Overview of autoantibodies in COVID‐19 convalescents
Journal of Medical Virology,
Год журнала:
2023,
Номер
95(6)
Опубликована: Июнь 1, 2023
Abstract
Accumulating
evidence
shows
that
SARS‐CoV‐2
can
potentially
trigger
autoimmune
processes,
which
be
responsible
for
the
long‐term
consequences
of
COVID‐19.
Therefore,
this
paper
aims
to
review
autoantibodies
reported
in
COVID‐19
convalescents.
Six
main
groups
were
distinguished:
(i)
against
components
immune
system,
(ii)
cardiovascular
(iii)
thyroid
autoantibodies,
(iv)
specific
rheumatoid
diseases,
(v)
antibodies
G‐protein
coupled
receptors,
and
(vi)
other
autoantibodies.
The
reviewed
here
clearly
highlights
infection
may
induce
humoral
responses.
However,
available
studies
share
number
limitations,
such
as:
(1)
sole
presence
does
not
necessarily
implicate
clinically‐relevant
risks,
(2)
functional
investigations
rarely
performed
it
is
often
unknown
whether
observed
are
pathogenic,
(3)
control
seroprevalence,
healthy,
noninfected
individuals
was
reported;
thus
sometimes
detected
result
or
accidental
post‐COVID‐19
detection,
(4)
correlated
with
symptoms
syndrome,
(5)
size
studied
small,
(6)
focused
predominantly
on
adult
populations,
(7)
age‐
sex‐related
differences
seroprevalence
explored,
(8)
genetic
predispositions
involved
generation
during
infections
investigated,
(9)
reactions
following
variants
vary
clinical
course
remain
unexplored.
Further
longitudinal
advocated
assess
link
between
identified
particular
outcomes
Язык: Английский
Anti-PF4 antibodies and their relationship with COVID infection
Hematology Transfusion and Cell Therapy,
Год журнала:
2024,
Номер
46(4), С. 516 - 523
Опубликована: Фев. 1, 2024
Detecting
anti-PF4
antibodies
remains
the
golden
diagnostic
method
for
heparin-induced
thrombocytopenia
(HIT)
diagnosis
with
high
sensitivity
and
specificity.
Various
lab
tests
detect
antibodies,
including
immunoassays
functional
assays.
Even
positive
detection
of
antibody,
several
factors
are
involved
in
result.
The
concept
disorders
was
recently
brought
to
light
during
COVID
pandemic
since
development
vaccine-induced
thrombotic
(VITT)
adenovirus-vectored-DNA
vaccine
pandemic.
Circumstances
that
classified
as
disorders,
VITT,
autoimmune
HIT
spontaneous
HIT.
Some
studies
showed
a
higher
percentage
antibody
among
population
infected
by
COVID-19
without
heparin
exposure
some
supported
theory
were
related
disease
severity.
In
this
review
article,
we
provide
brief
summarize
current
infection.
Язык: Английский
Results on SARS-CoV-2 mRNA Vaccine Booster from an Open-Label Multicenter Study in Ofatumumab-Treated Participants with Relapsing Multiple Sclerosis
Vaccines,
Год журнала:
2023,
Номер
11(5), С. 978 - 978
Опубликована: Май 13, 2023
Background:
Few
data
exist
on
how
ofatumumab
treatment
impacts
SARS-CoV-2
booster
vaccination
response.
Methods:
KYRIOS
is
an
ongoing
prospective
open-label
multicenter
study
the
response
to
initial
and
mRNA
before
or
during
in
relapsing
MS
patients.
The
results
cohort
have
been
published
previously.
Here,
we
describe
23
patients
who
received
their
outside
of
but
study.
Additionally,
report
two
cohort.
primary
endpoint
was
SARS-CoV-2-specific
T-cell
at
month
1.
Furthermore,
serum
total
neutralizing
antibodies
were
measured.
Results:
reached
by
87.5%
with
(booster
1,
N
=
8)
46.7%
2,
15).
Seroconversion
rates
for
increased
from
baseline
100.0%
1
71.4%
93.3%
2.
Of
note,
3
4
initially
seronegative
2
one
patient
seroconverted
after
treatment.
Conclusions:
Booster
vaccinations
increase
antibody
titers
ofatumumab-treated
A
recommended
Язык: Английский
Abnormal proteolytic activity profile in plasma of blood donors according to anti-SARS-CoV-2 IgG titer
Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
This
work
aims
to
study
whether
there
is
a
relationship
between
titer
values
of
anti-SARS-CoV-2
IgG
and
changes
in
proteolytic
processes.
To
confirm
this
hypothesis,
we
analyzed
the
content
activity
Matrix
Metalloproteinases
(MMPs)
as
well
concentration
composition
circulating
peptide
pools
plasma
blood
donors
divided
into
groups
on
basis
titers.
The
results
gelatin
zymography
showed
presence
active
MMP-2
donors’
who
recovered
from
COVID-19.
In
contrast,
collagenases
their
complexes
were
detected
with
no
IgG,
while
was
undetectable
some
COVID-19
convalescent
individuals.
MMPs
also
differed
among
different
titers
IgG.
Plasma
identical
donors'
groups,
but
more
fractions
individuals;
furthermore,
they
all
characterized
by
peptides
molecular
weights
less
than
920
Da
greater
1530
Da.
We
hypothesized
link
alterations
fraction
composition.
Our
data
need
further
validation
severity
imbalance.
Язык: Английский