Multiparametric quantitative MRI uncovers putamen microstructural changes in Parkinson's Disease DOI Creative Commons
Elior Drori, Lee S. Cohen, David Arkadir

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 31, 2024

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder dominated by motor and non-motor dysfunction. Despite extensive research, the in vivo characterization of PD-related microstructural brain changes remains an ongoing challenge, limiting advancements diagnostic therapeutic strategies. The putamen, critical structure within basal ganglia, plays key role regulating movement profoundly affected early neurodegeneration. In this study, we collected multiparametric quantitative MRI (qMRI) data PD patients healthy controls, to investigate alterations putamen PD. We utilized gradient analysis technique analyze spatial variations various qMRI parameters, including relaxation rates (R1, R2, R2*), water fraction (WF), susceptibility, magnetization transfer saturation (MTsat), diffusion metrics (MD, FA). Our findings reveal significant gradients interhemispheric asymmetries these biophysical properties along anterior-posterior axis putamen. Notably, exhibited increased altered transverse rate R2*, particularly posterior correlated with symptom laterality. These suggest underlying tissue atrophy or neuroinflammatory processes associated study underscores importance as focal point for pathology highlights potential localized detecting subtle yet clinically changes. new dataset provides valuable insights into pathology, potentially aiding development more precise tools targeted therapies.

Язык: Английский

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential DOI

Xv-shen Ding,

Li Gao, Han Zheng

и другие.

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102077 - 102077

Опубликована: Сен. 24, 2023

Язык: Английский

Процитировано

79
Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions DOI Creative Commons
Angeliki Zarkali, George E. Thomas, Henrik Zetterberg

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 5, 2024

Abstract A major challenge in Parkinson’s disease is the variability symptoms and rates of progression, underpinned by heterogeneity pathological processes. Biomarkers are urgently needed for accurate diagnosis, patient stratification, monitoring progression precise treatment. These were previously lacking, but recently, novel imaging fluid biomarkers have been developed. Here, we consider new approaches showing sensitivity to brain tissue composition, examine specificity processes, including seed amplification assays extracellular vesicles. We reflect on these context biological staging systems, emerging techniques currently development.

Язык: Английский

Процитировано

17
Transcriptomic profiles link corticostriatal microarchitecture to genetics of neurodevelopment and neuropsychiatric risks DOI Creative Commons
Sheng Hu, Yanming Wang, Xiaoxiao Wang

и другие.

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 11, 2025

Many studies on macroscale organization have focused only the cerebral cortex or striatum, leaving a large gap in microstructural gradient of corticostriatal covariance. Here, we partitioned striatum into seven distinct parcels and computed covariance between each parcel using T1-weighted/T2-weighted mapping. We found that exhibited along anterior-posterior axis striatum. The patterns are linked to geodesic distance cell type-specific gene expression profiles, revealing gradually attenuated relationship Linking profile showed transcriptional variations genes different anterior posterior suggested more enriched psychiatric disorders. Moreover, at genetic level, microarchitecture spatiotemporal trait during neurodevelopment. Finally, identified neural circuits from limbic medial frontal contributes common neuropsychiatric Collectively, our findings reveal spatially covarying specializations with covariance, highlighting mechanisms underlying neurodevelopmental may be involved

Язык: Английский

Процитировано

1
Visualizing alpha‐synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo DOI Creative Commons

Nadja Straumann,

Benjamin F. Combes,

Xosé Luis Dean Ben

и другие.

Brain Pathology, Год журнала: 2024, Номер 34(6)

Опубликована: Июль 9, 2024

Abstract Abnormal alpha‐synuclein (αSyn) and iron accumulation in the brain play an important role Parkinson's disease (PD). Herein, we aim to visualize αSyn inclusions deposition brains of M83 (A53T) mouse models PD vivo. The fluorescent pyrimidoindole derivative THK‐565 probe was characterized by means recombinant fibrils from 10‐ 11‐month‐old mice. Concurrent wide‐field fluorescence volumetric multispectral optoacoustic tomography (vMSOT) imaging were subsequently performed Structural susceptibility weighted (SWI) magnetic resonance (MRI) at 9.4 T as well scanning transmission x‐ray microscopy (STXM) characterize deposits perfused brains. Immunofluorescence Prussian blue staining further on slices validate detection deposition. showed increased upon binding post‐mortem patients with Administration mice higher cerebral retention 20 40 min post‐intravenous injection compared nontransgenic littermate mice, congruence vMSOT findings. SWI/phase images indicated presumably Fe 3+ form, evinced STXM results. In conclusion, demonstrated vivo mapping noninvasive epifluorescence validated results targeting label SWI/STXM identification ex

Язык: Английский

Процитировано

7
Nigrostriatal iron accumulation in the progression of Parkinson’s disease DOI Creative Commons
Miguel López‐Aguirre, Tiziano Balzano, Mariana H.G. Monje

и другие.

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 11, 2025

Iron deposition in the nigrostriatal system plays a pivotal role Parkinson's disease (PD) onset and progression. This study explored time course of iron accumulation 54 PD patients at early to moderately advanced stages 20 age-matched healthy controls. Using multi-echo T2*-MRI R2* relaxometry, content was assessed substantia nigra pars compacta (SNpc) striatum. In vivo findings were contrasted with histological analyses progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism model involving six non-human primates (NHPs) two controls using Perls' Prussian blue staining. Complementarily, dopaminergic degeneration quantified by 6-[18F]-fluoro-L-dopa PET humans TH immunohistochemistry NHPs. Results showed SNpc correlating striatal denervation neuronal loss. Striatal followed V-shaped progression, decreasing initially increasing later. may serve as marker neurodegeneration PD, while decreased indicate pathological susceptibility

Язык: Английский

Процитировано

1
Disruptions of Hierarchical Cortical Organization in Early Psychosis and Schizophrenia DOI Creative Commons
Alexander Holmes, Priscila T. Levi, Yu‐Chi Chen

и другие.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2023, Номер 8(12), С. 1240 - 1250

Опубликована: Сен. 6, 2023

The cerebral cortex is organized hierarchically along an axis that spans unimodal sensorimotor to transmodal association areas. This hierarchy often characterized using low-dimensional embeddings, termed gradients, of interregional functional coupling estimates measured with resting-state magnetic resonance imaging. Such analyses may offer insights into the pathophysiology schizophrenia, which has been frequently linked dysfunctional interactions between and

Язык: Английский

Процитировано

15
Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson’s disease DOI Creative Commons
Marcelo Mendonça, Pedro Ferreira, Francisco P. M. Oliveira

и другие.

npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)

Опубликована: Ноя. 18, 2024

Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects Progression Markers Initiative, 57 additional PD patients and controls 86 referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen ratio, was higher in RT patients. Furthermore, baseline CBR linked development. In smaller cohorts, 4–6 Hz oscillation-based metric inertial sensors correlated amplitude, distinguished reduced DaT latter group. silico modelling uncovered that explained correlations between DaT-SPECT found several datasets, supporting spurious origin ipsilateral RT. These results suggest caudate terminals integrity feature of potential pathophysiological implications.

Язык: Английский

Процитировано

6
Association of Cortical and Subcortical Microstructure With Clinical Progression and Fluid Biomarkers in Patients With Parkinson Disease DOI
Linbo Wang, Cheng Zhou, Wei Zhang

и другие.

Neurology, Год журнала: 2023, Номер 101(3)

Опубликована: Май 18, 2023

Mean diffusivity (MD) of diffusion MRI (dMRI) has been used to measure cortical and subcortical microstructural properties. This study investigated relationships MD, clinical progression, fluid biomarkers in Parkinson disease (PD).

Язык: Английский

Процитировано

10
Neurotransmitter imbalance, glutathione depletion and concomitant susceptibility increase in Parkinson’s disease DOI Creative Commons
Yan Su,

Bingfang Duan,

Yuanhao Li

и другие.

NeuroImage Clinical, Год журнала: 2025, Номер unknown, С. 103740 - 103740

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Integrity of dopaminergic terminals in the caudate nucleus is relevant for rest tremor in Parkinson’s disease DOI Open Access
Marcelo Mendonça, Pedro Antônio Muniz Ferreira, Francisco P. M. Oliveira

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 6, 2024

Abstract Resting tremor (RT) is a Parkinson’s disease (PD) symptom whose relationship with the dopaminergic system remains puzzling. To clarify this relation, we analysed data from 432 subjects PPMI (Parkinson’s Progression Markers Initiative) database, second cohort of 57 PD patients and controls third 86 referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate, but not putamen binding potential (CBP, PBP) was higher in RT. The presence CBP at baseline relative sparing were related to development RT 2 nd year. In smaller cohorts, 4-6 Hz oscillation-based metric extracted inertial sensors correlated amplitude distinguished groups DA denervation controls. same CBP, PBP denervated DaT-SPECT. silico modelling uncovered that fundamental explain associations correlations between DaT-SPECT described our other datasets. These results support integrity caudate terminals could be relevant pathophysiology. Unbiased assessment methods, such as sensors, can important understand

Язык: Английский

Процитировано

3