Vasohibins in Health and Disease: From Angiogenesis to Tumorigenesis, Multiorgan Dysfunction, and Brain–Heart Remodeling DOI Creative Commons
Ghulam Abbas, Annet Kirabo,

Usama Ahmed

и другие.

Cells, Год журнала: 2025, Номер 14(11), С. 767 - 767

Опубликована: Май 23, 2025

Vasohibins (VASHs), comprising VASH-1 and VASH-2, were initially identified as regulators of angiogenesis. Recent studies, however, have unveiled their novel role in fibrosis microtubule detyrosination. The dysregulated expression VASHs is associated with several pathological processes, such angiogenesis dysfunction, detyrosination, fibrosis, contributing to various diseases. These findings suggest the pleiotropic effects multiple organs systems beyond This review explores molecular properties emerging functions tubulin carboxyl activity detyrosination—key brain cardiac remodeling. We also discuss potential therapeutic applications interference diseases tumorigenesis, well renal-, reproductive-, liver-related

Язык: Английский

Vasohibins in Health and Disease: From Angiogenesis to Tumorigenesis, Multiorgan Dysfunction, and Brain–Heart Remodeling DOI Creative Commons
Ghulam Abbas, Annet Kirabo,

Usama Ahmed

и другие.

Cells, Год журнала: 2025, Номер 14(11), С. 767 - 767

Опубликована: Май 23, 2025

Vasohibins (VASHs), comprising VASH-1 and VASH-2, were initially identified as regulators of angiogenesis. Recent studies, however, have unveiled their novel role in fibrosis microtubule detyrosination. The dysregulated expression VASHs is associated with several pathological processes, such angiogenesis dysfunction, detyrosination, fibrosis, contributing to various diseases. These findings suggest the pleiotropic effects multiple organs systems beyond This review explores molecular properties emerging functions tubulin carboxyl activity detyrosination—key brain cardiac remodeling. We also discuss potential therapeutic applications interference diseases tumorigenesis, well renal-, reproductive-, liver-related

Язык: Английский

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