Should We Transplant Candidates With a Positive SARS-CoV-2 RT-PCR Test? DOI
Iliès Benotmane,

Nathan Kasriel,

Christophe Masset

и другие.

Transplantation, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

It remains unclear whether physicians should accept transplantation offers for candidates with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test due to the potential risk of severe infection after initiating immunosuppressive therapy. A multicenter observational study was conducted in 19 French solid organ units. Patients on waiting list liver or kidney transplants who had nasopharyngeal swab at time were recorded. Sixty-five patients included. The recipients predominantly men (n = 40; 62%) mean age 55.4 y (SD 16.5). On day transplantation, 2 exhibited symptoms compatible COVID-19. majority 55; 85%) underwent thoracic imaging, only 3 showing imaging results Ten (28%) cycle threshold value <30. Anti-SARS-CoV-2 spike protein serology within mo before available 36 patients; seronegative. Due COVID-19, adapted therapy 16 (25%). Specific antiviral used 15 (23%), primarily remdesivir 12). Overall, did not receive any adjustment treatment 36; 55%). outcomes generally favorable even lowest values, indicating high viral load. Four died during follow-up, although none these deaths attributable Transplantation appears be safe are asymptomatic have mild symptoms, reassuring and history anti-SARS-CoV-2 and/or immunization.

Язык: Английский

Should We Transplant Candidates With a Positive SARS-CoV-2 RT-PCR Test? DOI
Iliès Benotmane,

Nathan Kasriel,

Christophe Masset

и другие.

Transplantation, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

It remains unclear whether physicians should accept transplantation offers for candidates with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test due to the potential risk of severe infection after initiating immunosuppressive therapy. A multicenter observational study was conducted in 19 French solid organ units. Patients on waiting list liver or kidney transplants who had nasopharyngeal swab at time were recorded. Sixty-five patients included. The recipients predominantly men (n = 40; 62%) mean age 55.4 y (SD 16.5). On day transplantation, 2 exhibited symptoms compatible COVID-19. majority 55; 85%) underwent thoracic imaging, only 3 showing imaging results Ten (28%) cycle threshold value <30. Anti-SARS-CoV-2 spike protein serology within mo before available 36 patients; seronegative. Due COVID-19, adapted therapy 16 (25%). Specific antiviral used 15 (23%), primarily remdesivir 12). Overall, did not receive any adjustment treatment 36; 55%). outcomes generally favorable even lowest values, indicating high viral load. Four died during follow-up, although none these deaths attributable Transplantation appears be safe are asymptomatic have mild symptoms, reassuring and history anti-SARS-CoV-2 and/or immunization.

Язык: Английский

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