Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind DOI Creative Commons

Adrina Kocharian,

A. David Redish, Patrick E. Rothwell

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

ABSTRACT Nucleus accumbens dopamine signaling is an important neural substrate for decision-making. Dominant theories generally discretize and homogenize decision-making, when it in fact a continuous process, with evaluation re-evaluation components that extend beyond simple outcome prediction into consideration of past future value. Extensive work has examined mesolimbic the context reward error, but major gaps persist our understanding how regulates volitional self-guided Moreover, there little individual differences value processing may shape Here, using economic foraging task mice, we found dynamics nucleus core reflected decision confidence during decisions, as well both change-of-mind. Optogenetic manipulations release selectively altered decisions mice whose behavior

Язык: Английский

Neurobiological basis of stress resilience DOI
Eric J. Nestler, Scott J. Russo

Neuron, Год журнала: 2024, Номер 112(12), С. 1911 - 1929

Опубликована: Май 24, 2024

Язык: Английский

Процитировано

32
Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders DOI
Trevonn Gyles, Eric J. Nestler, Eric M. Parise

и другие.

Neuropsychopharmacology, Год журнала: 2023, Номер 49(1), С. 215 - 226

Опубликована: Июнь 22, 2023

Язык: Английский

Процитировано

19
Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning DOI Creative Commons
Joeri Bordes, Lucas Miranda, Bertram Müller−Myhsok

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 151, С. 105243 - 105243

Опубликована: Май 22, 2023

Social behavior is naturally occurring in vertebrate species, which holds a strong evolutionary component and crucial for the normal development survival of individuals throughout life. Behavioral neuroscience has seen different influential methods social behavioral phenotyping. The ethological research approach extensively investigated natural habitats, while comparative psychology was developed utilizing standardized univariate tests. advanced precise tracking tools, together with post-tracking analysis packages, recently enabled novel phenotyping method, that includes strengths both approaches. implementation such will be beneficial fundamental but also enable an increased understanding influences many factors can influence behavior, as stress exposure. Furthermore, future increase number data modalities, sensory, physiological, neuronal activity data, thereby significantly enhance our biological basis guide intervention strategies abnormalities psychiatric disorders.

Язык: Английский

Процитировано

18
Sex differences in change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex DOI Open Access
Romain Durand-de Cuttoli, Orna Issler, Samantha Pedersen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 8, 2024

Changing one's mind involves re-appraisals between past-costs versus future-value and may be altered in psychopathology. Long intergenic non-coding RNA LINC00473 medial prefrontal cortex (mPFC) can induce stress-resilience a sex-dependent manner, but its role cognition is unknown. We characterized decision-making behavior male female mice the neuroeconomic paradigm Restaurant Row following virus-mediated expression of mPFC. Mice foraged for food among varying temporal-costs subjective-value while on limited time-budget. Without affecting primary deliberative decisions, selectively influenced re-evaluative choices manner. This included changing how (i) cached value with passage time (ii) weighed prior mistakes, which underlie computational bases sensitivity to sunk costs regret. These findings suggest common function shared these processes reveal bridge molecular drivers psychological mechanisms underlying sex-specific proclivities negative rumination.

Язык: Английский

Процитировано

3
Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes DOI Creative Commons
Chinonso A. Nwakama, Romain Durand-de Cuttoli,

Zainab Oketokoun

и другие.

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 21, 2025

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, especially mood yet the link between hyperglycemia and altered motivation has not been thoroughly explored. Here, we characterized value-based decision-making behavior a streptozocin-induced diabetic mouse model on Restaurant Row, naturalistic neuroeconomic foraging paradigm capable behaviorally capturing multiple decision systems known to depend dissociable neural circuits. Mice made self-paced choices daily limited time-budget, accepting or rejecting reward offers based cost (delays cued by tone pitch) subjective value (flavors), in closed-economy system tested across months. We found streptozocin-treated mice disproportionately undervalued less-preferred flavors inverted their meal-consumption patterns shifted toward more costly strategy overprioritizing high-value rewards. These behaviors were driven impairments processes, including ability deliberate when engaged conflict cache passage time as sunk costs. Surprisingly, diabetes-induced changes depended only type choice being made, but also salience reward-scarcity environment. findings suggest that complex relationships metabolic dysfunction valuation algorithms underlying unique cognitive heuristics sensitivity opportunity costs can disrupt distinct computational processes leading comorbid vulnerabilities. A approach characterize reveals alterations diabetes, shedding light interaction energy balance, heuristics.

Язык: Английский

Процитировано

0
Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress DOI Creative Commons
Leanne M. Holt, Trevonn Gyles, Eric M. Parise

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 16, 2024

Abstract Background Increasing evidence implicates astrocytes in stress and depression both rodent models human Major Depressive Disorder (MDD). Despite this, little is known about the transcriptional responses to of within nucleus accumbens (NAc), a key brain reward region, their influence on behavioral outcomes. Methods We used whole cell sorting, RNA-sequencing, bioinformatic analyses investigate NAc astrocyte transcriptome male mice response chronic social defeat (CSDS). Immunohistochemistry was determine stress-induced changes astrocytic CREB NAc. Finally, regulation depression-like behavior investigated using viral-mediated manipulation combination with CSDS. Results found robust CSDS stressed mice, seen stress-susceptible stress-resilient animals. Bioinformatic analysis revealed CREB, transcription factor widely studied neurons, as one top-predicted upstream regulators transcriptome, opposite activation states resilient versus susceptible mice. This result confirmed at protein level immunohistochemistry. Viral overexpression selectively promoted susceptibility stress. Conclusions Together, our data demonstrate that responds robustly and, for first time, contributes depressive-like behaviors. A better understanding may reveal unknown molecular mechanisms underlying neuropsychiatric disorders.

Язык: Английский

Процитировано

2
Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress DOI
Leanne M. Holt, Trevonn Gyles, Eric M. Parise

и другие.

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

2
Sunk cost sensitivity during change-of-mind decisions is informed by both the spent and remaining costs DOI Creative Commons
A. David Redish, Samantha V. Abram, Paul J. Cunningham

и другие.

Communications Biology, Год журнала: 2022, Номер 5(1)

Опубликована: Дек. 7, 2022

Sunk cost sensitivity describes escalating decision commitment with increased spent resources. On neuroeconomic foraging tasks, mice, rats, and humans show similar escalations from sunk costs while quitting an ongoing countdown to reward. In a new analysis taken across computationally parallel tasks species laboratories, we find that these behaviors primarily occur on choices are economically inconsistent the subject's other choices, they reflect not only time spent, but also remaining, suggesting change-of-mind re-evaluation processes. Using recently proposed drift-diffusion model, in this model arises decision-processes directly take into account (costs sunk). Applying insights experimental data, during decisions depends information provided subject about remaining.

Язык: Английский

Процитировано

8
Pushing the boundaries of behavioral analysis could aid psychiatric drug discovery DOI Creative Commons
Brian M. Sweis, Eric J. Nestler

PLoS Biology, Год журнала: 2022, Номер 20(12), С. e3001904 - e3001904

Опубликована: Дек. 8, 2022

Drug discovery for psychiatric conditions is stagnating. Behavioral changes could be used as a primary phenotypic screen new drug candidates, if enough useful data can generated from behavioral models. Could machine learning the answer to extracting we need?

Язык: Английский

Процитировано

7
Resilience and Vulnerability to Stress-Induced Anhedonia: Unveiling Brain Gene Expression and Mitochondrial Dynamics in a Mouse Chronic Stress Depression Model DOI Creative Commons
Tatyana Strekalova, Evgeniy Svirin, Anna Gorlova

и другие.

Biomolecules, Год журнала: 2023, Номер 13(12), С. 1782 - 1782

Опубликована: Дек. 12, 2023

The role of altered brain mitochondrial regulation in psychiatric pathologies, including Major Depressive Disorder (MDD), has attracted increasing attention. Aberrant functions were suggested to underlie distinct inter-individual vulnerability stress-related MDD syndrome. In this context, insulin receptor sensitizers (IRSs) that regulate metabolism have become a focus recent research, as their use pre-clinical studies can help elucidate the dynamics disorder and contribute development new antidepressant treatment. Here, following 2-week chronic mild stress (CMS) using predation, social defeat, restraint, MDD-related behaviour molecular markers been investigated along with hippocampus-dependent performance emotionality mice received IRS dicholine succinate (DS). sucrose test, studied for key feature MDD, decreased sensitivity reward, called anhedonia. Based on animals assigned anhedonic resilient-to-stress-induced-anhedonia groups, previously established criterion decrease preference below 65%. Such assignment was based fact none control, non-stressed displayed would be smaller than value. DS-treated stressed ameliorated behaviours battery assays: preference, coat state, Y-maze, marble tail suspension, nest building. CMS-vulnerable exhibited overexpression inflammatory Il-1β, tnf, Cox-1, well 5-htt 5-ht2a-R, various regions. alterations hippocampal gene expression closest clinical findings further. DS-treated, showed normalised plasticity Camk4, Camk2, Pka, Adcy1, Creb-ar, Nmda-2r-ar, Nmda-2r-s. non-treated who resilient or vulnerable anhedonia compared pathway Illumina profiling. Resilient revealed complexes NADH dehydrogenase, cytochrome bc1, c oxidase, F-type V-type ATPases, inorganic pyrophosphatase, which mice. DS partially both ATPases. We conclude reduction ATP synthesis is associated pro-inflammatory changes are by DS.

Язык: Английский

Процитировано

4