bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
ABSTRACT
Nucleus
accumbens
dopamine
signaling
is
an
important
neural
substrate
for
decision-making.
Dominant
theories
generally
discretize
and
homogenize
decision-making,
when
it
in
fact
a
continuous
process,
with
evaluation
re-evaluation
components
that
extend
beyond
simple
outcome
prediction
into
consideration
of
past
future
value.
Extensive
work
has
examined
mesolimbic
the
context
reward
error,
but
major
gaps
persist
our
understanding
how
regulates
volitional
self-guided
Moreover,
there
little
individual
differences
value
processing
may
shape
Here,
using
economic
foraging
task
mice,
we
found
dynamics
nucleus
core
reflected
decision
confidence
during
decisions,
as
well
both
change-of-mind.
Optogenetic
manipulations
release
selectively
altered
decisions
mice
whose
behavior
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
151, С. 105243 - 105243
Опубликована: Май 22, 2023
Social
behavior
is
naturally
occurring
in
vertebrate
species,
which
holds
a
strong
evolutionary
component
and
crucial
for
the
normal
development
survival
of
individuals
throughout
life.
Behavioral
neuroscience
has
seen
different
influential
methods
social
behavioral
phenotyping.
The
ethological
research
approach
extensively
investigated
natural
habitats,
while
comparative
psychology
was
developed
utilizing
standardized
univariate
tests.
advanced
precise
tracking
tools,
together
with
post-tracking
analysis
packages,
recently
enabled
novel
phenotyping
method,
that
includes
strengths
both
approaches.
implementation
such
will
be
beneficial
fundamental
but
also
enable
an
increased
understanding
influences
many
factors
can
influence
behavior,
as
stress
exposure.
Furthermore,
future
increase
number
data
modalities,
sensory,
physiological,
neuronal
activity
data,
thereby
significantly
enhance
our
biological
basis
guide
intervention
strategies
abnormalities
psychiatric
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 8, 2024
Changing
one's
mind
involves
re-appraisals
between
past-costs
versus
future-value
and
may
be
altered
in
psychopathology.
Long
intergenic
non-coding
RNA
LINC00473
medial
prefrontal
cortex
(mPFC)
can
induce
stress-resilience
a
sex-dependent
manner,
but
its
role
cognition
is
unknown.
We
characterized
decision-making
behavior
male
female
mice
the
neuroeconomic
paradigm
Restaurant
Row
following
virus-mediated
expression
of
mPFC.
Mice
foraged
for
food
among
varying
temporal-costs
subjective-value
while
on
limited
time-budget.
Without
affecting
primary
deliberative
decisions,
selectively
influenced
re-evaluative
choices
manner.
This
included
changing
how
(i)
cached
value
with
passage
time
(ii)
weighed
prior
mistakes,
which
underlie
computational
bases
sensitivity
to
sunk
costs
regret.
These
findings
suggest
common
function
shared
these
processes
reveal
bridge
molecular
drivers
psychological
mechanisms
underlying
sex-specific
proclivities
negative
rumination.
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 21, 2025
Those
with
diabetes
mellitus
are
at
high-risk
of
developing
psychiatric
disorders,
especially
mood
yet
the
link
between
hyperglycemia
and
altered
motivation
has
not
been
thoroughly
explored.
Here,
we
characterized
value-based
decision-making
behavior
a
streptozocin-induced
diabetic
mouse
model
on
Restaurant
Row,
naturalistic
neuroeconomic
foraging
paradigm
capable
behaviorally
capturing
multiple
decision
systems
known
to
depend
dissociable
neural
circuits.
Mice
made
self-paced
choices
daily
limited
time-budget,
accepting
or
rejecting
reward
offers
based
cost
(delays
cued
by
tone
pitch)
subjective
value
(flavors),
in
closed-economy
system
tested
across
months.
We
found
streptozocin-treated
mice
disproportionately
undervalued
less-preferred
flavors
inverted
their
meal-consumption
patterns
shifted
toward
more
costly
strategy
overprioritizing
high-value
rewards.
These
behaviors
were
driven
impairments
processes,
including
ability
deliberate
when
engaged
conflict
cache
passage
time
as
sunk
costs.
Surprisingly,
diabetes-induced
changes
depended
only
type
choice
being
made,
but
also
salience
reward-scarcity
environment.
findings
suggest
that
complex
relationships
metabolic
dysfunction
valuation
algorithms
underlying
unique
cognitive
heuristics
sensitivity
opportunity
costs
can
disrupt
distinct
computational
processes
leading
comorbid
vulnerabilities.
A
approach
characterize
reveals
alterations
diabetes,
shedding
light
interaction
energy
balance,
heuristics.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 16, 2024
Abstract
Background
Increasing
evidence
implicates
astrocytes
in
stress
and
depression
both
rodent
models
human
Major
Depressive
Disorder
(MDD).
Despite
this,
little
is
known
about
the
transcriptional
responses
to
of
within
nucleus
accumbens
(NAc),
a
key
brain
reward
region,
their
influence
on
behavioral
outcomes.
Methods
We
used
whole
cell
sorting,
RNA-sequencing,
bioinformatic
analyses
investigate
NAc
astrocyte
transcriptome
male
mice
response
chronic
social
defeat
(CSDS).
Immunohistochemistry
was
determine
stress-induced
changes
astrocytic
CREB
NAc.
Finally,
regulation
depression-like
behavior
investigated
using
viral-mediated
manipulation
combination
with
CSDS.
Results
found
robust
CSDS
stressed
mice,
seen
stress-susceptible
stress-resilient
animals.
Bioinformatic
analysis
revealed
CREB,
transcription
factor
widely
studied
neurons,
as
one
top-predicted
upstream
regulators
transcriptome,
opposite
activation
states
resilient
versus
susceptible
mice.
This
result
confirmed
at
protein
level
immunohistochemistry.
Viral
overexpression
selectively
promoted
susceptibility
stress.
Conclusions
Together,
our
data
demonstrate
that
responds
robustly
and,
for
first
time,
contributes
depressive-like
behaviors.
A
better
understanding
may
reveal
unknown
molecular
mechanisms
underlying
neuropsychiatric
disorders.
Communications Biology,
Год журнала:
2022,
Номер
5(1)
Опубликована: Дек. 7, 2022
Sunk
cost
sensitivity
describes
escalating
decision
commitment
with
increased
spent
resources.
On
neuroeconomic
foraging
tasks,
mice,
rats,
and
humans
show
similar
escalations
from
sunk
costs
while
quitting
an
ongoing
countdown
to
reward.
In
a
new
analysis
taken
across
computationally
parallel
tasks
species
laboratories,
we
find
that
these
behaviors
primarily
occur
on
choices
are
economically
inconsistent
the
subject's
other
choices,
they
reflect
not
only
time
spent,
but
also
remaining,
suggesting
change-of-mind
re-evaluation
processes.
Using
recently
proposed
drift-diffusion
model,
in
this
model
arises
decision-processes
directly
take
into
account
(costs
sunk).
Applying
insights
experimental
data,
during
decisions
depends
information
provided
subject
about
remaining.
PLoS Biology,
Год журнала:
2022,
Номер
20(12), С. e3001904 - e3001904
Опубликована: Дек. 8, 2022
Drug
discovery
for
psychiatric
conditions
is
stagnating.
Behavioral
changes
could
be
used
as
a
primary
phenotypic
screen
new
drug
candidates,
if
enough
useful
data
can
generated
from
behavioral
models.
Could
machine
learning
the
answer
to
extracting
we
need?
Biomolecules,
Год журнала:
2023,
Номер
13(12), С. 1782 - 1782
Опубликована: Дек. 12, 2023
The
role
of
altered
brain
mitochondrial
regulation
in
psychiatric
pathologies,
including
Major
Depressive
Disorder
(MDD),
has
attracted
increasing
attention.
Aberrant
functions
were
suggested
to
underlie
distinct
inter-individual
vulnerability
stress-related
MDD
syndrome.
In
this
context,
insulin
receptor
sensitizers
(IRSs)
that
regulate
metabolism
have
become
a
focus
recent
research,
as
their
use
pre-clinical
studies
can
help
elucidate
the
dynamics
disorder
and
contribute
development
new
antidepressant
treatment.
Here,
following
2-week
chronic
mild
stress
(CMS)
using
predation,
social
defeat,
restraint,
MDD-related
behaviour
molecular
markers
been
investigated
along
with
hippocampus-dependent
performance
emotionality
mice
received
IRS
dicholine
succinate
(DS).
sucrose
test,
studied
for
key
feature
MDD,
decreased
sensitivity
reward,
called
anhedonia.
Based
on
animals
assigned
anhedonic
resilient-to-stress-induced-anhedonia
groups,
previously
established
criterion
decrease
preference
below
65%.
Such
assignment
was
based
fact
none
control,
non-stressed
displayed
would
be
smaller
than
value.
DS-treated
stressed
ameliorated
behaviours
battery
assays:
preference,
coat
state,
Y-maze,
marble
tail
suspension,
nest
building.
CMS-vulnerable
exhibited
overexpression
inflammatory
Il-1β,
tnf,
Cox-1,
well
5-htt
5-ht2a-R,
various
regions.
alterations
hippocampal
gene
expression
closest
clinical
findings
further.
DS-treated,
showed
normalised
plasticity
Camk4,
Camk2,
Pka,
Adcy1,
Creb-ar,
Nmda-2r-ar,
Nmda-2r-s.
non-treated
who
resilient
or
vulnerable
anhedonia
compared
pathway
Illumina
profiling.
Resilient
revealed
complexes
NADH
dehydrogenase,
cytochrome
bc1,
c
oxidase,
F-type
V-type
ATPases,
inorganic
pyrophosphatase,
which
mice.
DS
partially
both
ATPases.
We
conclude
reduction
ATP
synthesis
is
associated
pro-inflammatory
changes
are
by
DS.