Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications—A Comprehensive Review
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(3)
Опубликована: Март 1, 2025
ABSTRACT
Phytochemicals
are
bioactive
compounds
found
in
plants
that
play
a
key
role
promoting
health
and
preventing
diseases.
Present
fruits,
vegetables,
grains,
seed
oils,
these
considered
safe
for
consumption
due
to
the
co‐evolution
adaptation
between
mammals
plants.
Due
their
wide‐ranging
biological
effects,
they
have
attracted
considerable
research
interest.
This
comprehensive
review
explores
mechanisms
of
action,
benefits,
applications
dietary
phytochemicals,
with
particular
focus
on
groups
such
as
polyphenols,
flavonoids,
carotenoids.
Research
shows
phytochemicals
interact
nuclear
membrane
receptors,
influence
metabolic
pathways,
affect
epigenetic
modifications.
Our
highlights
broad
range
activities
compounds,
including
antioxidant,
antibacterial,
anti‐inflammatory,
anti‐diabetic,
anticancer
all
which
contribute
health‐promoting
properties.
Clinical
evidence
supports
prevention
management
diseases
cardiovascular
disorders,
conditions,
cancer,
diets
rich
being
linked
lower
risk
disease.
also
at
cutting
edge
food
preservation,
supplements,
emerging
medical
treatments.
Additionally,
we
identified
advancements
extraction
identification
techniques,
particularly
metabolomics,
further
enhance
areas.
Despite
promising
challenges
bioavailability,
regulatory
barriers,
need
robust
clinical
trials
persist.
However,
innovative
delivery
systems
like
nanoparticles,
liposomes,
encapsulation
offer
potential
solutions
bioavailability
by
improving
absorption
stability.
The
concludes
emphasizing
personalized
nutrition
combination
therapies
benefits
while
stressing
methods,
trials,
bioavailability.
Язык: Английский
The synergistic role of β-glucan and Bacillus Coagulans on the growth, blood hematological and biochemical indices, intestinal structure, redox status, immune response, and regulation of specific genes in Sparus aurata L.
Aquaculture,
Год журнала:
2025,
Номер
unknown, С. 742316 - 742316
Опубликована: Фев. 1, 2025
Язык: Английский
Effects of artichoke (Cynara scolymus) polyphenolic extract on growth, antioxidants and some immune parameters in common carp (Cyprinus carpio)
BMC Veterinary Research,
Год журнала:
2025,
Номер
21(1)
Опубликована: Март 17, 2025
In
this
research,
Cyprinus
carpio
juveniles
were
fed
with
experimental
diets
containing
different
levels
of
artichoke
polyphenolic
leaf
extract
(ALE)
0
(Control),
0.5,
1,
and
2
g/kg
over
eight
weeks.
After
weeks,
haemato-immunological
parameters,
growth
performance,
immune
parameters
antioxidant
defense
measured.
The
administration
varying
ALE
had
no
significant
effects
on
compared
to
the
control
group.
However,
haematological
significantly
elevated
Immune
such
as
serum
lysozyme,
mucus
total
immunoglobulin,
well
alternative
complement
activity
bactericidal
ALE-treated
carps,
showed
a
notable
increase
in
comparison
CTRL
Also,
agglutination
titer
carps
higher
than
Feeding
(0.5,
g/kg)
enhanced
activities
enzymes,
including
superoxide
dismutase
all
groups,
catalase
0.5
glutathione
peroxidase
1
results
study
demonstrate
that
dietary
supplementation
at
0.5–2
positively
influences
factors
carpio,
most
pronounced
observed
g/kg.
These
findings
suggest
extract,
particularly
dosages,
has
potential
an
effective
feed
additive
enhance
immunity
capacity
carp
farming.
Язык: Английский
Investigating a novel β-glucan source to enhance disease resistance in Pacific white shrimp (Penaeus vannamei)
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 2, 2025
β-glucans
supplements
are
known
for
enhancing
disease
resistance
and
performance
in
shrimp
aquaculture,
but
their
effectiveness
depends
on
source
structure.
This
study
investigated
a
novel
β-glucan
derived
from
the
insect
fungus
Ophiocordyceps
dipterigena
BCC
2073
as
potential
feed
additive
Pacific
white
(Penaeus
vannamei).
To
determine
its
feasibility,
juvenile
shrimps
were
fed
diets
supplemented
with
0%,
0.1%,
0.4%
oligosaccharide
30
days
prior
to
evaluation.
The
groups
supplementation
showed
improved
immune
levels
significantly
higher
survival
rates
(p-value
<
0.05)
when
exposed
pathogen
Vibrio
harveyi.
Transcriptome,
microbiome,
metabolome
employed
understand
mechanisms
of
supplement.
altered
expression
host
genes
linked
immunity,
inflammation,
intestinal
barrier
function.
Moreover,
spp.
Pseudoalteromonas
abundances
modulated
specific
clades
responding
differently
depending
concentration.
Metabolomic
analysis
revealed
immune-supporting
metabolites
such
hydroquinone
nicotinic
acid,
potentially
promoting
homeostasis,
consistent
observed
gene
profiles.
highlights
O.
improve
health.
Язык: Английский
Promising Probiotic Candidates for Sustainable Aquaculture: An Updated Review
Animals,
Год журнала:
2024,
Номер
14(24), С. 3644 - 3644
Опубликована: Дек. 17, 2024
With
the
intensification
of
aquaculture
to
meet
rising
demands
fish
and
shellfish,
disease
outbreaks
during
larval
adult
stages
are
a
major
challenge
faced
by
aqua
culturists.
As
prophylactic
use
vaccines
antibiotics
has
several
limitations,
research
is
now
focused
on
sustainable
alternatives
antibiotics,
e.g.,
medicinal
plants,
probiotics,
postbiotics,
prebiotics,
synbiotics,
as
promising
candidates
strengthen
immune
response
shellfish
control
outbreaks.
respect
numerous
studies
available
revealing
their
health-promoting
beneficial
impacts
in
aquaculture.
However,
most
focus
Bacillus
Lactobacillus
species.
Keeping
view
positive
effects
probiotic
lactic
acid
bacteria
aquaculture,
researchers
looking
for
other
that
can
be
used
Recently,
many
non-lactic
(non-LAB),
which
mainly
host-associated,
have
been
reported
reveal
The
main
non-LAB
genera
Bifidobacterium,
Clostridium,
Microbacterium,
Micrococcus,
Paenibacillus,
Acinetobacter,
Alcaligenes,
Enterobacter,
Phaeobacter
Pseudoalteromonas,
Pseudomonas,
Vibrio.
Despite
comparably,
there
limited
information
this
context.
This
review
focuses
only
strains
non-LAB,
mostly
isolated
from
host
digestive
tract
or
rearing
water,
discusses
will
provide
detailed
various
roadmap
future
new
probiotics
Язык: Английский