical Oral Implants Research, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
ABSTRACT Objectives To evaluate the 1‐ to 5‐year outcomes of dental implants placed with tenting screw (TS) technique and compare their clinical efficacy conventional guided bone regeneration (GBR). Methods This retrospective study involved TS or GBR technique. Horizontal volumetric gains were evaluated by reconstructing cone‐beam computed tomography (CBCT) data. Complications, biological parameters, esthetic scores, patients' satisfaction recorded. Results A total 75 in 42 patients (20 defect sites group 22 group) included this study. With a follow‐up, no failed, resulting 100% implant survival rate. After healing periods, demonstrated horizontal 2.85 ± 1.42 mm, 3.37 1.79 3.27 1.68 mm at 1, 3, 5 below shoulder, significantly exceeding ( p = 0.009, 0.002, respectively). Consistently, three‐dimensional resorption rates for groups after periods 16.5% 29.3% < 0.001), increasing 36.7% 50.7% follow‐up 0.001). The overall PPDs smaller than those (2.50 (2.25, 2.50) vs. 2.50 2.75) 0.038). No other significant differences observed terms peri‐implant soft tissue health, esthetics, satisfaction. Conclusions Considering superior augmentation comparable patient technique, emerges as reliable treatment option atrophic alveolar ridges anterior maxilla.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Abstract During the bone tissue repair process, highly dynamic interactions between host and materials hinder precise, stable, sustained immune modulation. Regulating response based on potential mechanisms of macrophage phenotypic changes may represent an effective strategy for promoting healing. This study successfully constructs a co‐dispersed pFe₃O₄‐MXene nanosystem by loading positively charged magnetite (pFe₃O₄) nanoparticles onto MXene nanosheets using electrostatic self‐assembly. Subsequently, this work fabricates biomimetic porous scaffold (PFM) via selective laser sintering, which exhibit superior magnetic properties, mechanical performance, hydrophilicity, biocompatibility. Further investigations demonstrate that PFM could precisely remotely modulate polarization toward M2 phenotype under static field, significantly enhancing osteogenesis angiogenesis. Proteomic analysis reveal upregulates Arg2 expression, mitochondrial function accelerating oxidative phosphorylation, thereby inducing transition. In vivo experiments validated scaffold's regulatory capacity in subcutaneous cranial defect repairs rats, effectively new formation. Overall, modulation targeting metabolism offers novel insights material design engineering regenerative medicine.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way
Язык: Английский
Процитировано
0
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 187 - 210
Опубликована: Март 28, 2025
This chapter explores the transformative impact of personalized dental care on modern oral health practices. By moving beyond standardized approaches, dentistry leverages genetic screening, lifestyle analysis, and environmental factors to create tailored treatment plans for patients. The integration markers in risk assessments enables early intervention conditions such as periodontal disease, while patient-specific strategies enhance efficacy compliance. Additionally, advent big data predictive analytics, powered by artificial intelligence, has revolutionized decision-making offering real-time insights precise outcomes. However, also delves into ethical dimensions these advancements, addressing critical issues patient privacy, security, informed consent.
Язык: Английский
Процитировано
0