Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(45)
Опубликована: Ноя. 4, 2022
In
our
daily
life,
we
are
exposed
to
uncontrollable
and
stressful
events
that
disrupt
sleep.
However,
the
underlying
neural
mechanisms
deteriorating
quality
of
non-rapid
eye
movement
sleep
(NREMs)
REM
largely
unknown.
Here,
show
in
mice
acute
psychosocial
stress
disrupts
by
increasing
brief
arousals
(microarousals
[MAs]),
reducing
spindles,
impairing
infraslow
oscillations
spindle
band
electroencephalogram
during
NREMs,
while
REMs.
This
poor
was
reflected
an
increased
number
calcium
transients
activity
noradrenergic
(NE)
neurons
locus
coeruleus
(LC)
NREMs.
Opto-
chemogenetic
LC-NE
activation
naïve
is
sufficient
change
microarchitecture
similar
stress.
Conversely,
chemogenetically
inhibiting
reduced
MAs
NREMs
normalized
their
after
Specifically
projecting
preoptic
area
hypothalamus
(POA)
decreased
enhanced
spindles
REMs
Optrode
recordings
revealed
stimulating
fibers
POA
indeed
suppressed
spiking
activated
inactivated
MAs.
Our
findings
reveal
changes
dynamics
stress-regulatory
negatively
affect
quality,
partially
through
interaction
with
POA.
Nature Neuroscience,
Год журнала:
2022,
Номер
25(7), С. 935 - 943
Опубликована: Июль 1, 2022
Abstract
During
sleep,
sensory
stimuli
rarely
trigger
a
behavioral
response
or
conscious
perception.
However,
it
remains
unclear
whether
sleep
inhibits
specific
aspects
of
processing,
such
as
feedforward
feedback
signaling.
Here,
we
presented
auditory
(for
example,
click-trains,
words,
music)
during
wakefulness
and
in
patients
with
epilepsy,
while
recording
neuronal
spiking,
microwire
local
field
potentials,
intracranial
electroencephalogram
polysomnography.
Auditory
induced
robust
selective
spiking
high-gamma
(80–200
Hz)
power
responses
across
the
lateral
temporal
lobe
both
non-rapid
eye
movement
(NREM)
rapid
(REM)
sleep.
Sleep
only
moderately
attenuated
magnitudes,
mainly
affecting
late
beyond
early
cortex
entrainment
to
click-trains
NREM
By
contrast,
auditory-induced
alpha–beta
(10–30
desynchronization
(that
is,
decreased
power),
prevalent
wakefulness,
was
strongly
reduced
Thus,
extensive
persist
whereas
decrease,
likely
reflecting
neural
processes,
is
deficient.
More
broadly,
our
findings
suggest
that
signaling
key
processing.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(9), С. 5028 - 5028
Опубликована: Апрель 30, 2022
For
decades,
numerous
seminal
studies
have
built
our
understanding
of
the
locus
coeruleus
(LC),
vertebrate
brain’s
principal
noradrenergic
system.
Containing
a
numerically
small
but
broadly
efferent
cell
population,
LC
provides
brain-wide
modulation
that
optimizes
network
function
in
context
attentive
and
flexible
interaction
with
sensory
environment.
This
review
turns
attention
to
LC’s
roles
during
sleep.
We
show
these
go
beyond
down-scaled
versions
ones
wakefulness.
Novel
dynamic
assessments
noradrenaline
signaling
activity
uncover
rich
diversity
patterns
establish
as
an
integral
portion
sleep
regulation
function.
The
could
be
involved
beneficial
functions
for
sleeping
brain,
even
minute
alterations
its
functionality
may
prove
quintessential
disorders.
Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(18)
Опубликована: Апрель 29, 2022
Significance
Brainstem
locus
coeruleus
(LC)
noradrenergic
neurons
produce
an
arousal-related
state
characterized
by
a
broadband
increase
in
high-frequency
oscillations.
This
perspective
was
built
upon
electrical
or
optogenetic
stimulation
that
artificially
activates
LC
synchronously.
has
led
to
the
conceptual
model
activation
is
associated
with
single
cortical
state.
Here,
we
show
natural,
spontaneously
occurring
single-unit
activity
consists
of
ensembles
largely
nonoverlapping
dynamics.
Spontaneous
activations
different
are
states.
Our
results
suggest
role
controlling
type
arousal
oversimplification.
Instead,
may
control
diverse
multitude
Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(45)
Опубликована: Ноя. 4, 2022
In
our
daily
life,
we
are
exposed
to
uncontrollable
and
stressful
events
that
disrupt
sleep.
However,
the
underlying
neural
mechanisms
deteriorating
quality
of
non-rapid
eye
movement
sleep
(NREMs)
REM
largely
unknown.
Here,
show
in
mice
acute
psychosocial
stress
disrupts
by
increasing
brief
arousals
(microarousals
[MAs]),
reducing
spindles,
impairing
infraslow
oscillations
spindle
band
electroencephalogram
during
NREMs,
while
REMs.
This
poor
was
reflected
an
increased
number
calcium
transients
activity
noradrenergic
(NE)
neurons
locus
coeruleus
(LC)
NREMs.
Opto-
chemogenetic
LC-NE
activation
naïve
is
sufficient
change
microarchitecture
similar
stress.
Conversely,
chemogenetically
inhibiting
reduced
MAs
NREMs
normalized
their
after
Specifically
projecting
preoptic
area
hypothalamus
(POA)
decreased
enhanced
spindles
REMs
Optrode
recordings
revealed
stimulating
fibers
POA
indeed
suppressed
spiking
activated
inactivated
MAs.
Our
findings
reveal
changes
dynamics
stress-regulatory
negatively
affect
quality,
partially
through
interaction
with
POA.