Association between cathepsins and skin cancers: A bidirectional two‐sample Mendelian randomization study DOI Creative Commons

Xinyi Ma,

Haocheng Zhuang,

Mingze Xu

и другие.

Skin Research and Technology, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

Abstract Background Several cathepsins have been identified as being involved in the development of cancer. Nevertheless, connection between and skin cancers remained highly elusive. Methods A bidirectional Mendelian randomization (MR) analysis was performed to investigate causal association malignancies. The genome‐wide studies (GWAS) data for cathepsins, malignant melanoma (MM), basal cell carcinoma (BCC) were obtained from European research. primary method employed inverse variance weighted. In addition, MR‐Egger, weighted median, mode, simple mode also executed. Sensitivity using Cochran's Q test, MR‐PRESSO. Results From univariable MR (UVMR), cathepsin H, S determined a relationship with BCC. Additionally, H associated MM. Multivariable (MVMR) showed that after correcting risk factors carcinoma, detected be protective against BCC, whereas has observed factor No substantial pleiotropy heterogeneity sensitivity analysis. Conclusion This study first establish direct link Cathepsin potential serve new biomarkers offering valuable assistance prompt identification, treatment, prevention disease. additional clinical trials are required validate our findings.

Язык: Английский

Association between cathepsins and skin cancers: A bidirectional two‐sample Mendelian randomization study DOI Creative Commons

Xinyi Ma,

Haocheng Zhuang,

Mingze Xu

и другие.

Skin Research and Technology, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

Abstract Background Several cathepsins have been identified as being involved in the development of cancer. Nevertheless, connection between and skin cancers remained highly elusive. Methods A bidirectional Mendelian randomization (MR) analysis was performed to investigate causal association malignancies. The genome‐wide studies (GWAS) data for cathepsins, malignant melanoma (MM), basal cell carcinoma (BCC) were obtained from European research. primary method employed inverse variance weighted. In addition, MR‐Egger, weighted median, mode, simple mode also executed. Sensitivity using Cochran's Q test, MR‐PRESSO. Results From univariable MR (UVMR), cathepsin H, S determined a relationship with BCC. Additionally, H associated MM. Multivariable (MVMR) showed that after correcting risk factors carcinoma, detected be protective against BCC, whereas has observed factor No substantial pleiotropy heterogeneity sensitivity analysis. Conclusion This study first establish direct link Cathepsin potential serve new biomarkers offering valuable assistance prompt identification, treatment, prevention disease. additional clinical trials are required validate our findings.

Язык: Английский

Процитировано

1