Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Ноя. 19, 2021
Electrosynthesis
has
received
great
attention
among
researchers
in
both
academia
and
industry
as
an
ideal
technique
to
promote
single
electron
reduction
without
the
use
of
expensive
catalysts.
In
this
work,
we
report
electrochemical
Katritzky
salts
alkyl
radicals
by
sacrificing
easily
accessible
metal
anode.
This
catalyst
electrolyte
free
platform
broad
applicability
transfer
chemistry,
including
fluoroalkenylation,
alkynylation
thiolation.
The
deaminative
functionalization
is
facilitated
rapid
molecular
diffusion
across
microfluidic
channels,
demonstrating
practicality
that
outpaces
conventional
electrochemistry
setups.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Окт. 7, 2020
Abstract
Alkyl
carboxylic
acids
as
well
primary
amines
are
ubiquitous
in
all
facets
of
biological
science,
pharmaceutical
chemical
science
and
materials
science.
By
conversion
to
redox-active
esters
(RAE)
Katritzky’s
N
-alkylpyridinium
salts,
respectively,
alkyl
serve
ideal
starting
forge
new
connections.
In
this
work,
a
Mn-mediated
reductive
decarboxylative/deaminative
functionalization
activated
aliphatic
is
disclosed.
A
series
C-X
(X
=
S,
Se,
Te,
H,
P)
C-C
bonds
efficiently
constructed
under
simple
mild
reaction
conditions.
The
protocol
applicable
the
late-stage
modification
some
structurally
complex
natural
products
or
drugs.
Preliminary
mechanistic
studies
suggest
involvement
radicals
pathway.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(4), С. 1470 - 1510
Опубликована: Янв. 1, 2022
Recent
developments
in
the
use
of
boron,
silicon,
nitrogen
and
sulfur
derivatives
single-electron
transfer
reactions
for
generation
alkyl
radicals
are
described.
Photoredox
catalyzed,
electrochemistry
promoted
or
thermally-induced
oxidative
reductive
processes
discussed
highlighting
their
synthetic
scope
discussing
mechanistic
pathways.
Organometallics,
Год журнала:
2022,
Номер
41(6), С. 667 - 679
Опубликована: Март 4, 2022
The
formation
of
a
new
C–C
bond
at
sp3-hybridized
centers
is
highly
desirable,
as
it
opens
up
unique,
unexplored
chemical
space.
revolutionary
discoveries
in
this
field
meet
the
longstanding
challenge
forming
stereocontrolled
bonds
and
provide
rapid
access
to
C(sp3)-rich
drug
molecules.
improved
catalytic
systems
have
enabled
creative
design
challenging
transformations.
latest
advancements
nickel
catalysis
are
particularly
attractive
shown
excellent
performance
field.
progress
that
has
been
made
toward
C(sp3)–C(sp3)
(traditional
cross-electrophile
couplings)
past
decade
highlighted
review.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Ноя. 19, 2021
Electrosynthesis
has
received
great
attention
among
researchers
in
both
academia
and
industry
as
an
ideal
technique
to
promote
single
electron
reduction
without
the
use
of
expensive
catalysts.
In
this
work,
we
report
electrochemical
Katritzky
salts
alkyl
radicals
by
sacrificing
easily
accessible
metal
anode.
This
catalyst
electrolyte
free
platform
broad
applicability
transfer
chemistry,
including
fluoroalkenylation,
alkynylation
thiolation.
The
deaminative
functionalization
is
facilitated
rapid
molecular
diffusion
across
microfluidic
channels,
demonstrating
practicality
that
outpaces
conventional
electrochemistry
setups.
