Brazilian Oral Research, Год журнала: 2024, Номер 38(suppl 1)
Опубликована: Янв. 1, 2024
Язык: Английский
IgMin Research, Год журнала: 2025, Номер 3(2), С. 097 - 103
Опубликована: Фев. 25, 2025
Numerous studies indicate that periodontal diseases affect a large portion of the adult population, and gum disease is primary cause losing teeth in future. Periodontal are global health concern. most common serious oral illnesses, affecting not only gums but also tissue bone support teeth. It begins as gingivitis, slight swelling resulting from buildup bacterial plaque. If treated appropriately, it may advance to periodontitis, where inflammation infection spread deeper, causing damage bone. The scientific data deals with stress vast; covers different theories influence stress, consequences on body brain, other contributors stress. contains heterogeneous findings about stress's causes, nature, subsequent effects. Aim: Since prevalent problem modern life, present work aims estimate association between diseases, investigating central relations highlighted data. Methods: search comprised electronic databases: MEDLINE (PubMed), Google Scholar, open access journals published by Elsevier. keywords for were "stress," "periodontal diseases," "cortisol," "saliva" combinations. considered works 2014 until December 2024. procedure shown PRISMA flowchart. Conclusion: This review highlights links physiological hormone cortisol, emphasizing importance considering risk factor health. Understanding these relationships can help clarify discrepancies treatment effectiveness inform future healthcare practices.
Язык: Английский
Процитировано
0
Redox Report, Год журнала: 2025, Номер 30(1)
Опубликована: Март 9, 2025
Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates connection between HHcy periodontitis; however, the underlying processes remain unknown. Herein, we explored mechanisms by which exacerbates osteoclast formation. In an animal model of periodontitis treated with HHcy, attachment loss was aggravated, both systemic gingival tended increase; additionally, antioxidant-related proteins were suppressed expressed at low levels, whereas oxidative damage-related protein expression increased. RAW264.7 cells LPS or + Hcy, Hcy group presented reactive oxygen species (ROS) fluorescence intensity, Nrf2/HO-1 signalling pathway suppression associated inflammatory cytokine (TNF-α) expression. monocyte osteoclasts Rankl suppression, increase osteoclast-related (NFATc-1 CTSK), more pronounced osteoclastic phenotype. Therefore, may exacerbate severity generation promoting ROS production inhibiting pathway.
Язык: Английский
Процитировано
0
Journal of Periodontal Research, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
ABSTRACT Aim Circulating platelets are essential in hemostasis, thrombosis, and immune responses. Modifications platelet function may impact immunological reactions to dental biofilm cardiovascular health. Understanding changes status activity patients with periodontitis is still a subject of investigation. This study aimed synthesize evidence from observational studies that investigated without periodontitis. Methods MEDLINE‐PubMed, EMBASE, Cochrane‐CENTRAL Library databases were searched up November 2024. Primary outcomes included count (PC) mean volume (MPV). Secondary encompassed any other biomarker relevant activity. Methodological quality was evaluated using the Newcastle‐Ottawa scale, heterogeneity analyzed. Descriptive analysis meta‐analysis, incorporating trial sequential PC MPV, conducted. The body graded by utilizing Grading Recommendations Assessment, Development, Evaluation (GRADE). Results 3621 unique records identified, resulting 23 eligible 22 variables evaluating status. Fourteen exhibited low risk bias, 9 moderate bias. significantly higher compared individuals (Mean Difference (MD) = 23.55 ×10 /L, 95% CI [7.68; 39.43]). There no statistically significant difference between groups for MPV (MD 0.16 fL, [−0.49; 0.82]). Trial indicated conclusive meta‐analysis highlighted need additional data on future trials. Conclusions certainty slightly it two groups. not robust claim clear activation biomarkers Registration: International Prospective Register Systematic Reviews (PROSPERO) number: CRD42023439051
Язык: Английский
Процитировано
0
Diagnostics, Год журнала: 2025, Номер 15(7), С. 928 - 928
Опубликована: Апрель 4, 2025
Background/Objectives: Periodontitis is an inflammatory disease associated with many systemic disorders such as diabetes and cardiovascular disease. The aim was to evaluate the usefulness of CDC/AAP EFP/AAP criteria detect subclinical atherosclerosis in subjects severe periodontal Methods: This a cross-sectional study. Atheroma plaque evaluated by high-resolution carotid femoral ultrasonography. A dental examination protocol implemented trained periodontist. full-mouth clinical carried out at six sites automated computerized Florida Probe Periodontal Probing. defined criteria. Results: In total, 98 patients were included (60.2% women), which 50% had diabetes. Subjects showed high prevalence cases Both useful presence atheroma only However, higher correlation plaques than (r = 0.522 vs. r 0.369, p < 0.001). Conclusions: are tool identify These results show potential role oral healthcare team office for identification risk developing
Язык: Английский
Процитировано
0
International Dental Journal, Год журнала: 2025, Номер 75(3), С. 1781 - 1797
Опубликована: Апрель 15, 2025
Язык: Английский
Процитировано
0
Infection, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(5), С. 1134 - 1134
Опубликована: Май 7, 2025
Background/Objectives: Periodontal disease involves chronic immunoinflammatory processes and microbial dysbiosis, making phytochemicals with anti-inflammatory properties potential therapeutic agents. This study aimed to assess the modulatory effects of yellow passion fruit bagasse extract (PFBE) on periodontal cells under condition. Methods: A human ligament (PDL) cell line was exposed F. nucleatum ATCC 25586 simulate a environment in vitro presence absence PFBE containing three different concentrations (0.25, 0.50, 1.00 µg/mL) piceatannol. Pro-inflammatory markers (TNF-α, IL-8, CCL2), antioxidant enzyme SOD2, protease marker MMP-1 were analyzed by real-time PCR. Protein levels assessed via ELISA NF-κB nuclear translocation immunofluorescence. Cell viability investigated using live/dead alamarBlue assays, wound healing evaluated an automated scratch assay. Results: PDL significantly increased gene protein expression all inflammatory markers. The stimulatory reduced when simultaneously PFBE. triggered while abrogated nucleatum-stimulated at 60 min. Viability assays demonstrated that neither nor toxic or affected viability. In closure improved addition nucleatum. Conclusions: exhibited anti-proteolytic improving healing, suggesting role prevention treatment.
Язык: Английский
Процитировано
0
Frontiers in Dental Medicine, Год журнала: 2025, Номер 6
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0
Journal of Interferon & Cytokine Research, Год журнала: 2025, Номер unknown
Опубликована: Май 20, 2025
The association between local oral inflammation and cardiovascular risk has been extensively studied, with results indicating a bidirectional relationship. aim of the present study was to investigate associations blood cells large number salivary cytokines, chemokines, growth factors. consisted 165 individuals who were referred Oral Maxillofacial Surgery clinic at Falun County hospital, Sweden, for surgical removal impacted lower third molar. subjects did not have any known inflammatory disorders. Complete cell counts analyzed using routine laboratory Hospital, Falun, Sweden. Proteomic analysis 92 inflammation-related protein biomarkers in saliva performed multiplex proximity extension assay. After adjustment multiplicity testing false discovery rate approach, there remained significant several factors white (n = 19), neutrophil 18), erythrocyte 13), hemoglobin concentrations 20), volume fractions 22), platelet 12). There are cytokines cavity parameters relationship systemic activity.
Язык: Английский
Процитировано
0
Periodontology 2000, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Abstract The primary objective is to critically analyze approaches local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential treatments contrast their actual clinical effectiveness. Historically, therapeutic approach periodontitis has concentrated on intervention within pockets. Local drug delivery systems show targeting infections with high concentrations while minimizing side effects. This could potentially help overcome challenges posed by microbial biofilms. However, evidence suggests that not a disease affecting only confined areas dentition. Currently, presence multiple deep pockets, less cost‐effective than antibiotics due costs products extensive professional chair time required application. Isolated pockets otherwise stable dentitions are often caused problems cannot be resolved antimicrobial agents. Finally, recurrent biofilm formation residual during maintenance phase can addressed through suitable physical rather chemical procedures.
Язык: Английский
Процитировано
0