ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Язык: Английский
Опубликована: Янв. 1, 2025
Ethnopharmacological relevance: Pterocarpus mildbraedii was believed to have multiple benefits, including antioxidant, antipyretic, antalgic, anti-convulsant, and anxiolytic effects. Previous studies reported that water extract (Pm) contained secondary metabolites able cross the BBB. However, Pm's systemic mechanism targets for neuroinflammation remain largely unexplored.Aim of study: This research used a systems pharmacology approach experiment evaluation reveal potential protective effects Pm against neuroinflammation, oxidative stress, behavioral changes in an LPS-induced Alzheimer's disease (AD) rat model.Materials methods: integrated network analysis experimental verification evaluate pharmacological PM AD systematically. Swiss Target Prediction, GeneCards, STRING databases were employed identify targets. The interaction between active components hub confirmed via molecular docking. GO KEGG pathway analyses also carried out. Further, vitro bioassays explore anti-inflammatory antioxidant activities and, finally, vivo neuroinflammatory stress markers.Results: Network docking revealed primarily regulates signaling pathways such as ESR1, ESR2, BACE1, MAPK1, TLR4, IL6, GSK3B through like liquiritigenin pterocarptriol. identified significant action AD, nitrogen metabolism VEGF pathway. In vitro, demonstrated their properties, along with inhibitory on AchE BchE. Behavioral tests showed LPS exposure impaired exploratory behavior, spatial learning, increased anxiety rats, correlating brain, marked by elevated MDA NO levels, decreased CAT, SOD, GSH levels. raised TNF-α IL-6 levels while reducing dopamine, serotonin, AChE activity. Notably, treatment significantly mitigated improved activity, restored neurotransmitter animals.Conclusion: paper established P. could inhibit its components, targets, pathways. milbraedii may be candidate treatment.
Язык: Английский
Процитировано
0
Journal of Ayurveda and Integrative Medicine, Год журнала: 2025, Номер 16(1), С. 101041 - 101041
Опубликована: Янв. 1, 2025
Multi-targeted drug therapy has received substantial attention for the treatment of diseases multi-factorial origin, including neurodegenerative and autoimmune diseases. It seems reasonable to argue that complex pathology (ND) cannot be reduced a single target modulate broad range cellular signaling, associated pathologies, symptoms. is this idea brought scientific world towards phytochemicals traditional drugs are notoriously multi-targeted. A systematic study these formulations establishing molecular pathways individual molecules can lead standardized multi-component product activities on different targets ND. This could provide an accessible affordable solution significant disease burden With in mind, review was carried out Ayurvedic Manasamitra Vatakam (MMV), known neuroprotective formulation highly effective against Alzheimer's disease. MMV source phytomolecules treating The multifactorial nature makes them suitable candidates testing due inherent multitargeting capabilities compounds. primary objective comprehensive understanding from responsible its multitargeted effect From reported literature, it clear many phytoconstituents extracts herbal ingredients have demonstrated their efficacy AD models. However, combination models never been tested. Scientific studies should done explore bioactive compounds druggability identified evaluated using experimental methods.
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(2), С. 225 - 225
Опубликована: Фев. 4, 2025
Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of found living cells. They regulating ion channels, metabolic flux, stress response, other key biological processes. While emerging research has highlighted significant roles immunity, cancer, diseases, there lack comprehensive reviews on their psychiatric neurological disorders. This review aims to fill that gap by analyzing existing literature importance severe conditions such as Parkinson’s disease, Alzheimer’s bipolar disorder, amyotrophic lateral sclerosis, schizophrenia, Huntington’s underscoring potential pave way new treatment regimens these debilitating disorders targeting pathways.
Язык: Английский
Процитировано
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111287 - 111287
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0