Persimmon (Diospyros kaki L.) leaves accelerates skin tissue regeneration in excisional wound model: possible molecular mechanisms
Journal of Molecular Histology,
Год журнала:
2025,
Номер
56(1)
Опубликована: Янв. 24, 2025
Язык: Английский
Prophylactic Effects of Rhamnetin Flavonoid on Indomethacin‐Induced Gastric Ulceration by Modulating HSP 70/Bax, SOD/MDA and TNF‐α/IL‐10
Clinical and Experimental Pharmacology and Physiology,
Год журнала:
2025,
Номер
52(4)
Опубликована: Фев. 19, 2025
ABSTRACT
Rhamnetin
is
a
naturally
occurring
flavonoid
compound
found
in
many
wild
plant
species
and
indigenous
fruits.
Despite
its
numerous
biological
potentials,
such
as
anti‐inflammatory,
antioxidant
antimicrobial
effects,
there
lack
of
literature
elucidating
gastroprotective
action
anticipating
molecular
mechanism.
Natural
products
can
be
good
alternative
to
overcome
the
side
effects
relapses
associated
with
anti‐ulcer
drugs.
This
study
aims
elucidate
rhamnetin's
acute
toxicity
using
indomethacin
ulceration
model.
Animals
were
arbitrarily
divided
into
five
groups:
negative
control
group
(A)
positive
(B),
both
treated
1%
carboxymethyl
cellulose;
reference
(C)
receiving
20
mg/kg
omeprazole;
low‐dose
(D)
high‐dose
(E)
rhamnetin
groups
30
60
mg/kg,
respectively.
After
1
h,
rats
Groups
B–E
subjected
indomethacin‐induced
ulceration.
Toxicity
evaluations
indicated
safety
at
doses
up
400
rats,
without
any
noticeable
physiological
alterations.
(30
mg/kg)
administered
orally
h
before
gastric
ulcer
ameliorated
stomach
lesions
lowered
index
area
by
73.81%
77.87%,
supplementation
histopathological
alterations
restored
barriers,
including
pH
mucin
secretion.
Moreover,
rhamnetin‐treated
exhibited
increased
anti‐apoptotic
heat
shock
protein
70
decreased
Bax
tissues.
These
findings
line
accumulated
MDA,
superoxide
dismutase,
catalase
prostaglandin
E2
levels,
reduced
serum
inflammatory
mediators
(TNF‐α
interleukin‐6)
elevated
interleukin‐10
cytokines.
The
outcomes
indicate
cicatrising
against
indomethacin‐mediated
ulceration,
possibly
due
modulatory
actions
on
oxidative
stress,
inflammation
apoptotic
pathways.
Язык: Английский
A bitter flavonoid gum from Dorema aucheri accelerate wound healing in rats: Involvement of Bax/HSP 70 and hydroxyprolin mechanisms
Skin Research and Technology,
Год журнала:
2024,
Номер
30(8)
Опубликована: Авг. 1, 2024
Abstract
Background
Dorema
aucheri
gum
(DAG)
is
a
bitter
flavonoid
widely
used
for
numerous
medicinal
purposes
including
wound
recovery.
The
present
work
investigates
the
acute
toxicity
and
wound‐healing
effects
of
DAG
in
excisional
skin
injury
rats.
Materials
methods
Sprague
Dawley
rats
(24)
were
clustered
into
four
groups,
each
rat
had
full‐thickness
dorsal
neck
(2.00
cm)
addressed
with
0.2
mL
following
treatments
15
days:
Group
A
(vehicle),
normal
saline;
B,
received
intrasite
gel;
C
D,
250
500
mg/kg
DAG,
respectively.
Results
results
revealed
absence
any
toxic
signs
who
oral
dosages
2
5
g/kg
DAG.
Wound
healing
was
significantly
accelerated
indicated
by
smaller
open
areas
higher
contraction
percentages
compared
to
vehicle
Histological
evaluation
fibroblast
formation,
collagen
deposition,
noticeably
lower
inflammatory
cell
infiltration
granulated
tissues
DAG‐addressed
treatment
caused
significant
modulation
immunohistochemical
proteins
(decreased
Bax
increased
HSP
70)
mediators
(reduced
TNF‐α,
IL‐6,
magnified
IL‐10),
which
varied
Moreover,
topical
led
upregulation
hydroxyproline
(HDX)
(collagen)
antioxidant
content.
At
same
time,
decreased
lipid
peroxidation
(MDA)
levels
healed
obtained
from
DAG‐treated
Conclusion
might
be
linked
modulatory
effect
its
phytochemicals
(polysaccharides,
flavonoids,
phenolic)
on
cellular
mechanisms,
justify
their
folkloric
use
provokes
further
investigation
as
therapeutic
drug
additives
contraction.
Язык: Английский
Anchusa officinalis accelerates wound healing via the improvement of transforming growth factor beta 1 expressions, antioxidant levels, and inhibition of TNF-α, IL-6
Cutaneous and Ocular Toxicology,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Март 26, 2025
Wound
healing
is
an
intricate,
complicated
process
that
needs
special
attention
because
of
its
related
complications
may
occur
if
not
treated
properly
or
therapeutic
insufficiency.
Common
bugloss
(Anchusa
officinalis
L.)
a
deep-rooted,
hairy
perennial
herb
used
in
folk
medicine
for
numerous
human
issues,
including
wound
recovery.
To
delineate
safety
and
potentials,
we
investigated
the
acute
toxicity
wound-healing
effects
Anchusa
L.
(APEAO)
aerial
part
extracts
on
excisional
neck
injury
rats.
A
uniform
dorsal
cut
was
formed
twenty-four
albino
rats,
which
were
arbitrarily
divided
into
4
groups
daily
with
topical
0.2
ml
dose
following:
group
A,
rats
received
10%
tween
20;
B,
intrasite
gel;
C
D,
had
250
500
mg/kg
APEAO,
respectively.
The
APEAO
treatment
did
cause
toxic
damage
administered
up
to
5
g/kg
APEAO.
In
experiment,
APEAO-treated
skin
exhibited
significantly
higher
deposition
tissue
collagen
fibroblast
cells.
contrast,
inflammatory
cells
lower
recovered
tissues
than
positve
control
Topical
application
caused
positive
modulation
Transforming
Growth
Factor
Beta
1
(angiogenesis)
skin,
indicating
elevated
growth
faster
action.
Moreover,
significant
elevation
antioxidants
(Superoxide
dismutase,
glutathione
peroxidase,
catalyze)
hydroxyproline
(collagen)
content,
lowering
Malondialdehyde
levels
compared
vehicle
Serum
chemicals
(Transforming
factor
α,
Interlukin-6,
Interlukin-10)
modulated
following
application.
outcomes
revealed
regeneration
potentials
by
modulatory
actions
several
cellular
processes,
could
serve
as
scientific
evidence
future
investigation
regarding
production
potent
pharmaceuticals
contraction.
Язык: Английский