Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(45)
Опубликована: Сен. 22, 2023
Abstract
A
library
of
phosphoramidite
monomers
containing
a
main‐chain
cleavable
alkoxyamine
and
side‐chain
substituent
variable
molar
mass
(i.e.
tag)
was
prepared
in
this
work.
These
can
be
used
automated
solid‐phase
chemistry
therefore
incorporated
periodically
as
spacers
inside
digitally‐encoded
poly(phosphodiester)
chains.
Consequently,
the
formed
polymers
contain
tagged
sites
that
guide
their
fragmentation
spectrometry
sequencing
enhance
digital
readability.
The
were
all
via
seven
steps
synthetic
procedure.
They
afterwards
tested
for
synthesis
model
polymers.
Uniform
obtained
major
species
cases,
even
though
some
minor
defects
sometimes
detected.
Furthermore,
decoded
pseudo‐MS
3
conditions,
thus
confirming
reliability
versatility
library.
Macromolecules,
Год журнала:
2023,
Номер
56(24), С. 9915 - 9938
Опубликована: Дек. 13, 2023
Polymer
brushes
have
been
theoretically
described,
their
behavior
under
diverse
conditions
has
modeled,
and
preparation
via
surface-initiated
polymerizations
(SIPs)
progressively
refined.
However,
despite
three
decades
of
research
endeavors
by
chemists
materials
scientists,
an
array
challenges
questions
characterizing
the
synthesis,
characterization,
understating
polymer
remains
motivates
this
Perspective.
How
do
main
structural
parameters
link
to
unique
properties?
Can
we
synthesize
multifunctional
in
a
more
practical
scalable
manner?
successfully
overcome
intrinsic
that
enable
comprehensive
characterization?
While
being
closer
than
ever
translation
into
technologically
relevant
materials,
tried
answer
these
simultaneously
outlining
status
subfield
science
evolving
perspectives
synthesis
characterization.
Hybrid
polyionic
complexes
(HPICs)
are
colloidal
structures
with
a
charged
core
rich
in
metal
ions
and
neutral
hydrophilic
corona.
Their
properties,
whether
as
reservoirs
or
catalysts,
depend
on
the
accessibility
environment
of
ions.
This
study
demonstrates
that
modifying
coordination
sphere
these
can
tune
properties
HPICs
by
altering
composition
complexing
block
varying
formulation
conditions.
Hence,
double
copolymers
were
synthesized
using
RAFT
polymerization,
polyethylene
glycol
different
ratios
acrylic
acid
(AA)
vinylphosphonic
(VPA)
functional
further
complexed
Fe(III)
The
resulting
iron-based
higher
VPA
content
more
stable
at
low
pH
due
to
stronger
VPA-iron
interactions,
but
their
catalytic
efficiency
photo-Fenton
process
decreased
pH.
In
nanoparticle
synthesis,
polymers
produced
smaller,
less-defined
Prussian
blue
nanoparticles,
while
50/50
AA/VPA
ratio
resulted
uniform
nanoparticles
optimal
reactivity.
Multivariate
analysis
revealed
not
only
also
local
structural
organization
impacts
HPIC
influenced
changes
structure
(e.g.,
statistical,
block)
Progress in Polymer Science,
Год журнала:
2023,
Номер
138, С. 101648 - 101648
Опубликована: Янв. 14, 2023
We
survey
progress
in
the
development
of
processes
for
radical-promoted
single-unit
monomer
insertion
(SUMI)
or
reversible
deactivation
radical
addition
(RDRA),
focussing
on
aminoxyl-
[nitroxide-]
mediated
SUMI
(NM-SUMI),
reversible-addition-fragmentation
chain
transfer-SUMI
(RAFT-SUMI)
and
atom-transfer
(ATRA).
Radical-promoted
thiol-ene
are
also
briefly
discussed.
detail
strategies
achieving
selectivity
with
respect
to
single
unit
vs
oligomerization
look
critically
at
towards
discrete
oligomer
synthesis
by
consecutive
reactions.
examine
use
install
α-,
ω-
mid-chain-functionality
RDRP-synthesized
polymers.
Finally,
we
prospects
using
sequence-defined
polymers
where
placement
is
precisely
defined
level
individual
units
polymer
chain.
Progress in Polymer Science,
Год журнала:
2023,
Номер
147, С. 101754 - 101754
Опубликована: Окт. 20, 2023
A
fundamental
endeavour
in
macromolecular
science
is
the
control
of
molecular-level
complexity,
including
molecular
weight
distribution,
end
groups
and
architecture.
Since
discovery
that
native
biomacromolecules
can
have
a
specific
sequence
translating
biological
function,
controlling
individual
monomer
has
become
ultimate
expression
complexity.
Replicating
this
remarkable
structural
precision
abiological
macromolecules
emerged
as
defining
goal
challenge
within
polymer
science.
In
Review,
we
survey
developments
synthetic
methods,
characterisation
techniques,
simulation
workflows
applications
relevant
to
goal.
We
also
address
broader
question
what
extent
such
complexity
significant
macromolecules.
Specifically,
will
focus
on
Review
because
its
importance
connecting
synthesis
with
applications.
JACS Au,
Год журнала:
2025,
Номер
5(3), С. 1232 - 1242
Опубликована: Фев. 19, 2025
The
field
of
molecular
information
storage
has
recently
expanded
to
include
abiotic
sequence-defined
polymers.
While
robust
methods
have
been
developed,
there
is
a
current
bottleneck
in
the
throughput
this
work
as
density
increased.
Herein,
we
introduce
an
automated
workflow
which
commercial
peptide
synthesizer
composed
single
XYZ
liquid-handling
robot
was
adapted
both
synthesize
and
sequence
oligourethanes.
Our
sequencing
method
improved
cut
down
number
samples
required
for
each
oligomer
from
13
one.
Additionally,
use
desorption
electrospray
ionization
mass
spectrometry
our
analysis
sequencing,
allowed
simplified
increased
speed
data
acquisition.
Finally,
created
Python
script
that
able
reconstruct
MS
fashion.
We
demonstrate
new
by
encoding
decoding
quote
late
Maya
Angelou:
"When
you
learn,
teach,
when
get,
give".
