Advanced Materials,
Год журнала:
2021,
Номер
33(26)
Опубликована: Май 25, 2021
Abstract
Flexible
and
stretchable
antennas
are
important
for
wireless
communication
using
wearable
implantable
devices
to
address
mechanical
mismatch
at
the
tissue–device
interface.
Emerging
technologies
of
liquid‐metal‐based
electronics
promising
approaches
improve
flexibility
stretchability
conventional
metal‐based
antennas.
However,
existing
methods
encapsulate
liquid
metals
require
monolithically
thick
(at
least
100
µm)
substrates,
resulting
limited
in
deformability
tissue‐adhesiveness.
To
overcome
this
limitation,
fabrication
microchannels
by
direct
ink
writing
on
a
7
µm‐thick
elastomeric
substrate
is
demonstrated,
obtain
metal
microfluidic
with
unprecedented
deformability.
The
fabricated
light‐emitting
device
powered
standard
near‐field‐communication
system
(13.56
MHz,
1
W)
retained
consistent
operation
under
deformations
including
stretching
(>200%
uniaxial
strain),
twisting
(180°
twist),
bending
(3.0
mm
radius
curvature)
while
maintaining
high
quality
factor
(
q
>
20).
Suture‐free
conformal
adhesion
polydopamine‐coated
ex
vivo
animal
tissues
also
demonstrated.
This
technology
offers
new
capability
design
biomedical
requiring
conformable
tissue‐device
integration
toward
minimally
invasive,
imperceptible
medical
treatments.
Advanced Materials,
Год журнала:
2021,
Номер
34(16)
Опубликована: Дек. 12, 2021
Abstract
Medical
robots
are
invaluable
players
in
non‐pharmaceutical
treatment
of
disabilities.
Particularly,
using
prosthetic
and
rehabilitation
devices
with
human–machine
interfaces
can
greatly
improve
the
quality
life
for
impaired
patients.
In
recent
years,
flexible
electronic
soft
robotics
have
attracted
tremendous
attention
this
field
due
to
their
high
biocompatibility,
functionality,
conformability,
low‐cost.
Flexible
on
will
make
a
promising
alternative
conventional
rigid
devices,
which
potentially
revolutionize
paradigm
future
direction
medical
terms
feedback
user
experience.
review,
fundamental
components
materials,
structures,
mechanisms
human‐machine
summarized
by
renowned
applications
five
primary
areas:
physical
chemical
sensing,
physiological
recording,
information
processing
communication,
robotic
actuation,
stimulation.
This
review
further
concludes
discussing
outlook
current
challenges
these
technologies
as
interface
robotics.
Personalized
biomedical
devices
have
enormous
potential
to
solve
clinical
challenges
in
urgent
medical
situations.
Despite
this
potential,
a
device
for
situ
treatment
of
fatal
seizures
using
pharmaceutical
methods
has
not
been
developed
yet.
Here,
we
present
novel
system
neurological
emergencies,
such
as
status
epilepticus,
epileptic
condition
that
requires
immediate
treatment,
soft
implantable
drug
delivery
(SID).
The
SID
is
integrated
wirelessly
with
wearable
monitoring
electroencephalography
signals
and
triggering
subcutaneous
release
through
wireless
voltage
induction.
Because
the
integration,
bulky
rigid
components
sensors,
batteries,
electronic
circuits
can
be
moved
from
wearables,
thus,
mechanical
softness
miniaturization
are
achieved.
efficacy
prompt
could
demonstrated
animal
experiments
vivo,
which
brain
damages
were
reduced
survival
rates
increased.
Materials Today,
Год журнала:
2021,
Номер
51, С. 165 - 187
Опубликована: Окт. 12, 2021
Neuronal
microenvironment
imbalance
is
associated
with
successive
and
irreversible
pathophysiological
changes
insufficient
functional
restoration
after
peripheral
nerve
injury.
Conventional
neural-supporting
scaffolds
result
in
unsatisfactory
curative
effects
due
to
lack
of
biomimetic
nanotechnology
designs
biochemical
or
physicochemical
modifications.
Consequently,
they
fail
rational
facile
remodeling
the
imbalanced
growth
microenvironment,
cannot
recover
neural
structure
function.
In
recent
years,
increasing
knowledge
neuronal
injury-associated
a
number
novel
strategies
are
applied
enhancing
natures
nanomaterial-based
for
tissue
engineering.
These
nanoscale
can
trigger
factor
secretion
aggregation
through
surface
modification,
regulate
ATP
synthesis
hydrolysis,
switch
between
oxidation
reduction
states,
activate
ion
channels
stimulate
electrical
signals
under
certain
biophysical
cues.
determine
cell
fate
by
modulating
their
viability,
development
cycles
during
regeneration
process.
this
review,
we
systematically
summarize
studies
on
scaffold
design
nanomaterials,
basic
topological,
physical
properties,
nanotechnology-based
balanced
nutritional
regarding
four
key
factors,
including
immune
response,
intraneural
vascularization,
bioenergetic
metabolism
bioelectrical
conduction
order
provide
ideas
inspiration
nanomedicine-based
therapy.
