bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 11, 2023
Abstract
Hippocampus
and
entorhinal
cortex
encode
spaces
by
spatially
local
hexagonal
grid
activity
patterns
(place
cells
cells),
respectively.
In
addition,
the
same
brain
regions
also
implicate
neural
representations
for
non-spatial,
semantic
concepts
(concept
cells).
These
observations
suggest
that
neurocomputational
mechanisms
spatial
knowledge
are
related
in
brain.
However,
exact
relationship
remains
to
be
understood.
Here
we
show
a
mathematical
correspondence
between
value
function
goal-directed
navigation
an
information
measure
word
embedding
models
natural
language
processing.
Based
on
this
relationship,
integrate
computations
into
representation
model
called
as
“disentangled
successor
information”
(DSI).
DSI
generates
biologically
plausible
representations:
like
place
cells,
concept-specific
which
resemble
concept
cells.
Furthermore,
with
representations,
can
perform
inferences
of
contexts
words
common
computational
framework
based
simple
arithmetic
operations.
This
computation
interpreted
partial
modulations
cell
assemblies
non-grid
Our
offers
theoretical
connection
suggests
possible
roles
hippocampal
representations.
Nature Human Behaviour,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
Scientific
discoveries
often
hinge
on
synthesizing
decades
of
research,
a
task
that
potentially
outstrips
human
information
processing
capacities.
Large
language
models
(LLMs)
offer
solution.
LLMs
trained
the
vast
scientific
literature
could
integrate
noisy
yet
interrelated
findings
to
forecast
novel
results
better
than
experts.
Here,
evaluate
this
possibility,
we
created
BrainBench,
forward-looking
benchmark
for
predicting
neuroscience
results.
We
find
surpass
experts
in
experimental
outcomes.
BrainGPT,
an
LLM
tuned
literature,
performed
yet.
Like
experts,
when
indicated
high
confidence
their
predictions,
responses
were
more
likely
be
correct,
which
presages
future
where
assist
humans
making
discoveries.
Our
approach
is
not
specific
and
transferable
other
knowledge-intensive
endeavours.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2025,
Номер
unknown, С. 106089 - 106089
Опубликована: Март 1, 2025
Emotion
knowledge
is
organized
in
a
two-dimensional
space
known
as
the
affective
circumplex,
which
thought
to
develop
from
core
feelings
and
co-occurrence
of
emotional
events.
Neural
studies
reveal
that
emotion
concepts
cognitive
maps
abstract
are
represented
hippocampal-prefrontal
systems.
We
propose
circumplex
formed
by
learning
transitions
between
concepts,
process
mediated
reciprocal
network
involving
hippocampal
cells
encode
grid
medial
entorhinal
ventral
prefrontal
cortices
relations
them.
anticipate
testing
this
hypothesis
will
shed
light
on
debate
about
whether
emotions
biologically
basic
or
constructed
dimensions.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(11)
Опубликована: Март 10, 2025
The
hippocampus
and
entorhinal
cortex
encode
spaces
by
spatially
local
hexagonal
grid
activity
patterns
(place
cells
cells),
respectively.
In
addition,
the
same
brain
regions
also
implicate
neural
representations
for
nonspatial,
semantic
concepts
(concept
cells).
These
observations
suggest
that
neurocomputational
mechanisms
spatial
knowledge
are
related
in
brain.
However,
exact
relationship
remains
to
be
understood.
Here,
we
show
a
mathematical
correspondence
between
value
function
goal-directed
navigation
an
information
measure
word
embedding
models
natural
language
processing.
Based
on
this
relationship,
integrate
computations
into
representation
model
called
“disentangled
successor
information”
(DSI).
DSI
generates
biologically
plausible
representations:
like
place
cells,
concept-specific
which
resemble
concept
cells.
Furthermore,
with
representations,
can
perform
inferences
of
contexts
words
common
computational
framework
based
simple
arithmetic
operations.
This
computation
interpreted
partial
modulations
cell
assemblies
nongrid
Our
offers
theoretical
connection
suggests
possible
roles
hippocampal
representations.
Philosophia,
Год журнала:
2024,
Номер
52(4), С. 865 - 882
Опубликована: Май 8, 2024
Abstract
This
article
takes
a
cognitive
approach
to
natural
concepts.
The
aim
is
introduce
criteria
that
are
evaluated
with
respect
how
they
support
the
economy
of
humans
when
using
concepts
in
reasoning
and
communicating
them.
I
first
present
theory
conceptual
spaces
as
tool
for
expressing
criteria.
Then
central
idea
correspond
convex
regions
space.
argue
this
criterion
has
far-reaching
consequences
regards
Partly
following
earlier
work,
some
other
further
delimit
class
One
these
coherence,
which
does
not
seem
have
been
discussed
previously.
Finally,
show
convexity
make
it
possible
ensure
people
mean
same
thing
communicate
Apart
from
its
philosophical
interest,
analysis
presented
will
be
relevant
tasks
engineering
artificial
systems
work
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 12, 2024
Summary
Discoveries
of
functional
cell
types,
exemplified
by
the
cataloging
spatial
cells
in
hippocampal
formation,
are
heralded
as
scientific
breakthroughs.
We
question
whether
identification
types
based
on
human
intuitions
has
merit
and
suggest
that
“spatial
cells”
may
arise
non-spatial
computations
sufficient
complexity.
show
deep
neural
networks
(DNNs)
for
object
recognition,
which
lack
grounding,
contain
numerous
units
resembling
place,
border,
head-direction
cells.
Strikingly,
even
untrained
DNNs
with
randomized
weights
contained
such
support
decoding
information.
Moreover,
when
these
“spatial”
excluded,
information
can
be
decoded
from
remaining
DNN
units,
highlights
superfluousness
to
cognition.
Now
large-scale
simulations
feasible,
complexity
brain
should
respected
intuitive
notions
type,
misleading
any
complex
network,
relegated
history.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 16, 2024
Abstract
While
the
hippocampus
is
key
for
human
cognitive
abilities,
it
also
a
phylogenetically
old
cortex
and
paradoxically
considered
evolutionarily
preserved.
Here,
we
introduce
comparative
framework
to
quantify
preservation
reconfiguration
of
hippocampal
organisation
in
primate
evolution,
by
analysing
as
an
unfolded
cortical
surface
that
geometrically
matched
across
species.
Our
findings
revealed
overall
conservation
macro-
micro-structure,
which
shows
anterior-posterior
and,
perpendicularly,
subfield-related
organisational
axes
both
humans
macaques.
However,
while
functional
species
followed
axis,
observed
marked
latter
species,
mirrors
rudimentary
integration
default-mode-network
non-human
primates.
Here
show
microstructurally
preserved
regions
like
may
still
undergo
due
their
embedding
within
heteromodal
association
networks.
Brain,
Год журнала:
2024,
Номер
147(11), С. 3918 - 3932
Опубликована: Июль 25, 2024
Abstract
Declarative
memory
encompasses
episodic
and
semantic
divisions.
Episodic
captures
singular
events
with
specific
spatiotemporal
relationships,
whereas
houses
context-independent
knowledge.
Behavioural
functional
neuroimaging
studies
have
revealed
common
distinct
neural
substrates
of
both
systems,
implicating
mesiotemporal
lobe
(MTL)
regions
such
as
the
hippocampus
distributed
neocortices.
Here,
we
explored
declarative
system
reorganization
in
patients
unilateral
temporal
epilepsy
(TLE)
a
human
disease
model
to
test
impact
variable
degrees
MTL
pathology
on
function.
Our
cohort
included
31
TLE
60
age-
sex-matched
healthy
controls,
all
participants
underwent
retrieval
tasks
during
multimodal
MRI
session.
The
were
closely
matched
terms
stimuli
trial
design.
Capitalizing
non-linear
connectome
gradient-mapping
techniques,
derived
task-based
topographies
states,
neocortical
networks.
Comparing
hippocampal
gradients
between
observed
marked
topographic
systems
states.
Neocortical
alterations
characterized
by
reduced
differentiation
across
lateral
midline
parietal
cortices
hemispheres.
In
MTL,
contrast,
presented
more
posterior
anterior
segments
ipsilateral
seizure
focus
pathological
core,
indicating
perturbed
intrahippocampal
connectivity.
Semantic
was
also
found
bilateral
angular
regions,
unaffected.
Furthermore,
leveraging
proxies
pathology,
microstructure
morphology
that
associated
TLE-related
memory.
Moreover,
correlation
analysis
statistical
mediation
models
these
contributed
behavioural
deficits
memory,
but
again
not
patients.
Altogether,
our
findings
suggest
processes
rely
networks,
are
supported
network
involving
neocortex.
Alterations
networks
can
provide
compact
signature
state-dependent
conditions
damage,
TLE.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 29, 2023
A
bstract
Declarative
memory
encompasses
episodic
and
semantic
divisions.
Episodic
captures
singular
events
with
specific
spatiotemporal
relationships,
while
houses
context-independent
knowledge.
Behavioral
functional
neuroimaging
studies
have
revealed
common
distinct
neural
substrates
of
both
systems,
implicating
mesiotemporal
lobe
(MTL)
regions
distributed
neocortices.
Here,
we
studied
a
population
patients
unilateral
temporal
epilepsy
(TLE)
variable
degrees
MTL
pathology
as
human
disease
model
to
explore
declarative
system
reorganization,
examine
neurocognitive
associations.
Our
cohort
included
20
TLE
well
60
age
sex-matched
healthy
controls,
who
underwent
retrieval
tasks
during
MRI
session.
Tasks
were
closely
matched
in
terms
stimuli
trial
design.
Capitalizing
on
connectome
gradient
mapping
techniques,
derived
task-based
topographies
states,
the
neocortical
networks.
Comparing
hippocampal
gradients
between
observed
topographic
reorganization
but
not
characterized
by
marked
compression
lateral
midline
parietal
cortices
hemispheres,
cooccurring
an
expansion
anterior-posterior
differentiation
ipsilateral
pathology.
These
findings
suggest
that
processes
are
supported
network,
hippocampus
neocortex,
such
alterations
can
provide
compact
signature
state-dependent
conditions
associated
damage
TLE.
Leveraging
microstructural
morphological
proxies
pathology,
furthermore
pathological
markers
selective
TLE-related
reorganization.
Moreover,
correlation
analysis
statistical
mediation
models
these
contributed
behavioral
deficits
patients.
Altogether,
our
point
systems
TLE,
which
consistently
affects
deficits.
consistent
structure-function
relationships
reaffirm
critical
role
systems.
Discoveries
of
functional
cell
types,
exemplified
by
the
cataloging
spatial
cells
in
hippocampal
formation,
are
heralded
as
scientific
breakthroughs.
We
question
whether
identification
types
based
on
human
intuitions
has
merit
and
suggest
that
“spatial
cells”
may
arise
non-spatial
computations
sufficient
complexity.
show
deep
neural
networks
(DNNs)
for
object
recognition,
which
lack
grounding,
contain
numerous
units
resembling
place,
border,
head-direction
cells.
Strikingly,
even
untrained
DNNs
with
randomized
weights
contained
such
support
decoding
information.
Moreover,
when
these
“spatial”
excluded,
information
can
be
decoded
from
remaining
DNN
units,
highlights
superfluousness
to
cognition.
Now
large-scale
simulations
feasible,
complexity
brain
should
respected
intuitive
notions
type,
misleading
any
complex
network,
relegated
history.
