Cells,
Год журнала:
2024,
Номер
13(23), С. 1970 - 1970
Опубликована: Ноя. 28, 2024
Due
to
its
antimicrobial,
anti-inflammatory
and
pro-healing
properties,
the
application
of
cold
atmospheric
plasma
(CAP)
has
emerged
as
a
new
promising
therapeutic
strategy
in
various
fields
medicine,
including
general
medicine
dentistry.
In
this
light,
aim
present
study
was
investigate
effects
homemade
jet
on
cellular
behaviour
two
important
cell
types
involved
gingivitis,
namely
gingival
fibroblasts
(HGF-1
line)
macrophages
(RAW
264.7
line),
by
direct
CAP
different
experimental
conditions.
The
HGF-1
cells
investigated
terms
viability/proliferation
(LIVE/DEAD
CCK-8
assays),
morphological
features
(immunofluorescent
staining
actin
cytoskeleton)
fibronectin
expression
(immunocytochemical
network),
while
macrophages’
response
evaluated
through
assessment
survival/proliferation
rate
inflammatory
activity
(pro-inflammatory
cytokine
secretion
profile
(ELISA
assay)
foreign
body
giant
(FBGCs)
formation
cytoskeleton
multinuclearity
index
determination)).
vitro
biological
revealed
an
upward
trend
dependent
treatment
time
number
applications,
proliferation
(p
<
0.0001)
0.0001).
On
other
hand,
exposed
five
consecutive
applications
for
longer
times
(over
120
s)
exhibited
strong
pro-inflammatory
activity,
evinced
their
altered
morphology,
FBGCs
formation.
Overall,
our
results
demonstrate
that
exposure,
when
used
with
appropriate
operating
parameters,
beneficial
effect
RAW
cells,
thus
paving
way
further
vivo
investigations
will
allow
translation
from
research
clinic
alternative
therapy
gingivitis.
Periodontology 2000,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Abstract
To
provide
a
comprehensive
and
updated
mapping
of
observational
studies
assessing
the
relationship
between
periodontitis
systemic
diseases
through
bibliometric
visual
analysis.
A
search
was
conducted
using
Web
Science
database,
covering
period
1989
to
2024.
The
Medical
Subject
Headings
(MeSH)
from
US
National
Library
Medicine
used
categorize
conditions,
focusing
on
terms
unrelated
stomatognathic
diseases.
analysis
included
keyword
co‐occurrence
mapping,
co‐authorship,
bibliographic
coupling,
co‐citation
Quality
indicators
such
as
silhouette
score,
modularity,
centrality
were
considered
assess
network's
quality.
research
strategy
identified
6106
records,
which
1519
met
inclusion
criteria.
revealed
that
46.73%
literature
topic
published
in
last
5
years
annual
publication
trend
peaked
2023.
Nutritional
&
Metabolic
Diseases
(
n
=
398),
Cardiovascular
335),
Female
Urogenital
Pregnancy
Complications
244),
Musculoskeletal
182)
most
representative
categories
associated
with
periodontitis.
co‐cited
journals
Journal
Periodontology
1412),
Clinical
1343),
Dental
Research
940),
2000
849).
USA,
China,
Brazil,
Sweden
countries
contributed
number
publications.
present
study
growing
evaluating
association
diseases,
highlighting
negative
impact
plethora
conditions
rising
translational
interest
this
relationship.
With
an
aging
population,
is
expected
affect
people
coming
decades,
presenting
significant
challenges
public
health.
Improved
knowledge
is,
therefore,
essential
enable
more
care,
preventive
strategies,
optimal
oral
health
for
patients
Journal of Periodontology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
To
investigate
the
effect
of
rheumatoid
arthritis
(RA)
on
incidence
peri-implantitis
(PI)
and
peri-implant
mucositis
(PIM).
Radiographic
clinical
chart
reviews
were
conducted
to
measure
probing
depth
(PD),
bleeding
probing,
marginal
bone
loss
(MBL)
around
implants
diagnose
diseases
based
2017
workshop
classification.
Values
recorded
at
baseline
(T0)
last
available
radiograph
(T1).
Maintenance
compliance
was
evaluated.
Cases
followed
longitudinally
detect
PI
PIM.
Various
potential
confounders
controlled,
including
total
radiographic
follow-up
time,
chart-based
number
maintenance
visits,
implant
dimensions,
history
periodontitis,
graft,
restoration
angle,
emergence,
smoking,
diabetes
mellitus.
Chi-square
Mann-Whitney
tests
evaluated
categorical
continuous
differences.
Generalized
estimating
equations
with
a
Tweedie
distribution
applied.
Binary
logistic
regression
ascertained
odds
ratio
for
binary
outcomes.
A
101
patients
(50
RA
51
non-RA)
124
investigated.
The
mean
period
5.38
±
2.22
years.
Implant
survival
rate
high
96%.
group
demonstrated
significantly
higher
(p
=
0.024),
while
non-RA
showed
PIM
<
0.001).
No
significant
differences
observed
between
both
groups
in
MBL.
Compared
group,
similar
MBL
rates
lower
PIM;
however,
there
PI.
In
this
study,
we
investigated
condition
dental
50
compared
healthy
controls
over
5
Assessments
from
initial
treatment
visit
included
reviewing
patient
records
radiographs
signs
bleeding,
depth,
loss.
These
measures
helped
(PIM)
periodontal
disease
findings
revealed
(96%)
no
difference
However,
than
that
Diagnostics,
Год журнала:
2025,
Номер
15(8), С. 990 - 990
Опубликована: Апрель 14, 2025
Background/Objectives:
Peri-implantitis
is
a
prevalent
inflammatory
condition
affecting
dental
implants,
leading
to
increased
treatment
costs,
patient
dissatisfaction,
and
potential
implant
failure.
Novel
biomarker-based
approaches
may
contribute
early
detection,
thereby
decreasing
the
burden
of
disease.
The
aim
this
review
was
assess
in
vivo
studies
using
metabolomics
identify
metabolic
profiles
biomarkers
peri-implantitis.
Methods:
protocol
for
study
registered
with
PROSPERO
(CRD42025634865).
Five
databases
grey
literature
sources
(PubMed,
Scopus,
Web
Science,
ProQuest,
Google
Scholar)
were
searched
keywords
related
Studies
selected
by
independent,
inter-calibrated
researchers.
Data
extracted
predefined,
custom
forms.
risk
bias
assessed
ROBINS-I
tool.
Results:
An
electronic
search
retrieved
543
articles,
which
five
selected.
All
published
within
last
years
search.
but
one
used
untargeted
metabolomics,
all
identified
metabolites
associated
peri-implantitis
or
distinct
metabolomic
SCFAs
lysine
recurring
results,
confirming
findings
previous
on
periodontal
Conclusions:
Metabolomics
has
not
been
widely
Evidence
from
existing
confirms
periodontitis.
Several
PI
are
immune
response,
tissue
degradation,
cellular
energy
pathways.
Integrating
-omics
technologies
into
diagnosis
facilitate
biomarker
discovery
improve
detection
strategies.
International Journal of Environmental Research and Public Health,
Год журнала:
2025,
Номер
22(4), С. 624 - 624
Опубликована: Апрель 16, 2025
Periodontal
disease
is
a
prevalent
chronic
inflammatory
condition
that
impacts
over
billion
people
worldwide,
leading
to
substantial
tooth
loss,
reduced
quality
of
life,
and
heightened
systemic
health
risks.
This
narrative
review
synthesizes
current
evidence
regarding
the
global
burden
periodontal
disease,
its
established
associations
with
conditions
including
cardiovascular
diabetes,
adverse
pregnancy
outcomes,
respiratory
infections,
neurodegenerative
disorders,
significant
socioeconomic
implications.
The
focused
on
following
research
question:
What
how
do
implications
necessitate
integrated
public
strategies?
A
structured
search
PubMed,
Scopus,
WHO
databases
from
2000
2024
was
conducted
identify
relevant
literature
using
key
terms,
“periodontal
disease”,
“global
burden”,
“systemic
inflammation”,
“public
strategies”.
Out
312
initially
identified
articles,
175
satisfied
inclusion
criteria
for
final
synthesis.
findings
underscore
significance
as
modifiable
risk
factor
various
noncommunicable
diseases,
influence
healthcare
disparities
progression,
critical
necessity
strategies
mitigate
consequences.
concludes
coordinated
policy
reform,
system
integration,
enhanced
efforts
are
crucial
mitigating
advancing
equity.
Dentistry Journal,
Год журнала:
2025,
Номер
13(4), С. 140 - 140
Опубликована: Март 25, 2025
Background:
Peri-implantitis,
the
most
prevalent
cause
of
implant
failure,
is
a
multifaceted
issue
that
influenced
by
various
factors
promote
biofilm
formation
around
implant.
Although
innovative
methods
for
microbiological
decontamination
dental
implants
exist,
universally
accepted
standard
protocol
has
not
yet
been
established.
However,
potential
device
generates
an
electric
current
(Ximplant®)
in
reducing
survival
microorganisms
within
promising
development.
Methods:
In
this
vitro
study,
five
implants,
contaminated
using
microbial
culture
from
sample
saliva
patient
suffering
peri-implantitis,
were
decontaminated
Ximplant®
peri-implantitis
protocol.
The
experimental
conditions
included
simulated
peri-implant
site
and
subsequent
fluorescent
assessment
Live/Dead
population.
Results:
qualitative
quantitative
image
analyses
showed
predominant
dead
light
signal
on
treated
sample,
demonstrating
efficacy
applying
electrostatic
field
to
surface
viability
implants.
Conclusions:
These
findings
could
inspire
new
era
treatment.
Periodontology 2000,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 25, 2024
The
study
aims
were
(1)
to
explore
whether
"periodontal
treatment"
consisting
of
surgical
therapy
(flap,
resective,
or
regenerative)
scaling
and
root
planing
treatment
with
long-term
periodontal
maintenance
treatment,
is
cost-effective
in
terms
preventing
periodontitis-attributable
tooth
extraction
replacement
by
implant-supported
crowns
("extraction/replacement");
(2)
assess
the
effect
cigarette
smoking
on
this
cost-effectiveness.
Data
for
observational
retrospective
collected
from
dental
charts
patients
who
had
received
at
least
annual
follow-up
visits
>10
years
analyzed
linear
regression
generalized
estimating
equations
models.
Among
399
adults
(199
males,
200
females),
those
mean
cost
experienced
greatest
costs
extraction/replacement,
indicating
general
Cigarette
adversely
impacted
cost-effectiveness,
current
heavy
smokers
experiencing
no
Former
Grade
C
periodontitis
benefitted
most,
whereas
did
not
influence
cost-effectiveness
B
periodontitis.
Assessed
"extraction/replacement,"
was
cost-effective,
which
decreased
a
dose-response
manner
former
intensity.
should
be
factored
into
planning
analyses
treatment.
Smoking
cessation
encouraged.
