Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Depression
represents
a
prevalent
and
enduring
mental
disorder
of
significant
concern
within
the
clinical
domain.
Extensive
research
indicates
that
depression
is
very
complex,
with
many
interconnected
pathways
involved.
Most
related
to
focuses
on
monoamines,
neurotrophic
factors,
hypothalamic-pituitary-adrenal
axis,
tryptophan
metabolism,
energy
mitochondrial
function,
gut-brain
glial
cell-mediated
inflammation,
myelination,
homeostasis,
brain
neural
networks.
However,
recently,
Ketamine,
an
ionotropic
N-methyl-D-aspartate
(NMDA)
receptor
antagonist,
has
been
discovered
have
rapid
antidepressant
effects
in
patients,
leading
novel
successful
treatment
approaches
for
mood
disorders.
This
review
aims
summarize
latest
findings
insights
into
various
signaling
systems
observed
patients
animal
models,
providing
more
comprehensive
view
neurobiology
anxious-depressive-like
behavior.
Specifically,
it
highlights
key
mechanisms
ketamine
as
rapid-acting
antidepressant,
aiming
enhance
neuropsychiatric
Moreover,
we
discuss
potential
prophylactic
or
therapeutic
intervention
stress-related
psychiatric
Translational Psychiatry,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 19, 2025
Depression
has
been
linked
to
cortico-limbic
brain
regions,
and
ketamine
is
known
for
its
rapid
antidepressant
effects.
However,
how
these
regions
encode
depression
collaboratively
regulates
exert
prompt
effects
through
mesoscale
brain-wide
fluctuations
remain
elusive.
In
this
study,
we
used
a
multidisciplinary
approach,
including
multi-region
in
vivo
recordings
mice,
chronic
social
defeat
stress
(CSDS),
machine
learning,
construct
Mesoscale
Brain-Wide
Fluctuation
Analysis
platform
(MBFA-platform).
This
analyzes
the
of
multiple
from
perspective
local
field
potential
oscillations
network
dynamics.
The
decoder
results
demonstrate
that
our
MBFA
can
accurately
classify
Control/CSDS
ketamine/saline-treated
groups
based
on
neural
oscillation
activities
among
eight
regions.
We
found
multiple-region
LFPs
patterns
are
disrupted
CSDS-induced
avoidance,
with
basolateral
amygdala
playing
key
role.
Ketamine
primarily
exerts
compensatory
dynamics,
contributing
effect.
These
findings
highlight
as
an
interdisciplinary
tool
revealing
underlying
complex
emotional
pathologies,
providing
insights
into
etiology
psychiatry.
Furthermore,
platform's
evaluation
capabilities
present
novel
approach
psychiatric
therapeutic
interventions.
Pharmacological Research,
Год журнала:
2023,
Номер
194, С. 106833 - 106833
Опубликована: Июнь 20, 2023
Life
stressors
can
wreak
havoc
on
our
health,
contributing
to
mood
disorders
like
major
depressive
disorder
(MDD),
a
widespread
and
debilitating
condition.
Unfortunately,
current
treatments
diagnostic
strategies
fall
short
of
addressing
these
disorders,
highlighting
the
need
for
new
approaches.
In
this
regard,
relationship
between
MDD,
brain
inflammation
(neuroinflammation),
systemic
in
body
may
offer
novel
insights.
Recent
research
has
uncovered
crucial
role
astrocytes
coordinating
inflammatory
response
through
release
extracellular
vesicles
(ADEVs)
during
different
neuroinflammatory
conditions.
While
contribution
ADEVs
stress
MDD
remains
largely
unexplored,
their
potential
modulate
immune
cells
contribute
pathogenesis
is
significant.
article,
we
delve
into
immunomodulatory
ADEVs,
impact
peripheral
cells,
how
microRNA
(miRNA)
landscape
hold
key
controlling
cell
activity.
Together,
mechanisms
constitute
an
opportunity
develop
therapeutic
pharmacological
approaches
tackle
disorders.
Psychological Medicine,
Год журнала:
2024,
Номер
54(9), С. 2042 - 2053
Опубликована: Апрель 2, 2024
Despite
extensive
research
into
the
neural
basis
of
autism
spectrum
disorder
(ASD),
presence
substantial
biological
and
clinical
heterogeneity
among
diagnosed
individuals
remains
a
major
barrier.
Commonly
used
case‒control
designs
assume
homogeneity
subjects,
which
limits
their
ability
to
identify
heterogeneity,
while
normative
modeling
pinpoints
deviations
from
typical
functional
network
development
at
individual
level.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Depression
represents
a
prevalent
and
enduring
mental
disorder
of
significant
concern
within
the
clinical
domain.
Extensive
research
indicates
that
depression
is
very
complex,
with
many
interconnected
pathways
involved.
Most
related
to
focuses
on
monoamines,
neurotrophic
factors,
hypothalamic-pituitary-adrenal
axis,
tryptophan
metabolism,
energy
mitochondrial
function,
gut-brain
glial
cell-mediated
inflammation,
myelination,
homeostasis,
brain
neural
networks.
However,
recently,
Ketamine,
an
ionotropic
N-methyl-D-aspartate
(NMDA)
receptor
antagonist,
has
been
discovered
have
rapid
antidepressant
effects
in
patients,
leading
novel
successful
treatment
approaches
for
mood
disorders.
This
review
aims
summarize
latest
findings
insights
into
various
signaling
systems
observed
patients
animal
models,
providing
more
comprehensive
view
neurobiology
anxious-depressive-like
behavior.
Specifically,
it
highlights
key
mechanisms
ketamine
as
rapid-acting
antidepressant,
aiming
enhance
neuropsychiatric
Moreover,
we
discuss
potential
prophylactic
or
therapeutic
intervention
stress-related
psychiatric
