Deep Neural Network-Based Sinogram Super-Resolution and Bandwidth Enhancement for Limited-Data Photoacoustic Tomography

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Год журнала: 2020, Номер 67(12), С. 2660 - 2673

Опубликована: Фев. 28, 2020

Photoacoustic tomography (PAT) is a noninvasive imaging modality combining the benefits of optical contrast at ultrasonic resolution. Analytical reconstruction algorithms for photoacoustic (PA) signals require large number data points accurate image reconstruction. However, in practical scenarios, are collected using limited transducers along with being often corrupted noise resulting only qualitative images. Furthermore, boundary band-limited due to bandwidth (BW) transducer, making PA qualitative. In this work, deep neural network-based model loss function scaled root-mean-squared error was proposed super-resolution, denoising, as well BW enhancement domain. The network has been compared traditional other popular deep-learning methods numerical experimental cases and shown improve data, turn, providing superior quality reconstructed image. improvement obtained Pearson correlation, structural similarity index metric, root-mean-square high 35.62%, 33.81%, 41.07%, respectively, phantom signal-to-noise ratio images 11.65 dB vivo original data. Code available https://sites.google.com/site/sercmig/home/dnnpat.

Язык: Английский

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Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures

Sensors, Год журнала: 2018, Номер 18(5), С. 1394 - 1394

Опубликована: Май 1, 2018

Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of medical device and procedure’s target often challenging. Photoacoustic has shown great promise for guiding clinical translation this technology been limited by bulky expensive excitation sources. In work, we demonstrate feasibility procedures using a dual-mode photoacoustic ultrasound system with from compact arrays light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, metal needles inserted into biological tissue imaged. Second, depth was characterized blood-vessel-mimicking phantom. Third, superficial vasculature in human volunteers It found that enabled needle signal-to-noise ratios 1.2 2.2 times higher than those obtained imaging, over insertion angles 26 51 degrees. With blood vessel mimicking phantom, maximum 38 mm. The middle finger wrist clearly visualized real-time. We conclude LED-based promising peripheral targets.

Язык: Английский

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Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon

Frontiers in Physics, Год журнала: 2020, Номер 8

Опубликована: Апрель 9, 2020

The frontiers of bioimaging are currently being pushed towards the integration and correlation several modalities to tackle biomedical research questions holistically across multiple scales. Correlated Multimodal Imaging (CMI) gathers information about exactly same specimen with two or more complementary that – combined create a composite view sample (including insights into structure, function, dynamics molecular composition). CMI allows describe processes within their overall spatio-temporal context gain mechanistic understanding cells, tissues, diseases organisms by untangling mechanisms native environment. best-established implementations hardware-fused platforms in (Pre)clinical (Hybrid Imaging) Light Electron Microscopy (CLEM) biological imaging. Although merits Hybrid CLEM well established, both approaches would benefit from standardization protocols, ontologies data handling, development optimized advanced implementations. Specifically, pipelines aim at bridging preclinical imaging beyond rare but bear great potential substantially advance research. faces three main challenges for its routine use research: (1) Sample handling preparation procedures compatible without compromising quality, (2) soft- hardware solutions relocate region interest (ROI) after transfer between including fiducial markers, (3) automated software correlate complex, multiscale, multimodal volumetric image reconstruction, segmentation visualization. This review goes puts accessible broader context. We present comprehensive overview field PHI correlative microscopy, highlight requirements optimization standardization, synopsis current focus on efforts bridge gap is line major European initiatives, such as COMULIS (CA17121), COST Action promote foster Life Sciences.

Язык: Английский

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Towards non-contact photoacoustic imaging [review]

Photoacoustics, Год журнала: 2020, Номер 20, С. 100207 - 100207

Опубликована: Сен. 23, 2020

Photoacoustic imaging (PAI) takes advantage of both optical and ultrasound properties to visualize absorption with high resolution contrast. microscopy (PAM) is usually categorized all-optical techniques such as coherence tomography or confocal microscopes. Despite offering sensitivity, novel contrast, resolution, PAM not generally an method unlike the other techniques. One significant limitations photoacoustic microscopes arises from their need be in physical contact sample through a coupling media. This contact, coupling, immersion undesirable impractical for many clinical pre-clinical applications. also limits flexibility integrated providing complementary To overcome these limitations, several non-contact signal detection approaches have been proposed. paper presents brief overview current emphasis on methods associated mechanisms.

Язык: Английский

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Microvascular imaging of the skin

Physics in Medicine and Biology, Год журнала: 2019, Номер 64(7), С. 07TR01 - 07TR01

Опубликована: Фев. 1, 2019

Despite our understanding that the microvasculature plays a multifaceted role in development and progression of various conditions, we know little about extent this involvement. A need exists for non-invasive, clinically meaningful imaging modalities capable elucidating microvascular information to aid disease, diagnosis/monitoring disease more patient-specific care. In review article, number techniques are summarized have been utilized investigate skin, along with their advantages, disadvantages future perspectives preclinical clinical settings. These include dermoscopy, capillaroscopy, Doppler sonography, laser flowmetry (LDF) perfusion imaging, speckle contrast (LSCI), optical coherence tomography (OCT), including its dynamic variant recently developed OCT angiography (OCTA), photoacoustic spatial frequency domain (SFDI). Attention is largely, but not exclusively, placed on use intrinsic signals microvasculature. We conclude whilst each modality has successful filling particular niche, there no one, all-encompassing without inherent flaws. Therefore, cutaneous may lie utilizing multi-modal approach will counter individual systems synergistically augment capabilities.

Язык: Английский

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