Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 6, 2023

Abstract Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005–0.02 Hz), neurogenic (N; 0.02–0.04 and myogenic (M; 0.04–0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive PFC. Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Язык: Английский

Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 3, 2024

Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005-0.02 Hz), neurogenic (N; 0.02-0.04 and myogenic (M; 0.04-0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive (PFC). Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Язык: Английский

Процитировано

4
Quantification and stimulation of human glymphatic dynamics:New features of Alzheimer’s disease and effects of brain photobiomodulation DOI Creative Commons

Fiza Saeed,

Kathy L. Siepker,

Soeun Jang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

A non-invasive device to measure the dynamics of cerebrospinal fluid (CSF) is highly desirable because CSF facilitates cleaning neurotoxic wastes in brain. better understanding helps promote healthy aging older adults and treat patients with neurological diseases. This study employed a multi-color optical method quantify prefrontal two groups: (1) (n = 16) without 27) Alzheimer's disease (2) young 26) before after light stimulation. The results revealed that coupling strengths between cerebral blood volume (CBV) were age-dependent significantly higher AD than controls. Prefrontal stimulation enhanced CBV-CSF coupling, suggesting improved drainage. underscores strategy as unique tool for monitoring interaction CBV CSF, well metabolic functions human brain, while demonstrating therapeutic potential brain treating neurodegenerative diseases involving drainage dysfunction.

Язык: Английский

Процитировано

0
Unilateral Mitochondrial–Hemodynamic Coupling and Bilateral Connectivity in the Prefrontal Cortices of Young and Older Healthy Adults DOI Creative Commons

Claire Sissons,

Fiza Saeed,

Caroline Carter

и другие.

Bioengineering, Год журнала: 2023, Номер 10(11), С. 1336 - 1336

Опубликована: Ноя. 20, 2023

A recent study demonstrated that noninvasive measurements of cortical hemodynamics and metabolism in the resting human prefrontal cortex can facilitate quantitative metrics unilateral mitochondrial–hemodynamic coupling bilateral connectivity infraslow oscillation frequencies young adults. The includes three distinct vasomotions with endogenic (E), neurogenic (N), myogenic (M) frequency bands. goal this was to prove hypothesis there are significant differences between older adults (uCOP) (bCON) cortex. Accordingly, we performed from 24 (67.2 ± 5.9 years age) using same two-channel broadband near-infrared spectroscopy (bbNIRS) setup resting-state experimental protocol as those study. After quantification uCOP bCON E/N/M statistical analysis, had significantly weaker hemodynamic but stronger metabolic than M band. Furthermore, exhibited on both sides all bands, particularly a very large effect size band (>1.9). These age-related results clearly support our were well interpreted following neurophysiological principles. key finding paper is highly associated age may have potential become meaningful features for brain health be translatable future clinical applications, such early detection Alzheimer’s disease.

Язык: Английский

Процитировано

2
Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults DOI Open Access

Claire Sissons,

Fiza Saeed,

Caroline Carter

и другие.

Опубликована: Авг. 29, 2023

A recent study demonstrated that noninvasive measurements of cortical hemodynamics and metabolism in the resting human prefrontal cortex can facilitate quantitative metrics unilateral mitochondrial-hemodynamic coupling bilateral connectivity infraslow oscillation (ISO) frequencies young adults (YA). The ISO includes three distinct vasomotions with endogenic (E), neurogenic (N), myogenic (M) frequency bands. goal this was to prove hypothesis there are significant differences between older (OA) (uCOP) (bCON) cortex. Accordingly, we performed from 24 OA (67.2 ± 5.9 years age) using same 2-channel broadband near-infrared spectroscopy (bbNIRS) setup resting-state experimental protocol as those (Shahdadian et al, Cerebral Cortex Communications, 2022). After quantification uCOP bCON E/N/M statistical analysis, had significantly weaker hemodynamic but stronger metabolic than YA M band. Furthermore, exhibited on both sides all bands, particularly a very large effect size band (> 1.9). These age-related results clearly support our were well interpreted following neurophysiological principles. key finding paper is highly associated age may have potential become meaningful features for brain health be translatable future clinical applications, such early detection Alzheimer’s disease.

Язык: Английский

Процитировано

1
Continuous transcranial LED illumination alters human brain haemodynamics and oxygenation assessed by near-infrared spectroscopy DOI
Nagesh C. Shanbhag,

Jari Paunonen,

Hany Ferdinando

и другие.

Опубликована: Июнь 18, 2024

Transcranial photobiomodulation (tPBM) has emerged as a promising economical point-of-care tool to enhance mitochondrial dynamics, mitigate neuroinflammation, improve sleep and cognitive functions in various CNS disorders. Its propensity modulate cerebrovascular tone can potentially alter cerebral hemodynamics. We set out investigate whether tPBM influence the brain oxygenation assessed by fNIRS healthy subjects with body positional challenge.

Язык: Английский

Процитировано

0
Understanding metabolic responses to forearm arterial occlusion measured with two-channel broadband near-infrared spectroscopy DOI Creative Commons

Fiza Saeed,

Caroline Carter,

John O. Kolade

и другие.

Journal of Biomedical Optics, Год журнала: 2024, Номер 29(11)

Опубликована: Ноя. 29, 2024

SignificanceBroadband near-infrared spectroscopy (bbNIRS) is useful for the quantification of cerebral metabolism. However, its usefulness has not been explored broad biomedical applications.AimWe aimed to quantify dynamic responses oxidized cytochrome c oxidase (Δ[oxCCO]) within mitochondria arterial occlusion and correlations between hemodynamic (Δ[HbO]) Δ[oxCCO] during after in forearm tissues.ApproachWe recruited 14 healthy participants with two-channel bbNIRS measurements response a 5-min occlusion. The system consisted one shared white-light source two spectrometers. modified Beer-Lambert law was applied determine occlusion-induced changes Δ[HbO] shallow- deep-tissue layers.ResultsDuring occlusion, hemodynamics exhibited expected changes, but remained constant, as observed 1- 3-cm channels. A linear correlation only recovery phase, stronger deeper tissues. observation constant cuff period consistent previous reports. interpretation this based on literature that oxygen metabolism skeletal muscle remains unchanged before all oxy-hemoglobin (and oxy-myoglobin) resources are completely depleted. Because adequate exhaust supply vascular bed forearm, local maintains redox uninterrupted by occlusion.ConclusionsWe provide better understanding mitochondrial demonstrate bbNIRS.

Язык: Английский

Процитировано

0
Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 6, 2023

Abstract Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005–0.02 Hz), neurogenic (N; 0.02–0.04 and myogenic (M; 0.04–0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive PFC. Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Язык: Английский

Процитировано

0