Periodontitis and Its Role in Oral Cancer Susceptibility: A Case-Control Study DOI Creative Commons

Sujatha S. Reddy,

N. Rakesh,

Radha Prashanth

и другие.

Indian Journal of Medical and Paediatric Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Abstract Introduction Oral cancer and periodontitis are complex, multifactorial diseases, influenced by common risk factors such as genetic predisposition, lifestyle choices, oral health practices. While certain studies indicate a positive correlation between cancer, the precise mechanisms causation remain unclear. Objective This study aims to determine if individuals with have heightened of developing compared those healthy periodontal conditions. Materials Methods One hundred twenty-six participants, 63 without were enrolled. A structured questionnaire was developed gather data on demographics, socioeconomic status, factors, dietary habits, condition, hygiene practices, complete status. Statistical analysis used chi-squared Mann–Whitney U tests logistic regression understand potential influences development. Results Notable associations identified occurrence specific behaviors, including gender, age, education level, tobacco alcohol usage. Average Silness Loe plaque index values, probing pocket depth, clinical attachment loss values significantly higher in cases than controls. Patients exhibited incidence (63.9%) (32.4%). substantial majority patients (72.9%) stage 4 periodontitis, contrasting controls (30.6%). Conclusion Periodontitis emerges significant individual factor influencing Rigorous monitoring is recommended for compromised health, particularly severe concurrent factors. Prioritizing preservation high-risk holds promise mitigating cancer–associated risks.

Язык: Английский

Periodontal pathogens and cancer development DOI Creative Commons
Yuxi Zhou, Joerg Meyle, Sabine Groeger

и другие.

Periodontology 2000, Год журнала: 2024, Номер 96(1), С. 112 - 149

Опубликована: Июль 4, 2024

Abstract Increasing evidence suggests a significant association between periodontal disease and the occurrence of various cancers. The carcinogenic potential several pathogens has been substantiated in vitro vivo. This review provides comprehensive overview diverse mechanisms employed by different development cancer. These induce chronic inflammation, inhibit host's immune system, activate cell invasion proliferation, possess anti‐apoptotic activity, produce substances. Elucidating these might provide new insights for developing novel approaches tumor prevention, therapeutic purposes, survival improvement.

Язык: Английский

Процитировано

9
Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review DOI Creative Commons

Yaman Sulaiman,

Ingrida Marija Pacauskienė,

Renata Šadzevičienė

и другие.

Medicina, Год журнала: 2024, Номер 60(9), С. 1416 - 1416

Опубликована: Авг. 29, 2024

Periodontitis can disrupt oral and gut microbiota, leading to dysbiosis that affects overall systemic health. Besides the spread of periodontal pathogens by hematogenous route, they also be translocated into gastrointestinal tract, possibly intervening in neoplastic process tract. This manuscript reviews relationship between microbiota due periodontitis, discussing health implications potential links cancer. article highlights significance effect gut, emphasizing importance maintaining prevent diseases. Lastly, it will go through therapeutic innovations such as probiotics analysis tools for disease detection. These findings mark integration management clinical practice lower risk improve patient outcomes.

Язык: Английский

Процитировано

7
A Multirisk-Rescued Biomimetic Nanozyme Against Periodontitis Via Inflammation Targeting and Microenvironment Reprogramming DOI
Lin Li, Rui‐Xin Wu, Jia Wang

и другие.

Опубликована: Янв. 1, 2025

Periodontitis is an intractable chronic inflammatory disease characterized by excessive proinflammatory factors production and reactive oxygen species (ROS) accumulation. Nanodrugs have made significant contributions in the biomedical field but fall short as periodontitis therapeutics because of their singular effects, low retention rates, poor specificity, insufficient biocompatibility. Herein, we report a functionalized periodontal ligament stem cell (PDLSC) membrane-camouflaged MnO2 nanoplatform (MnO2@hPM) to target reprogram microenvironment periodontitis. PDLSC-affinity biological molecules hypoxia-educated proteins on membrane coating endow MnO2@hPM with capacities actively PDLSCs under environment, concurrently neutralize various factors, scavenge overburdened ROS. The synergistic effects inflammation inhibition ROS elimination mitigate mitochondrial dysfunction, improve metabolic disturbance, restore osteogenic potential inflammation-impaired PDLSCs. In vivo, effectively accumulates at sites, significantly ameliorates inflammation, alleviates bone loss artificial periodontitis, showing optimized therapeutic performance for tissue reconstruction. This multirisk-rescuing biomimetic nanozyme good biocompatibility exhibits inflammation-targeting ability benefits against highlighting its advanced therapy other diseases.

Язык: Английский

Процитировано

0
A multirisk-rescued biomimetic nanozyme against periodontitis via inflammation targeting and microenvironment reprogramming DOI
Lin Li, Rui‐Xin Wu, Jia Wang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160119 - 160119

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Porphyromonas gingivalis -OMVs promote the epithelial-mesenchymal transition of oral squamous cell carcinoma by inhibiting ferroptosis through the NF-κB pathway DOI Creative Commons

Xinyue Liao,

Hang Si,

Yongxian Lai

и другие.

Journal of Oral Microbiology, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 3, 2025

Recent studies reported the role of Porphyromonas gingivalis (P. g) in promoting oral squamous cell carcinoma (OSCC) progression. However, molecular mechanism remains unclear. P. g-OMVs were isolated using ultracentrifugation method and characterized by transmission electron microscopy (TEM) nanoparticle tracking analysis (NTA). CCK-8, migration, invasion, Quantitative real-time Polymerase Chain Reaction (qRT-PCR) immunocytochemistry assays performed to evaluate effect on tumor cells' proliferation, epithelial-mesenchymal transition (EMT), ferroptosis vitro. Western blot was study phosphorylation transcription factor nuclear kappa B (NF-κB). In vivo, growth OSCC evaluated a xenograft model, followed hematoxylin eosin immunohistochemistry staining. TEM NTA demonstrated that have vesicular structure with particle size around 118 nm. Compared control group, significantly enhance invasion cells. addition, promote EMT cells, which can be attenuated activator erastin. Moreover, inhibit feroptosis activating NF-κB signaling. OSCC. Inhibition could significnatly reduce OSCC, further rescued inhibitor Ferrostain-1. progression modulating ferroptosis-related through

Язык: Английский

Процитировано

0
Periodontal diseases, potential mediators and development of liver fat content: a community-based large cohort DOI Creative Commons

Bofu Liu,

Yu Jia,

Zhuo-Jun Gu

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 9, 2025

A high level of liver fat content (LFC) is a key indicator steatotic disease (SLD), reflecting its pathological essence. Periodontal (PD) recognized as chronic inflammatory condition and cause widespread adverse health impact. This study aims to investigate the relationship between PD LFC development. In UK Biobank, were gathered through digital questionnaire, including gum pain, bleed, or teeth loose. was measured by Fatty Liver Index (>60 indicates SLD) in cross-sectional analysis magnetic resonance imaging (quantified Proton Density Fat Fraction, PDFF) longitudinal analysis. Multivariable logistic linear regression models conducted association LFC. analysis, 164,150 (37.4%) individuals diagnosed with SLD, showed significant SLD (odds ratio: 1.104, 95% CI: 1.075-1.132). prospective total 39,656 participants median follow-up 10.3 years included. an arithmetic mean difference 0.091 PDFF (95% 0.047-0.139), males exhibiting stronger than females (P for interaction <0.05). Significant mediating effects observed body mass index (19.58%), C-reactive protein (11.61%), blood glucose (6.70%), healthy diet score (5.99%) all <0.001). There pronounced correlation LFC, predominantly driving this link. may be partially mediated fat, inflammation, dietary habit, insulin resistance.

Язык: Английский

Процитировано

0
Severe periodontitis and congenital cytomegalovirus: Cleft lip and cleft palate DOI Creative Commons
Jørgen Slots,

Vanessa Slots

Periodontology 2000, Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

Abstract Severe periodontitis lesions can harbor several hundred‐thousand copies of active cytomegalovirus, and this paper proposes that cytomegalovirus in maternal infect the fetus. Cleft lips palates may be oral examples congenital infection. Anti‐cytomegalovirus periodontal treatment is indicated for high‐risk women who exhibit severe weakened immune system are contemplating pregnancy or first trimester pregnancy.

Язык: Английский

Процитировано

0
Oral Microbial Changes in Oral Squamous Cell Carcinoma: Focus on Treponema denticola, Lactobacillus casei, and Candida albicans DOI Creative Commons
Yeon‐Hee Lee, Junho Jung, Ji‐Youn Hong

и другие.

Medicina, Год журнала: 2024, Номер 60(11), С. 1753 - 1753

Опубликована: Окт. 25, 2024

In this study, we aimed to explore the oral bacteria and fungi that can help discern squamous cell carcinoma (OSCC) investigate correlations between multiple key pathogens.

Язык: Английский

Процитировано

0
Periodontitis and Its Role in Oral Cancer Susceptibility: A Case-Control Study DOI Creative Commons

Sujatha S. Reddy,

N. Rakesh,

Radha Prashanth

и другие.

Indian Journal of Medical and Paediatric Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Abstract Introduction Oral cancer and periodontitis are complex, multifactorial diseases, influenced by common risk factors such as genetic predisposition, lifestyle choices, oral health practices. While certain studies indicate a positive correlation between cancer, the precise mechanisms causation remain unclear. Objective This study aims to determine if individuals with have heightened of developing compared those healthy periodontal conditions. Materials Methods One hundred twenty-six participants, 63 without were enrolled. A structured questionnaire was developed gather data on demographics, socioeconomic status, factors, dietary habits, condition, hygiene practices, complete status. Statistical analysis used chi-squared Mann–Whitney U tests logistic regression understand potential influences development. Results Notable associations identified occurrence specific behaviors, including gender, age, education level, tobacco alcohol usage. Average Silness Loe plaque index values, probing pocket depth, clinical attachment loss values significantly higher in cases than controls. Patients exhibited incidence (63.9%) (32.4%). substantial majority patients (72.9%) stage 4 periodontitis, contrasting controls (30.6%). Conclusion Periodontitis emerges significant individual factor influencing Rigorous monitoring is recommended for compromised health, particularly severe concurrent factors. Prioritizing preservation high-risk holds promise mitigating cancer–associated risks.

Язык: Английский

Процитировано

0