Periodontal disease: A systemic condition

Periodontology 2000, Год журнала: 2024, Номер 96(1), С. 7 - 19

Опубликована: Окт. 1, 2024

Abstract For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in oral cavity. Initially, associations with multitude noncommunicable diseases were each studied separately, and relationships shown. The morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory have demonstrated. As most studies cross‐sectional nature, questions about causality cannot univocally answered. And an independent risk factor for one systemic disease, becomes even more difficult assess since recently also associated multimorbidity. Periodontitis many share environmental, lifestyle genetic factors, immunopathology. Moreover, suffering from common may increase susceptibility another chronic disease; effects condition various factors disease. overarching effect any is it causing pro‐inflammatory state individual; this shown periodontitis. prothrombotic elevated immunological activity such, when we consider can affect progression other importantly, vice versa. this, not surprising that variety diseases. medical definition includes different organs systems. Thus, aim opinion paper propose should its own right affects individual's wellbeing. dental profession researchers alike, adapt paradigm shift, advancing out isolated anatomical location into total being some conditions comorbid and, versa, comorbidities initiation

Язык: Английский

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Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence

Metabolites, Год журнала: 2025, Номер 15(1), С. 35 - 35

Опубликована: Янв. 9, 2025

Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by dysbiotic oral microbiota and negatively correlated with several systemic diseases. The low-chronic burden gingival inflammation not only exacerbates periodontitis but also predisposes individuals to spectrum age-related conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic dysfunction, especially related ageing. In this regard, over local periodontal treatment, lifestyle modifications adjunctive therapies may offer synergistic benefits in ameliorating both health ageing populations. Elucidating intricate connections between senescence important for understanding health's implications Effective management strategies targeting senescent pathways novel avenues promoting healthy preventing morbidities. This review will analyze current literature about interplay periodontitis, dysbiosis, processes senescence, shedding light on their collective impact modulation accelerated Lastly, therapeutic dysbiosis mitigate its associated morbidities be discussed.

Язык: Английский

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Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 25 - 25

Опубликована: Янв. 14, 2025

Oral diseases such as dental caries, periodontitis, and oral cancer are prevalent present significant challenges to global public health. Although these typically treated through procedures like preparation resin filling, scaling root planning, or surgical excision, interventions often not entirely effective, postoperative drug therapy is usually required. Traditional treatments, however, limited by factors poor penetration, side effects, the development of resistance. As a result, there growing need for novel delivery systems that can enhance therapeutic efficacy, reduce improve treatment outcomes. In recent years, drug-loaded vesicles, liposomes, polymersomes, extracellular vesicles (EVs), have emerged promising platforms due their high encapsulation efficiency, controlled release properties, excellent biocompatibility. This review provides an in-depth examination characteristics, advantages, limitations in context disease treatment. It further explores reasons advantages discusses specific applications, prospects, strategies optimizing vesicle-based improved clinical

Язык: Английский

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Advanced biomaterials for targeting mature biofilms in periodontitis therapy

Bioactive Materials, Год журнала: 2025, Номер 48, С. 474 - 492

Опубликована: Фев. 27, 2025

Язык: Английский

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Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 1875 - 1886

Опубликована: Фев. 1, 2025

Background and Objective: Periodontitis is a chronic inflammatory disease caused by dental plaque accumulation, leading to damage of periodontal tissues potential tooth loss. Understanding the mechanisms periodontitis, particularly role hypoxia in inflammation, critical for identifying novel therapeutic strategies. This study investigated effects prolyl hydroxylase (PHD) inhibitor DMOG on pro-inflammatory cytokine expression human ligament stem cells (hPDLSCs) examined involvement HIF-1α/YAP signaling path ay modulating inflammation. Materials Methods: hPDLSCs were cultured treated with lipopolysaccharide (LPS) induce followed treatment. Cell proliferation was assessed using CCK-8 assay, while ELISA RT-qPCR evaluated levels HIF-1α, IL-1β, TNF-α, YAP. YAP knocked down siRNA transfection examine its cytokines. Results: significantly increased HIF-1α reducing IL-1β TNF-α LPS-treated hPDLSCs. 0.1 mmol/L inhibited cell after 72 hours (P < 0.001). results showed that concentrations LPS + group higher than 0.01), reduced 0.01). confirmed these trends, showing mRNA 0.0001). knockdown via reversed effects, increasing 0.01) 0.05). Conclusion: demonstrated reduces stabilizing activating pathway. These findings provide mechanistic basis targeting axis control inflammation support PHD inhibitors as agents periodontitis. Keywords: YAP, DMOG,

Язык: Английский

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IMPACTOS IMUNOLÓGICOS DA DOENÇA PERIODONTAL

Revista Contemporânea, Год журнала: 2025, Номер 5(2), С. e7432 - e7432

Опубликована: Фев. 10, 2025

Introdução: A Doença Periodontal é uma das condições inflamatórias crônicas mais prevalentes, impactando tanto a saúde oral quanto sistêmica. Classificada em gengivite e periodontite, DP resulta de interação complexa entre fatores bacterianos resposta imunológica do hospedeiro. Objetivo: apresentar, através revisão narrativa literatura, os impactos imunológicos da doença periodontal. Metodologia: Foi realizada literatura bases dados como PubMed, Scielo Google Acadêmico. Foram incluídos artigos publicados 2015 2025, português inglês, com acesso integral online. Assim como, foram excluídos livros, capítulos livro, teses, dissertações, monografias, resumos anais cartas para o autor. Após triagem, 14 estudos selecionados análise. Resultados: caracterizada pela presença biofilme bacteriano, que provoca inflamatória nos tecidos periodontais. sistema imunológico fundamental desenvolvimento doença, ativação células imunidade inata, neutrófilos macrófagos, adaptativa, linfócitos T B. O desequilíbrio mediadores inflamatórios osteoclastos na destruição óssea perda dentária. Conclusão: desempenha um papel central progressão Periodontal, sendo influenciada por ambientais sociodemográficos. Compreender mecanismos essencial estratégias terapêuticas minimizem sistêmicos periodontais doença.

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10‐year follow‐up of adolescent leukemia diagnosed through gingiva: A case report

Clinical Advances in Periodontics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Background Systemic diseases often present initial signs through oral manifestations, making early recognition essential for accurate diagnosis and effective treatment planning. Patients with acute lymphoblastic leukemia (ALL) commonly experience gingival issues. This case report discusses the outcomes of a 12‐year‐old female patient who presented swelling pain was subsequently diagnosed ALL. Methods The underwent chemotherapy basic periodontal supragingival scaling. Comprehensive clinical assessments, photographs, imaging data were recorded at visit, follow‐ups 8 years 10 later. Results A routine blood test bone marrow aspiration confirmed B‐cell (B‐cell ALL). After 1 year rituximab, recovered discharged. An 8‐year follow‐up revealed significant attachment gain healthy status, complete recovery observed 10‐year follow‐up. Conclusions Adolescents presenting swollen bleeding gums should be evaluated potential leukemia. Dentists, especially periodontists, aware manifestations ALL coordinate medical professionals to establish comprehensive, long‐term plan. Periodontal health in adolescents can improve significantly remission appropriate therapy. Key points Oral as indicators: In (ALL), systemic symptoms may minimal or absent. Early changes, such bleeding, is crucial timely diagnosis. Long‐term recovery: indicates that following therapy, although longer recommended assess stability recovery. Plain Language Summary It challenging recognize adolescents, which critical Acute disease system manifests itself gingiva. describes adolescent manifestation process. chemotherapy, cured. 8th year, red, painful gingiva relieved, no resorption alveolar observed, condition fully two after treatment. emphasizes importance dentists being vigilant cavity role maintenance.

Язык: Английский

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Insights into associations between oral and general health outcomes of nursing home residents based on interRAI data: a cross-sectional study (Preprint)

Опубликована: Фев. 7, 2025

Oral health of nursing home residents is generally poor, largely due to age-related conditions that increase their vulnerability and make them more dependent on others for oral care. Poor can significantly impact general well-being, highlighting the important role caregivers in preventing, detecting, addressing residents’ problems time. The interRAI Suite instruments, widely used comprehensive assessments, offers opportunity non-dental assess as part well-being facilitates integration care planning. Based data, this study explored associations between outcomes Flanders (Belgium) Netherlands. This cross-sectional included baseline assessments 2362 Flemish Dutch aged 65 years older, collected by (e.g., nurses, nurse aids, etc.) October 2020 February 2024. Validated outcome scales Activities Daily Living Hierarchy scale, Cognitive Performance Scale, Depression Rating Scale), such diabetes, low weight (BMI ≤19), well family support participation social activities, instrument, provided information well-being. was defined according nine items optimized section inclusion OHS-interRAI. Adjusted logistic regression models were explore outcomes. interconnected, with one structure impacting others. When controlling confounding variables, dependency personal hygiene associated poor (OR 1.7, 95% CI 1.1-2.4), chewing difficulties 2.2, 1.3-3.5), compromised teeth 1.1-2.5), need dental referral 1.8, 1.4-2.3). Natural dentition gender had a significant status. Low function 2.0, 1.1-3.6) dry mouth 1.0-3.2), both discomfort or pain respectively 6.8, 3.3-14.0 3.5, 1.8-6.9). Family identified facilitator mitigating problems. including OHS-interRAI, valuable tool monitoring residents' identifying areas requiring additional support. results demonstrated importance prioritizing an integral component Recognizing interconnection other conditions, indicators guide healthcare professionals incorporating preventive supportive practices into daily routines, contributing improved resident

Язык: Английский

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Temporal Transcriptomic Analysis of Periodontal Disease Progression and Its Molecular Links to Systemic Diseases

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1998 - 1998

Опубликована: Фев. 25, 2025

Periodontal disease, a prevalent oral inflammatory condition, is implicated in exacerbating systemic diseases. However, the molecular mechanisms underlying this association remain unclear. In study, we performed RNA sequencing of gingival tissue samples collected from mouse model periodontal disease at multiple time points to investigate dynamic transcriptomic changes during progression. Our analysis revealed distinct temporal gene expression patterns associated with key and immune response pathways. These findings suggest stepwise progression process, potentially contributing inflammation through shared signaling networks. We further identified specific genes pathways that may mediate bidirectional relationship between conditions such as cardiovascular diabetes. By elucidating dynamics study provides insights into pathogenesis its implications. It identifies potential biomarkers therapeutic targets for local management.

Язык: Английский

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Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II

Diagnostics, Год журнала: 2025, Номер 15(5), С. 609 - 609

Опубликована: Март 3, 2025

Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates severity conditions. Matrix metalloproteinases (MMPs) are known to degrade ligament attachment bone matrix proteins. Increased expression CD147 associated with increased synthesis several MMPs, being modulator MMP expression, including that MMP-14. The purpose this study was quantify compare expressions MMP-14 in gingival tissues patients without type 2 diabetes mellitus. Material Methods: In histological study, we included 33 subjects disease: 16 DM (test group) 17 systemically healthy (control group). Tissue fragments were processed using an immunohistochemistry technique determine immunoreactivity (IR) intensity CD147. Results: group periodontitis, 56.2% showed weak positive (+), while 43.8% had intensely (+++) Statistically significant differences between test control groups (p = 0.004, p 0.883, 0.002) found membranous IR moderate (++) CD 147, (+++). 0.001, 0.002, 0.003) Conclusions: significantly higher 147 demonstrates role these biomarkers pathology patients. It can be assumed could further investigated as potential predictive biomarkers.

Язык: Английский

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