Neutrophil-mediated cordycepin-based nanoparticles for targeted treatment of acute lung injury

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159942 - 159942

Опубликована: Янв. 1, 2025

Язык: Английский

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Macrophage Membrane-Encapsulated Carbon Dots for Precise Targeting Diagnosis and Treatment of Bacterial Infections

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

How to accurately diagnose and treat bacterial infections in vivo remains a huge challenge. Therefore, we have developed targeted delivery nanosystem by coextruding the pretreated macrophage membrane of S. aureus with carbon dots (M@CD). The M@CD demonstrates potent antibacterial effects both vitro through generation reactive oxygen species (ROS). Furthermore, exhibits enhanced targeting ability stable fluorescence properties, addressing issues such as poor efficiency high immunogenicity vivo. This innovative approach enables infection site specific aggregation elimination infections, thereby providing promising strategy for integrated diagnosis, treatment, monitoring infections.

Язык: Английский

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A macrophage-like biomimetic nanoparticle with high-efficiency biofilm disruption and innate immunity activation for implant-related infection therapy

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101575 - 101575

Опубликована: Фев. 14, 2025

The innate immune system's inactivation and microbial biofilm-induced antibiotic resistance are the main causes of implant-associated infections (IAIs), which frequently result in implant surgical failure. Refractory recolonization is consequence standard therapies that unable to consistently suppress escaping planktonic bacteria from biofilm, thereby enabling IAIs thrive. Here, we specifically designed a macrophage-like biomimetic nanoparticle (F/R@PM) for biofilm microenvironment (BME), was fabricated by coating cell membrane derived macrophage onto poly (lactic-co-glycolic acid) (PLGA) namoparticles (NPs) loaded with FOT (NO donor) R837 (TLR7 agonist). After injecting F/R@PM into mice infections, it able selectively target macrophages through proteins on its surface effectively release R837. Then, spreads outside could react glutathione (GSH) BEM rapidly produce large amount NO inside biofilms destroy kill bacteria. At same time, would encourage scavenge had escaped disintegration improved phagocytosis. Overall, this work shows treatment immunotherapy together have promising potential long-term efficient control eradication IAIs.

Язык: Английский

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Macrophage-related therapeutic strategies: Regulation of phenotypic switching and construction of drug delivery systems

Pharmacological Research, Год журнала: 2023, Номер 199, С. 107022 - 107022

Опубликована: Дек. 1, 2023

Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches

Язык: Английский

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Pyroptotic‐Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases

Advanced Materials, Год журнала: 2024, Номер 36(38)

Опубликована: Июль 30, 2024

Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. However, poor stability and off-target effects during in vivo transportation hinder their practical clinical applications. Precision delivery adaptive release of siRNAs into inflamed tissues immune cells could unleash full therapeutic potential. This study establishes a pyroptotic-spatiotemporally selective siRNA system (PMRC@siGSDME) that selectively targets inflammatory tissues, responds to pyroptosis, exhibits remarkable efficacy against various Novel hybrid nanovesicles (NVs) are designed as combination pyroptotic macrophage membranes (PMs) R8-cardiolipin-containing (RC-NVs). Evidence provides PM-derived proteins involved cell-cell interactions membrane trafficking may contribute the specificity NVs tissue. In addition, cardiolipin anchored increases its affinity activated gasdermin E (GSDME) achieves pyroptosis-adaptive siGSDME spatiotemporally suppression responses. More importantly, PMRC@siGSDME displays significant anti-inflammatory multiple mouse disease models, including arthritis bowel (IBD). Collectively, an innovative strategy precisely tailored has been developed, paving way new treatments diseases with minimal side wide applicability.

Язык: Английский

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Cell–nano interactions of polydopamine nanoparticles

Current Opinion in Biotechnology, Год журнала: 2023, Номер 84, С. 103013 - 103013

Опубликована: Окт. 26, 2023

Язык: Английский

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Bio‐Responsive Sliver Peroxide‐Nanocarrier Serves as Broad‐Spectrum Metallo‐β‐lactamase Inhibitor for Combating Severe Pneumonia

Advanced Materials, Год журнала: 2023, Номер 36(11)

Опубликована: Дек. 14, 2023

Metallo-β-lactamases (MBLs) represent a prevalent resistance mechanism in Gram-negative bacteria, rendering last-line carbapenem-related antibiotics ineffective. Here, bioresponsive sliver peroxide (Ag

Язык: Английский

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Dual-crosslinking immunostimulatory hydrogel synchronously suppresses pancreatic fistula and pancreatic cancer relapse post-resection

Biomaterials, Год журнала: 2023, Номер 305, С. 122453 - 122453

Опубликована: Дек. 24, 2023

Язык: Английский

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Immune-like sandwich multiple hotspots SERS biosensor for ultrasensitive detection of NDKA biomarker in serum

Talanta, Год журнала: 2024, Номер 271, С. 125630 - 125630

Опубликована: Янв. 6, 2024

Язык: Английский

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Bioactive Nanofiber‐Hydrogel Composite Regulates Regenerative Microenvironment for Skeletal Muscle Regeneration after Volumetric Muscle Loss

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)

Опубликована: Март 26, 2024

Abstract Volumetric muscle loss (VML) is a severe form of trauma that exceeds the regenerative capacity skeletal tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder regeneration following VML. Here, an interfacial cross‐linked hydrogel‐poly(ε‐caprolactone) nanofiber composite, incorporates both biophysical biochemical cues modulate ROS microenvironment for enhanced VML repair, engineered. cross‐linking achieved through Michael addition between catechol thiol groups. resultant composite exhibits mechanical strength without sacrificing porosity. Moreover, it mitigates oxidative stress promotes macrophage polarization toward pro‐regenerative phenotype, in vitro mouse model. 4 weeks post‐implantation, mice implanted with show improved grip walking performance, along increased fiber diameter, angiogenesis, more nerve innervation compared control mice. Collectively, these results suggest nanofiber‐hydrogel could serve as cell‐free drug‐free strategy augmenting by modulating at site.

Язык: Английский

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