A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies

Biological Psychiatry, Год журнала: 2023, Номер 96(1), С. 67 - 78

Опубликована: Дек. 21, 2023

Язык: Английский

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Ketamine reverses stress-induced hypersensitivity to sunk costs

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 14, 2024

How mood interacts with information processing in the brain is thought to mediate maladaptive behaviors observed depressed individuals. However, neural mechanisms underlying impairments emotion-cognition interactions are poorly understood. This includes influencing balance between how past-sensitive vs. future-looking one during decision-making. Recent insights from field of neuroeconomics offer novel approaches study changes such valuation processes a manner that biologically tractable and readily translatable across species. We recently discovered rodents sensitive "sunk costs" - feature higher cognition previously be unique humans. The sunk costs bias describes phenomenon which an individual overvalues escalates commitment continuing ongoing endeavor, even if suboptimal, as function irrecoverable past (sunk) losses that, according classic economic theory, should ignored. In present study, mice were exposed chronic social defeat stress paradigm, well-established animal model used for depression. Mice then tested on our longitudinal neuroeconomic foraging task, Restaurant Row. found this severe stressor displayed increased sensitivity costs, without altering overall willingness wait. randomly assigned receive single intraperitoneal injection either saline or ketamine (20 mg/kg). stress-induced hypersensitivity was renormalized following dose ketamine. Interestingly, non-defeated mice, treatment completely abolished cost sensitivity, causing no longer value re-evaluation decisions who instead based choices solely future investment required obtain goal. These findings suggest antidepressant effects may mediated part through on-going decision-making, reducing its weight potential source cognitive dissonance could modulate behavior promoting more future-thinking behavior.

Язык: Английский

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A double-hit of social and economic stress in mice precipitates changes in decision-making strategies

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Март 19, 2023

Economic stress can serve as a “second-hit” for those who already accumulated history of adverse life experiences. How one recovers from setback is core feature resilience but seldom captured in animal studies. We challenged mice novel two-hit model by exposing animals to chronic social defeat (first-hit) and then testing how adapt reward scarcity on neuroeconomic task (second-hit). Mice were tested longitudinally across months the Restaurant Row during which foraged daily their sole source food while limited time budget. An abrupt transition into reward-scarce environment this elicits an economic crisis, precipitating massive drop intake body weight must respond order survive. found that with mounted robust behavioral response challenge. This recovery was achieved through complex redistribution allocated among competing opportunities via multiple valuation algorithms. Interestingly, we displayed changes development decision-making policies process important not only ensuring security necessary survival also prioritizing subjective value. These findings indicate individual’s capacity “bounce back” depends one’s prior affect aspects well-being, highlighting motivational balance may be altered stress-related disorders such depression. In Brief Durand-de Cuttoli et al. after stress, when subsequently foraging task, stressor “second hit” reveal strategies maintaining between well-being.

Язык: Английский

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Diabetes alters neuroeconomically dissociable forms of mental accounting

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 4, 2024

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, yet the link between hyperglycemia and alterations in motivated behavior has not been explored detail. We characterized value-based decision-making a streptozocin-induced diabetic mouse model on naturalistic neuroeconomic foraging paradigm called Restaurant Row. Mice made self-paced choices while limited time-budget accepting or rejecting reward offers as function cost (delays cued by tone-pitch) subjective value (flavors), tested daily closed-economy system across months. found streptozocin-treated mice disproportionately undervalued less-preferred flavors inverted their meal-consumption patterns shifted toward more costly strategy that overprioritized high-value rewards. discovered these behaviors were driven impairments multiple systems, including ability to deliberate when engaged conflict cache passage time form sunk costs. Surprisingly, diabetes-induced changes depended only type choice being but also salience reward-scarcity environment. These findings suggest complex relationships glycemic regulation dissociable valuation algorithms underlying unique cognitive heuristics sensitivity opportunity costs can disrupt fundamentally distinct computational processes could give rise vulnerabilities.

Язык: Английский

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A widespread electrical brain network encodes anxiety in health and depressive states

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 30, 2024

Abstract In rodents, anxiety is charactered by heightened vigilance during low-threat and uncertain situations. Though activity in the frontal cortex limbic system are fundamental to supporting this internal state, underlying network architecture that integrates across brain regions encode animals paradigms remains unclear. Here, we utilize parallel electrical recordings freely behaving mice, translational known induce anxiety, machine learning discover a multi-region encodes anxious brain-state. The composed of circuits widely implicated behavior, it generalizes many behavioral contexts fails multiple do not. Strikingly, also principally altered two mouse models depression. Thus, establish network-level process whereby health disease.

Язык: Английский

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Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

ABSTRACT Nucleus accumbens dopamine signaling is an important neural substrate for decision-making. Dominant theories generally discretize and homogenize decision-making, when it in fact a continuous process, with evaluation re-evaluation components that extend beyond simple outcome prediction into consideration of past future value. Extensive work has examined mesolimbic the context reward error, but major gaps persist our understanding how regulates volitional self-guided Moreover, there little individual differences value processing may shape Here, using economic foraging task mice, we found dynamics nucleus core reflected decision confidence during decisions, as well both change-of-mind. Optogenetic manipulations release selectively altered decisions mice whose behavior

Язык: Английский

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