Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Advanced Materials, Год журнала: 2023, Номер 36(13)

Опубликована: Ноя. 6, 2023

Abstract Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly scalable therapeutic approach that involves technologies for both mRNA itself the delivery vehicle. Although there are some unique challenges different applications of therapy, common challenge all therapeutics is transport into target cell cytoplasm sufficient protein expression. This review focused on behaviors at cellular level nanotechnology‐mediated systems, which have not been comprehensively reviewed yet. First, four main introduced, including immunotherapy, replacement genome editing, reprogramming. Second, types cargos systems summarized. Third, strategies to enhance efficiency during trafficking process highlighted, accumulation cell, internalization endosomal escape, release from nanocarrier, translation protein. Finally, opportunities development presented. can provide new insights future fabrication nanocarriers with desirable performance.

Язык: Английский

---

In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future

Vaccines, Год журнала: 2023, Номер 11(10), С. 1600 - 1600

Опубликована: Окт. 16, 2023

mRNA was discovered in 1961, but it not used as a vaccine until after three decades. Recently, the development of technology gained great impetus from pursuit vaccines against COVID-19. To improve properties RNA vaccines, and primarily their circulation time, self-amplifying trans-amplifying were developed. A separate branch is circular which developed with discovery possibility translation on protein matrix. Circular has several advantages over considered fairly promising platform, mRNA. This review presents an overview platform critical discussion more modern mRNA, platforms created its basis. Finally, main features, advantages, disadvantages each presented are discussed. will facilitate decision-making process selecting most appropriate for creating cancer or viral diseases.

Язык: Английский

---

Lipoplexes’ Structure, Preparation, and Role in Managing Different Diseases

AAPS PharmSciTech, Год журнала: 2024, Номер 25(5)

Опубликована: Июнь 7, 2024

Язык: Английский

---

Design Principles for Immunomodulatory Biomaterials

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 26, 2024

The immune system is imperative to the survival of all biological organisms. A functional protects organism by detecting and eliminating foreign host aberrant molecules. Conversely, a dysfunctional characterized an overactive or weakened causes life-threatening autoimmune immunodeficiency diseases. Therefore, critical need exists develop technologies that regulate ensure homeostasis treat several Accumulating evidence shows biomaterials─artificial materials (polymers, metals, ceramics, engineered cells tissues) interact with systems─can trigger responses, offering science-based strategy modulate system. This Review discusses expanding frontiers biomaterial-based immunomodulation, focusing on principles for designing these materials. also presents examples immunomodulatory biomaterials, which include polymers metal- carbon-based nanomaterials, capable regulating innate adaptive systems.

Язык: Английский

---

Incorporation of poly(γ-glutamic acid) in lipid nanoparticles for enhanced mRNA delivery efficiency in vitro and in vivo

Acta Biomaterialia, Год журнала: 2024, Номер 177, С. 361 - 376

Опубликована: Фев. 10, 2024

Язык: Английский

---