Neuro-orchestration of sleep and wakefulness

Nature Neuroscience, Год журнала: 2022, Номер 26(2), С. 196 - 212

Опубликована: Дек. 29, 2022

Язык: Английский

---

Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep

Nature Neuroscience, Год журнала: 2022, Номер 25(7), С. 935 - 943

Опубликована: Июль 1, 2022

Abstract During sleep, sensory stimuli rarely trigger a behavioral response or conscious perception. However, it remains unclear whether sleep inhibits specific aspects of processing, such as feedforward feedback signaling. Here, we presented auditory (for example, click-trains, words, music) during wakefulness and in patients with epilepsy, while recording neuronal spiking, microwire local field potentials, intracranial electroencephalogram polysomnography. Auditory induced robust selective spiking high-gamma (80–200 Hz) power responses across the lateral temporal lobe both non-rapid eye movement (NREM) rapid (REM) sleep. Sleep only moderately attenuated magnitudes, mainly affecting late beyond early cortex entrainment to click-trains NREM By contrast, auditory-induced alpha–beta (10–30 desynchronization (that is, decreased power), prevalent wakefulness, was strongly reduced Thus, extensive persist whereas decrease, likely reflecting neural processes, is deficient. More broadly, our findings suggest that signaling key processing.

Язык: Английский

---

When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 5028 - 5028

Опубликована: Апрель 30, 2022

For decades, numerous seminal studies have built our understanding of the locus coeruleus (LC), vertebrate brain’s principal noradrenergic system. Containing a numerically small but broadly efferent cell population, LC provides brain-wide modulation that optimizes network function in context attentive and flexible interaction with sensory environment. This review turns attention to LC’s roles during sleep. We show these go beyond down-scaled versions ones wakefulness. Novel dynamic assessments noradrenaline signaling activity uncover rich diversity patterns establish as an integral portion sleep regulation function. The could be involved beneficial functions for sleeping brain, even minute alterations its functionality may prove quintessential disorders.

Язык: Английский

---

Distinct ensembles in the noradrenergic locus coeruleus are associated with diverse cortical states

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(18)

Опубликована: Апрель 29, 2022

Significance Brainstem locus coeruleus (LC) noradrenergic neurons produce an arousal-related state characterized by a broadband increase in high-frequency oscillations. This perspective was built upon electrical or optogenetic stimulation that artificially activates LC synchronously. has led to the conceptual model activation is associated with single cortical state. Here, we show natural, spontaneously occurring single-unit activity consists of ensembles largely nonoverlapping dynamics. Spontaneous activations different are states. Our results suggest role controlling type arousal oversimplification. Instead, may control diverse multitude

Язык: Английский

---

A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(45)

Опубликована: Ноя. 4, 2022

In our daily life, we are exposed to uncontrollable and stressful events that disrupt sleep. However, the underlying neural mechanisms deteriorating quality of non-rapid eye movement sleep (NREMs) REM largely unknown. Here, show in mice acute psychosocial stress disrupts by increasing brief arousals (microarousals [MAs]), reducing spindles, impairing infraslow oscillations spindle band electroencephalogram during NREMs, while REMs. This poor was reflected an increased number calcium transients activity noradrenergic (NE) neurons locus coeruleus (LC) NREMs. Opto- chemogenetic LC-NE activation naïve is sufficient change microarchitecture similar stress. Conversely, chemogenetically inhibiting reduced MAs NREMs normalized their after Specifically projecting preoptic area hypothalamus (POA) decreased enhanced spindles REMs Optrode recordings revealed stimulating fibers POA indeed suppressed spiking activated inactivated MAs. Our findings reveal changes dynamics stress-regulatory negatively affect quality, partially through interaction with POA.

Язык: Английский

---