The Plant Journal, Год журнала: 2023, Номер 114(5), С. 999 - 1000
Опубликована: Май 30, 2023
There has been a resurgence of interest in plant metabolic systems driven by research projects aiming to re-engineer metabolism for improvement the efficiency and productivity crops. is also growing understanding more general importance signalling during development. While there have many reviews on crop aspects engineering, fundamentals regulation somewhat overlooked despite key advances multiple fronts. This TPJ special issue gathers 11 high-impact that cover all regulation, from gene expression, protein degradation, protein–protein interaction, redox processes allostery, as well responses specific nutrients cofactors. The contains developmental metabolism, cell type-specific specialised epigenome within between plants other organisms. Here we provide brief overview each review. Interaction emerged an important mechanism which may be brought about. review Lu et al. (2023) tackles metabolites, detailing how primary intermediates such S-adenosyl methionine, acetyl-CoA, alpha-ketoglutarate NAD+ are required substrates or cofactors chromatin modification. It provides insight into this, turn, controls cellular metabolism. As this thoroughly modern control growth. In doing so it sets scene beautifully rest issue. continues with three articles define our current role enzyme cofactors, effectors post-translational modifications regulation. first these, da Fonseca-Pereira explain several some were already defined epigenetic regulators, regulate They comprehensive physiological known participates. illustrate cofactor highlighting recent discoveries regarding broad range stress-related contexts. Similar allosteric long history. their article, Hartmann briefly describe history but place main focus discussing classical biochemical studies can best married post-genomic techniques study proteomics. choose eight pathways this. they chronicle allosterically regulated enzymes pathway defining novel identifying protein–metabolite interactions. complementary article Balparda extent regulatory impact modification process photosynthetic carbon assimilation. By focusing examples where empirical evidence functional changes associated modification, demonstrate only at beginning deciphering network. Another aspect spatiotemporal coupling sequential enzymes. Such dynamic enzyme–enzyme interactions studied almost 50 years plants. Over time particular placed assemblies metabolons perform substrate channelling. described Dahmani (2023), four unambiguously due difficulty obtaining supporting evidence. used suggest developments offer appropriate strategies identify metabolons. advocate field should aim become quantitative better integrated biology order deeper types cells present require matches fluxes demands those different types. review, Daloso difficulties information landscape distinct technical limitations ability rapidly purify one type another manner individual not perturbed. methods applied, namely isolation, situ microscopy silico modelling. Finally, discuss factors affect flux distribution detail augur future feature multicellular At whole level, long-standing question growth coordinated. Cai long-distance metabolite signals orchestrate differential patterns tissues. so, detailed inventory suggesting could found. knowledge engineer improved health resilience. development quiescence, division repressed reversible manner. actively monitored influenced environmental stimuli. Considine Foyer quiescence tuned energy, nutrient oxygen status sense transmit these signals. argue mitochondrial function intrinsic reactive species play orchestration quiescence. final collection engineering natural products, defence philosophical whether approach network perspective. Selma multigene including editing transcriptional approaches. technologies uncharacterised biosynthetic pathways, degradation mechanisms, interaction feedback synthesis routes inform attempts improve product synthesis. metabolites its defence. much focused volatile organic compounds context, Luo non-volatile insect herbivores. interplay nutritional core defensive noting ‘that feeding tends elicit evolutionarily conserved specialized whereas effect varies widely based interacting species’. vast gap perspective filled emergent technologies. end Lanier uses terpene case address fact rarely look simple linear when rather complex intertwined networks. For purpose, encompassing genomics transformative view indeed far advanced genome era reinforces fundamental genetic foundations laid last century.
Язык: Английский
