Translational Psychiatry,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 21, 2025
Anhedonia,
as
one
of
the
core
symptoms
major
depressive
disorder
(MDD),
has
been
regarded
a
potential
endophenotype
disease.
Multiple
studies
have
evaluated
mechanisms
anhedonia
in
MDD,
and
found
that
MDD
patients
with
showed
different
functions
clinical
features.
In
this
review,
we
focus
on
research
to
explore
differences
between
without
manifestations
biological
alterations,
elaborate
treatments
prognosis
anhedonia.
It
is
demonstrated
associated
adverse
outcomes
including
more
severe
episode
suicidality,
poor
MDD.
At
level,
seem
present
higher
levels
inflammatory
factors,
abnormal
metabolic
function
hypermetabolism
BDNF.
brain
imaging
studies,
there
are
some
structural
and/
or
functional
changes
multiple
regions
subcortical
cortical
areas,
well
limbic
system
Meanwhile,
preliminary
findings
also
indicated
associations
intestinal
flora
imbalance
Moreover,
evidence
benefit
selective
serotonin
reuptake
inhibitors
seemed
limited
anhedonia,
other
psychotherapy,
physical
therapy
probiotic
interventions
remained
be
explored
but
interesting
potential.
Therefore,
increased
awareness
anhedonic
unique
features
would
improved
early
diagnosis
therapeutic
effects
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 4, 2025
Anhedonia,
characterized
by
diminished
motivation
and
pleasure
sensitivity,
is
increasingly
recognized
as
prevalent
among
patients
with
chronic
pain.
Deep
Endometriosis
(DE),
the
most
severe
endophenotype
of
disease,
commonly
presented
pelvic
This
cross-sectional
study
reports,
for
first
time,
prevalence
anhedonia
in
a
sample
comprised
212
premenopausal
women
suspected
DE
referred
to
tertiary
hospital.
Our
findings
show
that
27,8%
[95%
CI
22.1,
26.5]
experience
abnormal
hedonic
tone.
Severity
pain-related
symptoms
significantly
correlated
anhedonia,
consistent
previous
findings.
Chronic
pain
emerged
significant
predictor
(OR
1.5,
95%
1.0–1.22,
p
<
0.05)
odds
increasing
2.28
1.12,
4.23]
when
was
severe.
The
affected
areas
were
interests,
social
interaction
food
pleasure.
present
results
are
representative
under
multimodal
treatment,
limiting
generalizability.
Overall,
our
highlights
impact
on
functioning
DE.
Therapeutic
approaches
targeting
capacity
crucial
restoring
health
well-being.
Translational Psychiatry,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 21, 2025
Anhedonia,
as
one
of
the
core
symptoms
major
depressive
disorder
(MDD),
has
been
regarded
a
potential
endophenotype
disease.
Multiple
studies
have
evaluated
mechanisms
anhedonia
in
MDD,
and
found
that
MDD
patients
with
showed
different
functions
clinical
features.
In
this
review,
we
focus
on
research
to
explore
differences
between
without
manifestations
biological
alterations,
elaborate
treatments
prognosis
anhedonia.
It
is
demonstrated
associated
adverse
outcomes
including
more
severe
episode
suicidality,
poor
MDD.
At
level,
seem
present
higher
levels
inflammatory
factors,
abnormal
metabolic
function
hypermetabolism
BDNF.
brain
imaging
studies,
there
are
some
structural
and/
or
functional
changes
multiple
regions
subcortical
cortical
areas,
well
limbic
system
Meanwhile,
preliminary
findings
also
indicated
associations
intestinal
flora
imbalance
Moreover,
evidence
benefit
selective
serotonin
reuptake
inhibitors
seemed
limited
anhedonia,
other
psychotherapy,
physical
therapy
probiotic
interventions
remained
be
explored
but
interesting
potential.
Therefore,
increased
awareness
anhedonic
unique
features
would
improved
early
diagnosis
therapeutic
effects
