Chemical Constituents of Stinging Nettle (Urtica dioica L.): A Comprehensive Review on Phenolic and Polyphenolic Compounds and Their Bioactivity

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3430 - 3430

Опубликована: Март 18, 2024

Polyphenolic compounds are of great interest in today’s science. Naturally, they occur plants and other sources many different forms. Their wide range biological activity has attracted the attention scientific community. One phenolic is stinging nettle (Urtica dioica L.), a common plant almost all parts world. A long tradition utilization an interesting chemical profile make this fascinating extensive object study. The also allows to be used as food pigment source food, pharmaceutical, cosmetic industries. Previously conducted studies found acids polyphenolic root, stalk, leaves. Different extraction techniques were usually isolate them from Obtained extracts investigate further or formulate functional products. This study aimed collect available knowledge about plant, its composition, summarize with particular mechanisms their actions.

Язык: Английский

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Phenolic Compounds Profiling and Their Antioxidant Capacity in the Peel, Pulp, and Seed of Australian Grown Avocado

Antioxidants, Год журнала: 2023, Номер 12(1), С. 185 - 185

Опубликована: Янв. 12, 2023

Avocados (Persea americana M.) are highly valued fruits consumed worldwide, and there numerous commercially available varieties on the market. However, high demand for fruit also results in increased food waste. Thus, this study was conducted comprehensive profiling of polyphenols Hass, Reed, Wurtz avocados obtained from Australian local Ripe Hass peel recorded highest TPC (77.85 mg GAE/g), TTC (148.98 CE/g), DPPH (71.03 AAE/g), FRAP (3.05 RPA (24.45 ABTS (75.77 AAE/g) values; unripe TFC (3.44 QE/g); TAC (35.02 AAE/g). Correlation analysis revealed that were significantly correlated with antioxidant capacity extracts. A total 348 screened peel. 134 compounds including 36 phenolic acids, 70 flavonoids, 11 lignans, 2 stilbenes, another 15 polyphenols, characterised through LC-ESI-QTOF-MS/MS, where majority peels seeds samples extract. Overall, hierarchical heat map a significant amount seeds. Epicatechin, kaempferol, protocatechuic acid showed higher concentrations Reed pulp. contains concentration hydroxybenzoic acid. Our avocado wastes have considerable exhibiting activities. Each sample has its unique value proposition based profile. This may increase confidence utilising by-products encourage further investigation into as nutraceuticals.

Язык: Английский

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Mechanisms of action of coffee bioactive compounds – a key to unveil the coffee paradox

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(28), С. 10164 - 10186

Опубликована: Июнь 20, 2023

The knowledge of the relationship between chemical structure food components with their mechanisms action is crucial for understanding diet health benefits. This review relates variability present in coffee beverages involved key physiological events, supporting as a polyvalent functional food. Coffee intake has been related several health-promoting properties such neuroprotective (caffeine, chlorogenic acids and melanoidins), anti-inflammatory acids, melanoidins, diterpenes), microbiota modulation (polysaccharides, acids), immunostimulatory (polysaccharides), antidiabetic (trigonelline, antihypertensive (chlorogenic acids) hypocholesterolemic lipids). Nevertheless, caffeine diterpenes are ambivalent effects on health. Additionally, large range potentially harmful compounds, including acrylamide, hydroxymethylfurfural, furan, advanced glycation end products, formed during roasting beverages. However, part daily human dietary healthy habits, configuring paradox.

Язык: Английский

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Anti-inflammatory in vitro activities of eleven selected caffeic acid derivatives based on a combination of pro−/anti-inflammatory cytokine secretions and principal component analysis – A comprehensive evaluation

Food Chemistry, Год журнала: 2024, Номер 458, С. 140201 - 140201

Опубликована: Июнь 25, 2024

Язык: Английский

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Unraveling the genetic architecture of blueberry fruit quality traits: major loci control organic acid content while more complex genetic mechanisms control texture and sugar content

BMC Plant Biology, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 10, 2025

Fruit quality traits, including taste, flavor, texture, and shelf-life, have emerged as important breeding priorities in blueberry (Vaccinium corymbosum). Organic acids sugars play crucial roles the perception of taste/flavor, where low high consumer liking are correlated with organic sugars, respectively. Blueberry texture appearance also critical for shelf-life consumers' willingness-to-pay. As genetic mechanisms that determine these fruit traits remain largely unknown, this study, an F1 mapping population was used to perform quantitative trait loci (QTL) pH, titratable acidity (TA), acids, total soluble solids (TSS), size, at harvest and/or post-storage weight loss. Twenty-eight QTLs were detected acidity-related parameters (pH, TA, acid content). Six citric acid, two quinic shikimic major effects consistently across years on same genomic regions chromosomes 3, 4, 5, Putative candidate genes identified using comparative transcriptomic analysis. No QTL malic content, TSS, or individual sugar content. A 146 minor texture- size-related parameters. With a few exceptions, generally inconsistent over post-storage, indicating highly nature. Our findings enhance understanding basis underlying guide future work exploit DNA-informed selection strategies programs. The major-effect characteristics could be potential targets develop DNA markers marker-assisted (MAS). On other hand, may more suitable approach than MAS when targeting size.

Язык: Английский

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Exploiting natural products to discover multitarget inhibitors of insect chitinolytic enzymes

Advanced Agrochem, Год журнала: 2023, Номер 2(4), С. 306 - 312

Опубликована: Июль 18, 2023

Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a low risk resistance. Insect chitinolytic enzymes, including GH18 chitinases and GH20 β-N-acetyl-d-hexosaminidase, attractive targets for multitarget insecticide design by virtue their similar substrate binding mode catalytic mechanism. On the other hand, natural products diverse skeletal structures potential repositories enzyme inhibitors. This minireview first presents theoretical basis developing multitargeted inhibitors against insect enzymes then focuses on progress in derived from products. These may provide ideas exploitation novel pesticide leads targeting multiple targets.

Язык: Английский

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Rapid evolutionary trade‐offs between resistance to herbivory and tolerance to abiotic stress in an invasive plant

Ecology Letters, Год журнала: 2023, Номер 26(6), С. 942 - 954

Опубликована: Апрель 19, 2023

Abstract Release from enemies can lead to rapid evolution in invasive plants, including reduced metabolic investment defence. Conversely, reassociation with leads renewed of defence, but the potential costs this are poorly documented. We report increased resistance invader Ambrosia artemisiifolia after a coevolved specialist herbivore, and that increase corresponds abiotic stress tolerance. Herbivore was higher, drought tolerance lower plants populations longer history, corresponded changes phenylpropanoids involved insect These were corroborated by shifts expression underlying biosynthetic genes plant anti‐oxidants. Together, our findings suggest traits enemies, resulting genetically based between biotic responses, providing insights into co‐evolution, invasion biological control.

Язык: Английский

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Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 27, 2024

Abstract Species from genus Artemisia are widely distributed throughout temperate regions of the northern hemisphere and many cultures have a long-standing traditional use these plants as herbal remedies, liquors, cosmetics, spices, etc. Nowadays, discovery new plant-derived products to be used food supplements or drugs has been pushed by exploitation bioprospection approaches. Often driven knowledge derived ethnobotanical plants, explores existing biodiversity through integration modern omics techniques with targeted bioactivity assays. In this work we set up plan investigate phytochemical diversity potential five species recognized tradition ( A. absinthium , alba annua verlotiorum vulgaris ), growing wild in natural areas Verona province. We characterized specialized metabolomes (including sesquiterpenoids artemisinin biosynthesis pathway) an LC–MS based untargeted approach and, order identify bioactive metabolites, correlated their composition vitro antioxidant activity. propose compounds several isomers caffeoyl feruloyl quinic acid esters (e.g. dicaffeoylquinic acids, feruloylquinic acids caffeoylferuloylquinic acids), which strongly characterize most . Morevoer, study report for first time occurrence pathway

Язык: Английский

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Anticancer Therapies Based on Oxidative Damage: Lycium barbarum Inhibits the Proliferation of MCF-7 Cells by Activating Pyroptosis through Endoplasmic Reticulum Stress

Antioxidants, Год журнала: 2024, Номер 13(6), С. 708 - 708

Опубликована: Июнь 11, 2024

Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also an important source of bioactive compounds such polysaccharides, carotenoids, phenolics, various other non-nutritive compounds. These constituents give it a multitude health benefits, including antioxidant, anti-inflammatory, anticancer properties. However, the precise biochemical mechanisms responsible effects remain unclear, comprehensive composition extracts often insufficiently explored. This study aimed to investigate pathways modulated in breast cancer cells by ethanolic extract barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed antitumoral LBE on different cell lines. investigation revealed that exhibited cytotoxic effects, inducing pro-oxidant effect triggered pyroptosis activation through endoplasmic reticulum (ER) stress subsequent P-IRE1α/XBP1/NLRP3 axis MCF-7 cells. In addition, did display cytotoxicity toward healthy human demonstrated antioxidant neutralizing ROS generated doxorubicin. findings underscore potential promising natural therapy.

Язык: Английский

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Nutritional Profile, Chemical Composition and Health Promoting Properties of Salicornia emerici Duval-Jouve and Sarcocornia alpini (Lag.) Rivas Mart. from Southern Tunisia

Biocatalysis and Agricultural Biotechnology, Год журнала: 2025, Номер unknown, С. 103502 - 103502

Опубликована: Янв. 1, 2025

Язык: Английский

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