Physiology of ageing skeletal muscle and the protective effects of exercise

The Journal of Physiology, Год журнала: 2025, Номер 603(1), С. 3 - 6

Опубликована: Янв. 1, 2025

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Язык: Английский

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The Mitochondria‐Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age

Aging Cell, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

ABSTRACT Aging‐related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondria‐targeted peptide, has demonstrated broad therapeutic efficacy ameliorating disease conditions mitochondrial dysfunction across both clinical pre‐clinical models. Herein, we investigated the impact of 8‐week ELAM treatment on pre‐ post‐measures C57BL/6J mice frailty, muscle, function, coupled post‐treatment assessments biological age affected molecular pathways. We found that health status, as measured by frailty index, strain, diastolic force, is significantly diminished age, force changing sex‐dependent manner. Conversely, mitigated accumulation was able to partially reverse these declines, evidenced treatment‐induced increases strain fatigue resistance. Despite improvements, did not detect statistically significant changes gene expression or DNA methylation profiles indicative reorganization reduced most ELAM‐treated groups. However, pathway analyses revealed showed pro‐longevity shifts expression, such upregulation genes involved fatty acid metabolism, translation, oxidative phosphorylation, downregulation inflammation. Together, results indicate effective at mitigating signs sarcopenia an aging mouse model, but functional improvements occur independently detectable epigenetic transcriptomic age. Thus, some age‐related may be uncoupled from

Язык: Английский

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Geroprotector drugs and exercise: friends or foes on healthy longevity?

BMC Biology, Год журнала: 2023, Номер 21(1)

Опубликована: Дек. 8, 2023

Abstract Physical activity and several pharmacological approaches individually combat age-associated conditions extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotector drugs with exercise could beyond any individual treatment. However, the current dogma suggests taking leading on same day as may limit health benefits. Here, we review candidate their interactions highlight salient gaps knowledge need be addressed identify if can have a harmonious relationship exercise.

Язык: Английский

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Gender Differences in the Impact of a High-Fat, High-Sugar Diet in Skeletal Muscles of Young Female and Male Mice

Nutrients, Год журнала: 2024, Номер 16(10), С. 1467 - 1467

Опубликована: Май 13, 2024

In the context of increasing number obese individuals, a major problem is represented by obesity and malnutrition in children. This condition mainly ascribable to unbalanced diets characterized high intakes fat sugar. Childhood are not only associated with concurrent pathologies but potentially compromise adult life. Considering strict correlation among systemic metabolism, obesity, skeletal muscle health, we wanted study impact juvenile on muscle. To this aim, 3-week-old C56BL/6 female male mice were fed for 20 weeks high-fat. high-sugar diet, their muscles subjected histological evaluation. MyHCs expression, glycogen content, intramyocellular lipids, mitochondrial activity, capillary density analyzed serial sections obtain metabolic profile. Our observations indicate that high-fat, diet alters profile sex-dependent way induces increase type II fibers, lipid content males, while reducing females. These data highlight response nutrition, calling development specific strategies systematic inclusion subjects basic applied research field.

Язык: Английский

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Mitochondria in skeletal system-related diseases

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 181, С. 117505 - 117505

Опубликована: Ноя. 4, 2024

Язык: Английский

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Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(24), С. 7625 - 7625

Опубликована: Дек. 11, 2023

Temporal muscle thickness (TMT) on cranial CT scans has recently been identified as a prognostic imaging parameter for assessing patient's baseline frailty. Here, we analyzed whether TMT correlates with Traumatic brain injury (TBI) severity and it can be used to predict outcome(s) after TBI. We the radiological clinical data sets of 193 patients TBI who were admitted our institution correlated outcomes stratification TMT. Our analyses showed significant association between high increased risk intracranial hemorrhage (p = 0.0135) but improved mRS at 6 months 0.001) compared low Congruent such findings, lower was associated falls reduced < 0.0001 p 0.0001). High robustly head trauma sequelae also good in patients. These findings consolidate significance an objective marker frailty patients; measurements may ultimately leveraged indicators.

Язык: Английский

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Bone morphogenetic protein signaling inhibitor improves differentiation and function of 3D muscle construct fabricated using C2C12

Journal of Bioscience and Bioengineering, Год журнала: 2024, Номер 137(6), С. 480 - 486

Опубликована: Апрель 10, 2024

Язык: Английский

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The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide, has demonstrated broad therapeutic efficacy ameliorating disease conditions mitochondrial dysfunction across both clinical pre-clinical models. ELAM is proposed to restore bioenergetic by stabilizing inner membrane structure increasing oxidative phosphorylation coupling efficiency. Although treatment effectively attenuates physiological declines multiple tissues rodent aging models, it remains unclear whether these functional improvements correlate favorable changes molecular biomarkers of aging. Herein, we investigated the impact 8-week on pre- post- measures C57BL/6J mice frailty, muscle, function, coupled post-treatment assessments biological age affected pathways. We found that health status, as measured frailty index, strain, diastolic force significantly diminished age, changing sex-dependent manner. Conversely, mitigated accumulation was able partially reverse declines, evidenced treatment-induced increases strain fatigue resistance. Despite improvements, did not detect statistically significant gene expression or DNA methylation profiles indicative reorganization reduced most ELAM-treated groups. However, pathway analyses revealed showed pro-longevity shifts such upregulation genes involved fatty acid metabolism, translation phosphorylation, downregulation inflammation. Together, results indicate effective at mitigating signs sarcopenia heart failure an mouse model, but occur independently detectable epigenetic transcriptomic age. Thus, some age-related may be uncoupled from

Язык: Английский

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Age‐related changes of skeletal muscle metabolic response to contraction are also sex‐dependent

The Journal of Physiology, Год журнала: 2023, Номер 603(1), С. 33 - 35

Опубликована: Дек. 27, 2023

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Язык: Английский

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Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

SOD2 knockdown and recovery is achieved in skeletal muscle by using a shRNA targeted to mRNA controlled tetracycline Response Element reverse transactivator proteinSOD2 KD induced administering doxycycline the drinking waterMitochondrial functional decline follows time course of protein recoverySustained precipitates reduced metabolic flexibility mitochondria characterized impaired pyruvate respiration presence other substrates.

Язык: Английский

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