A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances DOI Creative Commons
Hanna Antila, Iris Kwak, Ashley Choi

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(45)

Опубликована: Ноя. 4, 2022

In our daily life, we are exposed to uncontrollable and stressful events that disrupt sleep. However, the underlying neural mechanisms deteriorating quality of non-rapid eye movement sleep (NREMs) REM largely unknown. Here, show in mice acute psychosocial stress disrupts by increasing brief arousals (microarousals [MAs]), reducing spindles, impairing infraslow oscillations spindle band electroencephalogram during NREMs, while REMs. This poor was reflected an increased number calcium transients activity noradrenergic (NE) neurons locus coeruleus (LC) NREMs. Opto- chemogenetic LC-NE activation naïve is sufficient change microarchitecture similar stress. Conversely, chemogenetically inhibiting reduced MAs NREMs normalized their after Specifically projecting preoptic area hypothalamus (POA) decreased enhanced spindles REMs Optrode recordings revealed stimulating fibers POA indeed suppressed spiking activated inactivated MAs. Our findings reveal changes dynamics stress-regulatory negatively affect quality, partially through interaction with POA.

Язык: Английский

Locus coeruleus: a new look at the blue spot DOI
Gina R. Poe,

Stephen L. Foote,

O Eschenko

и другие.

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(11), С. 644 - 659

Опубликована: Сен. 17, 2020

Язык: Английский

Процитировано

539

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial DOI
Jesse Dawson, Charles Y. Liu, Gerard E. Francisco

и другие.

The Lancet, Год журнала: 2021, Номер 397(10284), С. 1545 - 1553

Опубликована: Апрель 1, 2021

Язык: Английский

Процитировано

316

Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture DOI Creative Commons

Dan J. Chandler,

Patricia Jensen, Jordan G. McCall

и другие.

Journal of Neuroscience, Год журнала: 2019, Номер 39(42), С. 8239 - 8249

Опубликована: Окт. 16, 2019

The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that prominent component of disparate theories brain function due to its broad noradrenergic projections throughout the CNS. As diffuse system, noradrenaline affects learning decision making, control sleep wakefulness, sensory salience including pain, physiology correlated forebrain activity (ensembles networks) hemodynamic responses. However, our understanding LC undergoing dramatic shift application state-of-the-art methods reveal many modules provide targeted neuromodulation. Here, we review evidence supporting modular based on multiple levels observation (developmental, genetic, molecular, anatomical, neurophysiological). We suggest concept as and, alongside it, role in diverse must be reconsidered.

Язык: Английский

Процитировано

192

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine DOI
Celia Kjærby, Mie Andersen, Natalie Hauglund

и другие.

Nature Neuroscience, Год журнала: 2022, Номер 25(8), С. 1059 - 1070

Опубликована: Июль 7, 2022

Язык: Английский

Процитировано

184

Transcutaneous Vagus Nerve Stimulation in Humans Induces Pupil Dilation and Attenuates Alpha Oscillations DOI Creative Commons
O. Sharon, Firas Fahoum, Yuval Nir

и другие.

Journal of Neuroscience, Год журнала: 2020, Номер 41(2), С. 320 - 330

Опубликована: Ноя. 19, 2020

Vagus nerve stimulation (VNS) is widely used to treat drug-resistant epilepsy and depression. While the precise mechanisms mediating its long-term therapeutic effects are not fully resolved, they likely involve locus coeruleus (LC) via nucleus of solitary tract, which receives afferent vagal inputs. In rats, VNS elevates LC firing forebrain noradrenaline levels, whereas lesions suppress efficacy. Noninvasive transcutaneous (tVNS) uses electrical that targets auricular branch vagus at cymba conchae ear. However, extent tVNS mimics remains unclear. Here, we investigated short-term in healthy human male volunteers ( n = 24), using high-density EEG pupillometry during visual fixation rest. We compared short (3.4 s) trials sham earlobe (far from branch) control for somatosensory stimulation. Although did differ subjective intensity ratings, led robust pupil dilation (peaking 4–5 s after trial onset) was significantly higher than following further quantified, parallel factor analysis, how modulates idle occipital alpha (8–13Hz) activity identified each participant. found greater attenuation oscillations by This demonstrates reliably induces pupillary markers arousal beyond stimulation, thus supporting hypothesis other arousal-promoting neuromodulatory signaling, invasive VNS. SIGNIFICANCE STATEMENT Current noninvasive brain techniques mostly confined modulating cortical activity, as typical with transcranial magnetic or direct/alternating current Transcutaneous has been proposed stimulate subcortical nuclei, though previous studies yielded inconsistent results. Here show pulses naive induced transient oscillations. These line established on coeruleus–noradrenaline support Therefore, can be a tool studying endogenous signaling affects cognition, including perception, attention, memory, decision-making; also developing novel clinical applications.

Язык: Английский

Процитировано

152

Noradrenergic circuit control of non-REM sleep substates DOI Creative Commons
Alejandro Osorio-Forero, Romain Cardis, Gil Vantomme

и другие.

Current Biology, Год журнала: 2021, Номер 31(22), С. 5009 - 5023.e7

Опубликована: Окт. 14, 2021

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-rapid-eye-movement (NREMS). However, sensory vigilance persists NREMS animals and humans, suggesting that wake promotion could remain functional. Here, we demonstrate consolidated mouse a brain state with recurrent fluctuations of the neurotransmitter noradrenaline on ∼50-s timescale thalamus. These occurred around mean levels greater than ones quiet wakefulness, while (NA) declined steeply REMS. They coincided clustering spindle rhythms forebrain heart-rate variations, both which are correlates arousability. We addressed origins these by using closed-loop optogenetic locus coeruleus (LC) activation or inhibition timed moments low high NREMS. suppress, lock, entrain sleep-spindle fore- hindbrain-projecting LC neurons show coordinated infraslow variations natural Noradrenergic modulation thalamic, but not cortical, circuits was required for involved NA release into primary reticular thalamic nuclei activated α1- β-adrenergic receptors cause slowly decaying membrane depolarizations. signaling constitutes vigilance-promoting mechanism renders mammalian disruption close-to-minute through sustaining thalamocortical autonomic arousability.Video abstracthttps://www.cell.com/cms/asset/ab9ec3b8-a3f1-470e-8a9c-a2d6ebebc742/mmc3.mp4Loading ...(mp4, 35.34 MB) Download video

Язык: Английский

Процитировано

141

Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets DOI Creative Commons
Vincent Breton‐Provencher, Gabrielle T. Drummond, Mriganka Sur

и другие.

Frontiers in Neural Circuits, Год журнала: 2021, Номер 15

Опубликована: Июнь 7, 2021

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of neuromodulator norepinephrine (NE) in brain. LC receives input from widespread brain regions, and projects throughout forebrain, brainstem, cerebellum, spinal cord. neurons release NE to control arousal, but also context variety sensory-motor behavioral functions. Despite its brain-wide effects, much about role LC-NE behavior circuits controlling activity unknown. New evidence suggests that modular input-output organization could enable transient, task-specific modulation distinct regions. Future work must further assess whether this spatial modularity coincides with functional differences subpopulations acting at specific times, how such spatiotemporal specificity might influence learned behaviors. Here, we summarize state field present new ideas on

Язык: Английский

Процитировано

117

Noradrenergic modulation of rhythmic neural activity shapes selective attention DOI
Martin J. Dahl, Mara Mather, Markus Werkle‐Bergner

и другие.

Trends in Cognitive Sciences, Год журнала: 2021, Номер 26(1), С. 38 - 52

Опубликована: Ноя. 16, 2021

Язык: Английский

Процитировано

107

The Neural Circuits Underlying General Anesthesia and Sleep DOI Open Access
Olivia A. Moody, Edlyn R. Zhang, Kathleen F. Vincent

и другие.

Anesthesia & Analgesia, Год журнала: 2021, Номер 132(5), С. 1254 - 1264

Опубликована: Апрель 14, 2021

General anesthesia is characterized by loss of consciousness, amnesia, analgesia, and immobility. Important molecular targets general anesthetics have been identified, but the neural circuits underlying discrete end points remain incompletely understood. natural sleep share common feature reversible unconsciousness, recent developments in neuroscience enabled elegant studies that investigate brain nuclei this important point. A approach to measure cortical activity across electroencephalogram (EEG), which can reflect local neuronal as well connectivity among regions. The EEG oscillations observed during depend greatly on anesthetic agent dosing, only some resemble those sleep. For example, dexmedetomidine sedation are similar stage 2 nonrapid eye movement (NREM) sleep, high doses propofol ether produce burst suppression, a pattern never Sleep primarily driven withdrawal subcortical excitation cortex, directly act at both targets. While appear activate specific sleep-active regions induce not all play significant role anesthesia. Anesthetics also inhibit neurons, it likely each class drugs produces distinct combination effects lead unconsciousness. Conversely, arousal promote wakefulness involved emergence activating them accelerate recovery consciousness. Modern techniques enable manipulation led new insights into circuitry In coming years, we will continue better understand mechanisms generate these states

Язык: Английский

Процитировано

106

Spatiotemporal dynamics of noradrenaline during learned behaviour DOI
Vincent Breton‐Provencher, Gabrielle T. Drummond, Jiesi Feng

и другие.

Nature, Год журнала: 2022, Номер 606(7915), С. 732 - 738

Опубликована: Июнь 1, 2022

Язык: Английский

Процитировано

98