Опубликована: Янв. 1, 2024
Язык: Английский
Опубликована: Янв. 1, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159942 - 159942
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
How to accurately diagnose and treat bacterial infections in vivo remains a huge challenge. Therefore, we have developed targeted delivery nanosystem by coextruding the pretreated macrophage membrane of S. aureus with carbon dots (M@CD). The M@CD demonstrates potent antibacterial effects both vitro through generation reactive oxygen species (ROS). Furthermore, exhibits enhanced targeting ability stable fluorescence properties, addressing issues such as poor efficiency high immunogenicity vivo. This innovative approach enables infection site specific aggregation elimination infections, thereby providing promising strategy for integrated diagnosis, treatment, monitoring infections.
Язык: Английский
Процитировано
1Materials Today Bio, Год журнала: 2025, Номер 31, С. 101575 - 101575
Опубликована: Фев. 14, 2025
The innate immune system's inactivation and microbial biofilm-induced antibiotic resistance are the main causes of implant-associated infections (IAIs), which frequently result in implant surgical failure. Refractory recolonization is consequence standard therapies that unable to consistently suppress escaping planktonic bacteria from biofilm, thereby enabling IAIs thrive. Here, we specifically designed a macrophage-like biomimetic nanoparticle (F/R@PM) for biofilm microenvironment (BME), was fabricated by coating cell membrane derived macrophage onto poly (lactic-co-glycolic acid) (PLGA) namoparticles (NPs) loaded with FOT (NO donor) R837 (TLR7 agonist). After injecting F/R@PM into mice infections, it able selectively target macrophages through proteins on its surface effectively release R837. Then, spreads outside could react glutathione (GSH) BEM rapidly produce large amount NO inside biofilms destroy kill bacteria. At same time, would encourage scavenge had escaped disintegration improved phagocytosis. Overall, this work shows treatment immunotherapy together have promising potential long-term efficient control eradication IAIs.
Язык: Английский
Процитировано
1Pharmacological Research, Год журнала: 2023, Номер 199, С. 107022 - 107022
Опубликована: Дек. 1, 2023
Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches
Язык: Английский
Процитировано
19Advanced Materials, Год журнала: 2024, Номер 36(38)
Опубликована: Июль 30, 2024
Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. However, poor stability and off-target effects during in vivo transportation hinder their practical clinical applications. Precision delivery adaptive release of siRNAs into inflamed tissues immune cells could unleash full therapeutic potential. This study establishes a pyroptotic-spatiotemporally selective siRNA system (PMRC@siGSDME) that selectively targets inflammatory tissues, responds to pyroptosis, exhibits remarkable efficacy against various Novel hybrid nanovesicles (NVs) are designed as combination pyroptotic macrophage membranes (PMs) R8-cardiolipin-containing (RC-NVs). Evidence provides PM-derived proteins involved cell-cell interactions membrane trafficking may contribute the specificity NVs tissue. In addition, cardiolipin anchored increases its affinity activated gasdermin E (GSDME) achieves pyroptosis-adaptive siGSDME spatiotemporally suppression responses. More importantly, PMRC@siGSDME displays significant anti-inflammatory multiple mouse disease models, including arthritis bowel (IBD). Collectively, an innovative strategy precisely tailored has been developed, paving way new treatments diseases with minimal side wide applicability.
Язык: Английский
Процитировано
5Current Opinion in Biotechnology, Год журнала: 2023, Номер 84, С. 103013 - 103013
Опубликована: Окт. 26, 2023
Язык: Английский
Процитировано
12Advanced Materials, Год журнала: 2023, Номер 36(11)
Опубликована: Дек. 14, 2023
Metallo-β-lactamases (MBLs) represent a prevalent resistance mechanism in Gram-negative bacteria, rendering last-line carbapenem-related antibiotics ineffective. Here, bioresponsive sliver peroxide (Ag
Язык: Английский
Процитировано
12Biomaterials, Год журнала: 2023, Номер 305, С. 122453 - 122453
Опубликована: Дек. 24, 2023
Язык: Английский
Процитировано
11Talanta, Год журнала: 2024, Номер 271, С. 125630 - 125630
Опубликована: Янв. 6, 2024
Язык: Английский
Процитировано
4Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)
Опубликована: Март 26, 2024
Abstract Volumetric muscle loss (VML) is a severe form of trauma that exceeds the regenerative capacity skeletal tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder regeneration following VML. Here, an interfacial cross‐linked hydrogel‐poly(ε‐caprolactone) nanofiber composite, incorporates both biophysical biochemical cues modulate ROS microenvironment for enhanced VML repair, engineered. cross‐linking achieved through Michael addition between catechol thiol groups. resultant composite exhibits mechanical strength without sacrificing porosity. Moreover, it mitigates oxidative stress promotes macrophage polarization toward pro‐regenerative phenotype, in vitro mouse model. 4 weeks post‐implantation, mice implanted with show improved grip walking performance, along increased fiber diameter, angiogenesis, more nerve innervation compared control mice. Collectively, these results suggest nanofiber‐hydrogel could serve as cell‐free drug‐free strategy augmenting by modulating at site.
Язык: Английский
Процитировано
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