Epithelial
Ovarian
Cancer
(EOC)
is
complex
and
heterogeneous,
making
accurate
prognosis
treatment
prediction
difficult.
New
therapeutic
targets
their
mechanisms
are
urgently
needed.
This
study
explored
the
role
of
PTTG1
in
ovarian
cancer
via
cGMP-PKG
signaling
pathway,
focusing
on
its
effects
M2
macrophage
polarization
EMT
progression
EOC
cells.
Using
GSE135886
database,
we
performed
differential
gene
expression,
pathway
enrichment,
immune
infiltration
analyses
to
identify
key
influencing
polarization.
We
then
constructed
knockdown
overexpression
cell
lines
assess
impact
proliferation,
migration,
invasion,
EMT,
vitro.
Analysis
revealed
that
differentially
expressed
genes
were
enriched
correlated
with
macrophages.
A2780
SK-OV-3
cells
promoted
while
enhancing
sGC,
PKG1,
PKG2
expression
activate
induce
produced
opposite
results,
reinforcing
our
conclusions.
uncovers
a
novel
mechanism
development
suggests
it
as
potential
target.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117093 - 117093
Опубликована: Июль 5, 2024
Protein
phosphorylation
is
an
important
link
in
a
variety
of
signaling
pathways,
and
most
the
life
processes
cells
involve
protein
phosphorylation.
Based
on
amino
acid
residues
phosphorylated
proteins,
kinases
can
be
categorized
into
following
families:
serine/threonine
kinases,
tyrosine-specific
histidine-specific
tryptophan
aspartate/glutamyl
kinases.
Of
all
are
where
that
catalyze
serine
or
threonine
target
proteins
using
ATP
as
phosphate
donor.
The
current
socially
accepted
classification
to
divide
them
seven
major
groups:
kinase
A,
G,
C
(AGC),
CMGC,
Calmodulin-dependent
(CAMK),
Casein
(CK1),
STE,
Tyrosine
(TKL)
others.
After
decades
research,
preliminary
understanding
specific
respective
functions
has
entered
new
period
exploration.
In
this
paper,
we
review
literature
previous
years
introduce
pathways
related
therapeutic
modalities
played
by
each
small
family,
respectively,
some
common
cardiovascular
system
diseases
such
heart
failure,
myocardial
infarction,
ischemia-reperfusion
injury,
diabetic
cardiomyopathy.
To
certain
extent,
research
results,
including
molecular
mechanisms
methods,
fully
summarized
systematic
report
made
for
prevention
treatment
future.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
Introduction
Diabetic
cardiomyopathy
(DCM)
is
predominantly
distinguished
by
impairment
in
ventricular
function
and
myocardial
fibrosis.
Previous
studies
revealed
the
cardioprotective
properties
of
C1q/tumor
necrosis
factor-related
protein
9
(CTRP9).
However,
whether
CTRP9
affects
diabetic
fibrosis
its
underlying
mechanisms
remains
unclear.
Methods
We
developed
a
type
1
diabetes
(T1DM)
model
CTRP9-KO
mice
via
streptozotocin
(STZ)
induction
to
examine
cardiac
function,
histopathology,
extent,
Yes-associated
(YAP)
expression,
expression
markers
for
autophagy
such
LC3-II
p62.
Additionally,
we
analyzed
direct
impact
on
high
glucose
(HG)-induced
transdifferentiation,
autophagic
activity,
YAP
levels
fibroblasts.
Results
In
mice,
was
decreased
heart.
The
absence
aggravated
dysfunction
with
diabetes,
alongside
increased
impaired
autophagy.
vitro
,
HG
induced
activation
fibroblasts,
which
demonstrated
elevated
cell
proliferation,
collagen
production,
α-smooth
muscle
actin
(α-SMA)
expression.
countered
these
adverse
effects
restoring
reducing
Notably,
protective
were
negated
inhibition
chloroquine
(CQ)
or
overexpression
through
plasmid
intervention.
effect
caused
intervention
overexpression.
Discussion
Our
findings
suggest
that
can
enhance
mitigate
remodeling
DCM
regulation
YAP-mediated
holds
promise
as
potential
candidate
pharmacotherapy
managing
International Journal of Cardiology Cardiovascular Risk and Prevention,
Год журнала:
2024,
Номер
24, С. 200355 - 200355
Опубликована: Дек. 6, 2024
Cardiovascular
diseases
(CVDs),
such
as
atherosclerotic
cardiovascular
diseases,
heart
failure
(HF),
and
acute
coronary
syndrome,
represent
a
significant
threat
to
global
health
impose
considerable
socioeconomic
burdens.
The
intricate
pathogenesis
of
CVD
involves
various
regulatory
mechanisms,
among
which
microRNAs
(miRNAs)
have
emerged
critical
posttranscriptional
regulators.
In
particular,
miR-155
has
demonstrated
differential
expression
patterns
across
spectrum
is
implicated
in
the
etiology
progression
arterial
disorders.
This
systematic
review
synthesizes
current
evidence
on
multifaceted
roles
modulation
genes
pathological
processes
associated
with
CVD.
We
delineate
potential
diagnostic
biomarker
therapeutic
target,
highlighting
its
influence
conditions
atherosclerosis,
aneurysm,
hypertension,
HF,
myocardial
hypertrophy,
oxidative
stress.
Our
analysis
underscores
transformative
target
for
intervention
medicine,
warranting
further
investigation
into
clinical
applicability.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 13, 2025
Diabetic
cardiomyopathy
(DCM)
is
one
of
the
most
prevalent
and
severe
complications
associated
with
diabetes
mellitus
(DM).
The
onset
DCM
insidious,
symptoms
being
obvious
only
in
late
stage.
Consequently,
early
diagnosis
a
formidable
challenge
which
significantly
influences
treatment
prognosis
DCM.
Thus,
it
becomes
imperative
to
uncover
innovative
approaches
facilitate
prompt
identification
On
traditional
clinical
side,
we
tend
use
serum
biomarkers
as
well
imaging
common
means
diagnosing
diseases
because
their
convenience
affordability.
As
delve
deeper
into
mechanisms
DCM,
wide
variety
are
becoming
competitive
diagnostic
indicators.
Meanwhile,
application
multiple
techniques
has
also
made
efforts
promote
Besides,
spurt
sequencing
technology
possible
give
hints
about
disease
from
genome
transcriptome,
making
less
difficult,
more
sensitive,
predictive.
Overall,
expected
be
superior
choice
plasma
for
detecting
lesions
at
an
earlier
stage
than
imaging,
its
judicious
utilization
combined
technologies
will
lead
sensitive
future.
Therefore,
this
review
meticulously
consolidates
progress
various
biomarkers,
methods,
realm
diagnosis,
aim
furnishing
novel
theoretical
foundation
guide
future
research
endeavors
towards
enhancing
therapeutic
landscape
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Diabetic
cardiomyopathy
(DCM)
is
one
of
the
common
diabetic
microangiopathy
in
clinical
practice.
In
early
stage
disease,
there
are
no
obvious
symptoms.
middle
and
late
stages,
MF,
arrhythmia,
even
heart
failure
may
occur,
affecting
life
health
patients.
as
pathological
features
DCM
at
end
stage,
key
factor
poor
prognosis
leading
to
ventricular
wall
stiffness
failure,
which
affects
process
outcome
The
development
MF
a
high
glucose
environment
involves
multiple
complex
fibrogenic
pathways
that
work
together
activate
fibroblasts,
thereby
promoting
MF.
Indeed,
aberrant
activation
cardiac
fibroblasts
(CFs)
Therefore,
inhibiting
CFs
become
new
strategy
for
treatment
DCM.
Previous
studies
have
shown
Chinese
herbal
medicine
(CHM)
has
potential
this
review,
we
first
introduced
physiology
function
discussed
conditions
diabetes,
then
systematically
summarized
effects
CHM
on
by
controlling
production
advanced
glycosylation
products,
oxidative
stress
inflammation.
This
review
will
illustrate
inhibit
provide
ideas
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1465 - 1465
Опубликована: Фев. 10, 2025
Diabetic
cardiomyopathy
(DCM)
is
one
of
the
cardiovascular
complications
diabetes,
characterized
by
development
ventricular
systolic
and
diastolic
dysfunction
due
to
factors
such
as
inflammation,
oxidative
stress,
fibrosis,
disordered
glucose
metabolism.
As
a
sustainable
therapeutic
approach,
exercise
has
been
reported
in
numerous
studies
regulate
blood
improve
abnormal
energy
metabolism
through
various
mechanisms,
thereby
ameliorating
left
mitigating
DCM.
This
review
summarizes
positive
impacts
on
DCM
explores
its
underlying
molecular
providing
new
insights
paving
way
for
tailored
programs
prophylaxis
therapy
Acute
myocardial
infarction
(AMI)
is
a
serious
cardiovascular
disease
for
which
there
are
still
no
effective
therapeutic
options
available,
and
melanoma-associated
antigen-A13
(Magea13),
member
of
the
MAGE
superfamily,
has
an
unknown
role
in
AMI.
This
study
aims
to
investigate
potential
molecular
mechanisms
Magea13
injury
associated
with
AMI
through
vivo
vitro
experiments.
Firstly,
differentially
expressed
genes
(DEGs)
signaling
pathways
were
screened
by
RNA
sequencing.
Cardiac-specific
overexpression
was
achieved
adeno-associated
virus
type
9
serotype
system.
Subsequently,
these
rats
underwent
left
anterior
descending
coronary
artery
(LAD)
ligation,
followed
histopathological
examination,
biochemical
assay,
Western
blot
analysis
evaluate
efficacy
feasibility
Meanwhile,
Magea13-overexpressing
rat
cardiomyocyte
cell
line
(H9c2)
also
subjected
hypoxia-glucose
deficiency/reperfusion
mimic
further
validate
its
effects
vitro.
The
cardiomyocyte-specific
observed
attenuate
acute
infarction.
Furthermore,
demonstrated
OGD/R-induced
H9c2
injury.
Mechanistic
studies
have
suggested
that
protective
effect
may
be
mediated
cAMP-PKA
pathway.
been
offer
protection
against
pathway
therefore
promising
predictive
target
