A review on time domain diffuse optics: principles and applications on human biological tissues
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
The
term
diffusive
media
refers
to
all
the
for
which
photon
diffusion
equation
provides
an
accurate
description
of
light
propagation.
Indeed,
this
is
case
a
plethora
natural
media,
such
as
biological
tissues
and
agricultural
products,
when
illuminated
by
red
near-infrared
light.
Diffuse
Optics
(DO)
branch
that
studies
how
absorption
scattering
phenomena
affect
propagation
in
media.
In
review
paper,
we
present
introduction
time
domain
(TD)
DO,
specific
implementation
DO
employs
picosecond
pulses,
fast
sensitive
photodetectors
timing
electronics
record
distribution
time-of-flight
(or
path
lengths)
By
interpreting
TD
signals
with
physical
model
provided
theory,
it
possible
estimate
properties
medium
can
be
related
physiological
pathological
conditions.
We
focus
on
principles
building
blocks
instrumentation,
applications
targeting
human
(such
brain,
breast,
muscle,
others).
Язык: Английский
HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation
Journal of Biomedical Optics,
Год журнала:
2024,
Номер
29(01)
Опубликована: Янв. 24, 2024
SignificanceHyperspectral
time-resolved
(TR)
near-infrared
spectroscopy
offers
the
potential
to
monitor
cytochrome-c-oxidase
(oxCCO)
and
blood
oxygenation
in
adult
brain
with
minimal
scalp/skull
contamination.
We
introduce
a
hyperspectral
TR
spectrometer
that
uses
compressive
sensing
minimize
acquisition
time
without
compromising
spectral
range
or
resolution
demonstrate
oxCCO
monitoring
deep
tissue.AimDevelop
use
it
tissue.ApproachHomogeneous
tissue-mimicking
phantom
experiments
were
conducted
confirm
spectrometer’s
sensitivity
oxygenation.
Two-layer
phantoms
used
evaluate
bottom
layer
through
10
mm
thick
static
top
layer.ResultsThe
was
sensitive
changes
of
two-layer
phantoms,
as
confirmed
by
concomitant
measurements
acquired
directly
from
layer.
Measures
highly
correlated
“gold
standard”
measures
homogeneous
experiments.ConclusionsThe
results
show
is
tissue
Язык: Английский