Chemical Reviews,
Год журнала:
2021,
Номер
121(4), С. 2109 - 2146
Опубликована: Янв. 18, 2021
Biocompatible
conductors
are
important
components
for
soft
and
stretchable
bioelectronics
digital
healthcare,
which
have
attracted
extensive
research
efforts.
Natural
biopolymers,
compared
to
other
polymers,
possess
unique
features
that
make
them
promising
building
blocks
biocompatible
conductors,
such
as
good
biocompatibility/biodegradability,
natural
abundance,
sustainability,
capability,
can
be
processed
into
various
functional
formats
with
tunable
material
properties
under
benign
conditions.
In
this
comprehensive
review,
we
focus
on
the
recent
advances
in
based
biopolymers
bioelectronics.
We
first
give
a
brief
introduction
of
conductive
polymers
summarize
development
representative
including
protein
(silk),
polypeptide
(gelatin),
polysaccharide
(alginate).
The
design
fabrication
strategies
these
outlined,
after
chemical
structure
presented.
Then
discuss
electronic
component-biopolymer
interface
bioelectronic-biological
tissue
(skin
internal
tissues)
interface,
highlight
techniques
bioelectronics,
introduce
examples
utilizing
biopolymer-based
on-skin
textile-based
wearable
electronics,
implantable
healthcare.
Finally,
present
concluding
remarks
challenges
prospects
designing
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Июнь 8, 2021
To
understand
the
underlying
mechanisms
of
progressive
neurophysiological
phenomena,
neural
interfaces
should
interact
bi-directionally
with
brain
circuits
over
extended
periods
time.
However,
such
remain
limited
by
foreign
body
response
that
stems
from
chemo-mechanical
mismatch
between
probes
and
tissues.
address
this
challenge,
we
developed
a
multifunctional
sensing
actuation
platform
consisting
multimaterial
fibers
intimately
integrated
within
soft
hydrogel
matrix
mimicking
tissue.
These
hybrid
devices
possess
adaptive
bending
stiffness
determined
hydration
states
matrix.
This
enables
their
direct
insertion
into
deep
regions,
while
minimizing
tissue
damage
associated
micromotion
after
implantation.
The
permit
electrophysiological,
optogenetic,
behavioral
studies
minimal
responses
tracking
stable
isolated
single
neuron
potentials
in
freely
moving
mice
6
months
following
Proceedings of the National Academy of Sciences,
Год журнала:
2017,
Номер
114(23), С. 5894 - 5899
Опубликована: Май 22, 2017
Significance
Seamless
integration
of
electrical
probes
within
neural
tissue
could
substantially
enhance
their
impact
and
open
up
new
opportunities
in
neuroscience
research
through
electronic
therapeutics.
This
paper
describes
systematic
studies
brain
behavior
following
implantation
a
design
for
that
can
be
precisely
targeted
to
specific
regions
by
syringe
injection
as
many
biological
species
have
an
ultraflexible
mesh
structure
similar
itself.
Studies
the
chronic
response
postimplantation
demonstrate
these
tissue-like
do
not
elicit
inflammation
or
scarring,
contrast
more
conventional
probes.
Moreover,
neurons
were
found
penetrate
probes’
structure,
thus
demonstrating
unprecedented
level
compatibility
with
circuitry.
Science,
Год журнала:
2020,
Номер
370(6521), С. 1191 - 1196
Опубликована: Дек. 4, 2020
Blindness
affects
40
million
people
across
the
world.
A
neuroprosthesis
could
one
day
restore
functional
vision
in
blind.
We
implanted
a
1024-channel
prosthesis
areas
V1
and
V4
of
visual
cortex
monkeys
used
electrical
stimulation
to
elicit
percepts
dots
light
(called
phosphenes)
on
hundreds
electrodes,
locations
which
matched
receptive
fields
stimulated
neurons.
Activity
area
predicted
phosphene
that
were
elicited
V1.
simultaneously
multiple
electrodes
impose
visible
patterns
composed
number
phosphenes.
The
immediately
recognized
them
as
simple
shapes,
motions,
or
letters.
These
results
demonstrate
potential
functional,
life-enhancing
Proceedings of the National Academy of Sciences,
Год журнала:
2018,
Номер
115(7)
Опубликована: Янв. 29, 2018
Capabilities
for
recording
neural
activity
in
behaving
mammals
have
greatly
expanded
our
understanding
of
brain
function.
Some
the
most
sophisticated
approaches
use
light
delivered
by
an
implanted
fiber-optic
cable
to
optically
excite
genetically
encoded
calcium
indicators
and
record
resulting
changes
fluorescence.
Physical
constraints
induced
cables
bulk,
size,
weight
associated
fixtures
complicate
studies
on
natural
behaviors,
including
social
interactions
movements
environments
that
include
obstacles,
housings,
other
complex
features.
Here,
we
introduce
a
wireless,
injectable
fluorescence
photometer
integrates
miniaturized
source
photodetector
flexible,
needle-shaped
polymer
support,
suitable
injection
into
deep
at
sites
interest.
The
ultrathin
geometry
compliant
mechanics
these
probes
allow
minimally
invasive
implantation
stable
chronic
operation.
In
vivo
freely
moving
animals
demonstrate
this
technology
allows
high-fidelity
brain,
with
measurement
characteristics
match
or
exceed
those
fiber
photometry
systems.
capabilities
optical
recordings
neuronal
dynamics
untethered,
potential
widespread
applications
neuroscience
research.
