Frontiers in Bioengineering and Biotechnology,
Год журнала:
2020,
Номер
8
Опубликована: Июль 30, 2020
The
number
of
methodologies
for
the
immobilization
enzymes
using
polymeric
supports
is
continuously
growing
due
to
developments
in
fields
biotechnology,
polymer
chemistry,
and
nanotechnology
last
years.
Despite
being
excellent
catalysts,
are
very
sensitive
molecules
can
undergo
denaturation
beyond
their
natural
environment.
For
overcoming
this
issue,
chemistry
offers
a
wealth
opportunities
successful
combination
with
versatile
or
synthetic
polymers.
fabrication
functional,
stable,
robust
biocatalytic
hybrid
materials
(nanoparticles,
capsules,
hydrogels,
films)
has
been
proven
advantageous
several
applications
such
as
biomedicine,
organic
synthesis,
biosensing,
bioremediation.
In
review,
supported
recent
examples
enzyme-protein
hybrids,
we
provide
an
overview
methods
used
combine
both
macromolecules,
well
future
directions
main
challenges
that
currently
tackled
field.
Chemical Reviews,
Год журнала:
2021,
Номер
121(3), С. 1077 - 1129
Опубликована: Янв. 13, 2021
Because
of
their
efficiency,
selectivity,
and
environmental
sustainability,
there
are
significant
opportunities
for
enzymes
in
chemical
synthesis
biotechnology.
However,
as
the
three-dimensional
active
structure
is
predominantly
maintained
by
weaker
noncovalent
interactions,
thermal,
pH,
stressors
can
modify
or
eliminate
activity.
Metal–organic
frameworks
(MOFs),
which
extended
porous
network
materials
assembled
a
bottom-up
building
block
approach
from
metal-based
nodes
organic
linkers,
be
used
to
afford
protection
enzymes.
The
self-assembled
structures
MOFs
encase
an
enzyme
process
called
encapsulation
when
MOF
synthesized
presence
biomolecule.
Alternatively,
infiltrated
into
mesoporous
surface
bound
via
covalent
processes.
Integration
this
way
affords
allows
maintain
activity
challenge
conditions
(e.g.,
denaturing
agents,
elevated
temperature,
non-native
solvents).
In
addition
forming
simple
enzyme/MOF
biocomposites,
other
introduced
composites
improve
recovery
facilitate
advanced
applications
sensing
fuel
cell
technology.
This
review
canvasses
encapsulation,
pore
infiltration,
adsorption
summarizes
strategies
form
multicomponent
composites.
Also,
given
that
biocomposites
straddle
chemistry
enzymology,
provides
assessment
characterization
methodologies
MOF-immobilized
identifies
some
key
parameters
development
field.
Advanced Materials,
Год журнала:
2021,
Номер
33(46)
Опубликована: Май 28, 2021
Abstract
Metal–organic
frameworks
(MOFs)
have
emerged
as
one
of
the
most
widely
investigated
materials
in
catalysis
mainly
due
to
their
excellent
component
tunability,
high
surface
area,
adjustable
pore
size,
and
uniform
active
sites.
However,
overwhelming
number
MOF
complex
structures
has
brought
difficulties
for
researchers
select
construct
suitable
MOF‐based
catalysts.
Herein,
a
programmable
design
strategy
is
presented
based
on
metal
ions/clusters,
organic
ligands,
modifiers,
functional
materials,
post‐treatment
modules,
which
can
be
used
components,
structures,
morphologies
catalysts
different
reactions.
By
establishing
corresponding
relationship
between
these
modules
functions,
accurately
efficiently
heterometallic
MOFs,
chiral
conductive
hierarchically
porous
defective
composites,
MOF‐derivative
Further,
this
approach
also
regulate
physical/chemical
microenvironments
pristine
heterogeneous
catalysis,
electrocatalysis,
photocatalysis.
Finally,
challenging
issues
opportunities
future
research
are
discussed.
Overall,
modular
concept
review
applied
potent
tool
exploring
structure–activity
relationships
accelerating
on‐demand
multicomponent
Coordination Chemistry Reviews,
Год журнала:
2020,
Номер
429, С. 213651 - 213651
Опубликована: Дек. 18, 2020
Metal–organic
frameworks
(MOFs)
combined
with
biomacromolecules,
viruses
and
cells
have
emerged
as
novel
biocomposites
for
application
to
drug
delivery,
biosensing,
biospecimen
preservation,
cell
virus
manipulation.
The
integration
of
biological
entities
into
MOF
matrices
generates
functional
characteristics
that
cannot
be
observed
in
the
separate
components,
such
enhanced
chemical
thermal
stability,
resistance
proteases,
MOF-conferred
selectivity,
controlled
release.
In
this
review,
we
will
discuss
these
properties
applications
obtained
by
encapsulation
(i)
proteins,
(ii)
carbohydrates,
(iii)
nucleic
acids,
(iv)
or
a
matrix.
Finally,
review
post
functionalization
MOF-based
carriers
lipids
potential
route
enhance
dispersion,
stability
fluids,
blood
circulation
time
delivery
systems.
Chemical Reviews,
Год журнала:
2023,
Номер
123(9), С. 5347 - 5420
Опубликована: Апрель 12, 2023
Enzymatic
catalysis
has
fueled
considerable
interest
from
chemists
due
to
its
high
efficiency
and
selectivity.
However,
the
structural
complexity
vulnerability
hamper
application
potentials
of
enzymes.
Driven
by
practical
demand
for
chemical
conversion,
there
is
a
long-sought
quest
bioinspired
catalysts
reproducing
even
surpassing
functions
natural
As
nanoporous
materials
with
surface
areas
crystallinity,
metal-organic
frameworks
(MOFs)
represent
an
exquisite
case
how
enzymes
their
active
sites
are
integrated
into
porous
solids,
affording
heterogeneous
superior
stability
customizable
structures.
In
this
review,
we
comprehensively
summarize
advances
MOFs
catalysis,
discuss
design
principle
various
MOF-based
catalysts,
such
as
MOF-enzyme
composites
embedded
sites,
explore
utility
these
in
different
reactions.
The
advantages
enzyme
mimetics
also
highlighted,
including
confinement,
templating
effects,
functionality,
comparison
homogeneous
supramolecular
catalysts.
A
perspective
provided
potential
solutions
addressing
current
challenges
MOF
catalysis.
Abstract
Nanoparticles
(NPs)
have
attracted
tremendous
interest
in
drug
delivery
the
past
decades.
Microfluidics
offers
a
promising
strategy
for
making
NPs
due
to
its
capability
precisely
controlling
NP
properties.
The
recent
success
of
mRNA
vaccines
using
microfluidics
represents
big
milestone
microfluidic
pharmaceutical
applications,
and
rapid
scaling
up
demonstrates
feasibility
industrial‐scale
manufacturing.
This
article
provides
critical
review
progress
delivery.
First,
synthesis
organic
focusing
on
typical
methods
their
applications
popular
clinically
relevant
NPs,
such
as
liposomes,
lipid
polymer
well
mechanisms
are
summarized.
Then,
several
representative
inorganic
(e.g.,
silica,
metal,
metal
oxide,
quantum
dots),
hybrid
is
discussed.
Lastly,
various
presented.
eScience,
Год журнала:
2023,
Номер
3(2), С. 100092 - 100092
Опубликована: Янв. 10, 2023
Micro/nano
metal–organic
frameworks
(MOFs)
have
attracted
significant
attention
in
recent
years
due
to
their
numerous
unique
properties,
with
many
synthetic
methods
and
strategies
being
reported
for
constructing
MOFs
specific
micro/nano
structures.
In
addition,
the
design
of
energy
storage
conversion
applications
study
structure–activity
relationship
also
become
research
hotspots.
Herein,
a
comprehensive
overview
progress
on
is
presented.
We
begin
brief
introduction
various
synthesis
controlling
morphology
MOFs.
Subsequently,
structure-dependent
properties
as
electrode
materials
or
catalysts
terms
batteries,
supercapacitors,
catalysis
are
discussed.
Finally,
remaining
challenges
future
perspectives
this
field
Overall,
review
expected
inspire
advanced
efficient
technologies.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(17)
Опубликована: Фев. 22, 2021
Abstract
The
electrochemical
nitrogen
reduction
reaction
(NRR),
a
contributor
for
producing
ammonia
under
mild
conditions
sustainably,
has
recently
attracted
global
research
attention.
Thus
far,
the
design
of
highly
efficient
electrocatalysts
to
enhance
NRR
efficiency
is
specific
focus
research.
Among
them,
defect
engineering
considered
significant
way
improve
electrocatalytic
by
regulating
electronic
state
and
providing
more
active
sites
that
can
give
better
physicochemical
properties.
Recently,
metal–organic
frameworks
(MOFs),
along
with
their
derivatives,
have
captured
immense
interest
in
reactions
owing
not
only
large
surface
area
high
porosity
but
also
ability
create
rich
defects
structures.
Hence,
they
provide
plenty
exposed
electron
transfer,
NN
cleavage,
N
2
adsorption
performance.
Herein,
concept,
situ
characterizations
techniques
defects,
most
common
ways
into
MOFs
been
summarized.
Furthermore,
recent
advances
MOF‐based
towards
recapitulated.
Ultimately,
major
challenges
outlook
are
proposed.
This
paper
anticipated
critical
guidelines
optimizing
electrocatalysts.
