The global prevalence of complete hearing loss in 204 countries and territories from 1992 to 2021: a systematic analysis for the global burden of disease study 2021
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 9, 2025
Background
Complete
hearing
loss,
especially
the
age-related
type,
poses
a
significant
public
health
challenge
globally.
This
study
aims
to
assess
global
burden
on
prevalence
of
complete
loss
from
1992
2021
and
forecast
trends
up
2036.
Methods
Using
data
Global
Burden
Disease
(GBD)
Study
2021,
we
assessed
across
204
countries
territories.
We
analyzed
temporal
in
ASPR
using
Joinpoint
regression,
evaluated
contributions
age,
period,
cohort
effects
through
Age-Period-Cohort
modeling,
performed
decomposition
analysis
determine
impact
demographic
epidemiological
changes
trends.
Predictions
future
were
made
Bayesian
(BAPC)
Autoregressive
Integrated
Moving
Average
(ARIMA)
models.
Results
By
had
reached
9.9
million
cases,
with
declining
134.35
117.79
per
100,000.
The
overall
Estimated
Annual
Percentage
Change
(EAPC)
was−0.45.
most
reductions
observed
low-SDI
regions,
particularly
Sub-Saharan
Africa
(EAPC:
−0.74).
In
contrast,
high-SDI
including
North
America
Western
Europe,
showed
more
modest
declines
−0.18).
Notably,
East
Asia
exhibited
62.3%
increase
prevalence,
high-income
Pacific
showing
highest
relative
rise
at
83.97%.
Age-related
remained
dominant
cause,
among
individuals
aged
60
above.
Males
affected
than
females.
Population
aging
growth
major
drivers
increased
while
population
was
primary
factor
areas.
Conclusion
remains
high
populations
within
despite
ASPR.
Significant
regional
disparities
remain,
highlighting
need
for
targeted
interventions
improve
access
care
affordable
technologies
regions.
Язык: Английский
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet andPharmacological Reviews
Pharmacological Reviews,
Год журнала:
2024,
Номер
76(6), С. 972 - 977
Опубликована: Окт. 16, 2024
This
special
issue
emerged
from
an
informal
discussion
at
editorial
board
meeting
during
2023,
where
the
75th
anniversaries
of
Pharmacological
Reviews
and
Department
Physiology
Pharmacology
Karolinska
Institutet,
Stockholm,
Sweden
were
coincidentally
discussed.
The
idea
for
Язык: Английский
The Rise of Cochlear Gene Therapy
Molecular Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Recent
evidence
provides
strong
support
for
the
safe
and
effective
use
of
gene
therapy
in
humans
with
hearing
loss.
By
means
a
single
local
injection
set
adeno-associated
virus
(AAV)
vectors,
was
partially
restored
several
children
neurosensory
nonsyndromic
autosomal
recessive
deafness
9
(DFNB9),
harboring
variants
OTOF
gene.
Current
research
focuses
on
refining
endoscopic
transmastoid
procedures
to
reduce
risks
side
effects,
as
emerging
suggests
bidirectional
fluid
exchanges
between
ear
brain.
Moreover,
editing
approaches
novel
AAV
capsids
are
successfully
tested
animal
models
will
likely
lead
enhanced
targeting
cochlea.
Here,
we
cover
recent
advances
cochlear
therapy,
provide
an
overview
translational
potential
these
new
existing
future
clinical
trials,
highlight
implications
that
remain
be
determined
their
application
humans.Graphical
abstract
Язык: Английский