Effects of chronic light cycle disruption during adolescence on circadian clock, neuronal activity rhythms, and behavior in mice

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 17, 2024

The advent of artificial lighting, particularly during the evening and night, has significantly altered predictable daily light dark cycles in recent times. Altered environments disrupt biological clock negatively impact mood cognition. Although adolescents commonly experience chronic changes light/dark cycles, our understanding how adolescents’ brain adapts to remains limited. Here, we investigated cycle disruption (LCD) adolescence, exposing adolescent mice 19 h 5 darkness for days 12 L:12D 2 per week (LCD group) 4 weeks. We showed that LCD exposure did not affect circadian locomotor activity but impaired memory increased avoidance response mice. Clock gene expression neuronal rhythms analysis revealed disrupted local molecular dentate gyrus (DG) medial amygdala (MeA) pacemaker (SCN). In addition, characterized photoresponsiveness MeA somatostatin neurons are affected by acute aberrant adolescence. Our research provides new evidence highlighting potential consequences pubertal development on physiology behaviors.

Язык: Английский

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Turn off that night light! Light-at-night as a stressor for adolescents

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июль 31, 2024

Light-at-night is known to produce a wide variety of behavioral outcomes including promoting anxiety, depression, hyperactivity, abnormal sociability, and learning memory deficits. Unfortunately, we all live in 24-h society where people are exposed light-at-night or light pollution through night-shift work - the need for all-hours emergency services as well building street-lights, making exposure practically unavoidable. Additionally, increase screentime (tvs smart devices) during night also contributes poorer sleep impairments. Compounding these factors fact that adolescents tend be "night owls" prefer an evening chronotype compared younger children adults, so teenagers will have higher likelihood being light-at-night. Making matters worse prevalence high-school start times 8 am earlier combination too early school times, night, preference chronotypes recipe reduced sleep, which can contribute increased susceptibility issues this population. As such, mini-review show, using both human rodent model studies, how affects stress responses, connecting photic signaling circadian timing system hypothalamic-pituitary adrenal axis. review demonstrate more likely exhibit behavior response due changes development hormone regulation time period, discuss potential interventions help mitigate negative effects.

Язык: Английский

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Blue light-driven cell cycle arrest in thyroid cancer via Retinal-OPN3 complex

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 1, 2024

Papillary thyroid carcinoma (PTC) is the most common type of malignancy, with a rising incidence. Traditional treatments, such as thyroidectomy and radiotherapy, often lead to significant side effects, including impaired function. Therefore, there an urgent need for non-invasive therapeutic approaches. This study aims explore potential photobiomodulation therapy (PBMT), treatment using specific wavelengths light, in management PTC.

Язык: Английский

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Exposure to light supresses the activity of the medial and superior amygdala during emotional processing

Опубликована: Апрель 28, 2024

Abstract Background Light can influence several non-image-forming biological effects including the modulation of mood and emotional processing through neural circuitry that remains to be fully established. Rodent data showed nuclei amygdala, known important regulation processing, receive direct inputs from retina mediate part affective impact light. Here, we wanted assess whether these animal findings translate human beings. We determine dynamics light exposure on activity varied across its volume, during stimulation. Methods used 7 Tesla functional magnetic resonance imaging variations in illuminance regional amygdala healthy young adults (N = 29; 18 women; 24 ± 3.1y) an auditory task. Results find subregions medial nucleus receives retinal projection, a marked linear reduction with increasing when emotionally charged stimuli. Conclusion speculate it is affects state individuals. These shed more mechanisms underlie brain may contribute benefits therapy treatment disorders.

Язык: Английский

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Adjunctive clozapine with bright light mitigates cognitive deficits by synaptic plasticity and neurogenesis in sub-chronic MK-801 treated mice

Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 243, С. 173821 - 173821

Опубликована: Июль 11, 2024

Язык: Английский

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Engineering the Physical Microenvironment into Neural Organoids for Neurogenesis and Neurodevelopment

Small, Год журнала: 2023, Номер 20(6)

Опубликована: Сен. 28, 2023

Abstract Understanding the signals from physical microenvironment is critical for deciphering processes of neurogenesis and neurodevelopment. The discovery how surrounding shape human developing neurons hindered by bottleneck conventional cell culture animal models. Notwithstanding neural organoids provide a promising platform recapitulating neurodevelopment, building neuronal that accurately mimics native neurophysical features largely ignored in current organoid technologies. Here, it discussed modulates events during periods such as stem fates, tube closure, migration, axonal guidance, optic cup formation, cortical folding. Although models are widely used to investigate impacts factors on neurodevelopment neuropathy, important roles cell‐derived this field particularly highlighted. Considering great promise organoids, microenvironments with mechanical forces, electrophysiological microsystems, light manipulation will help fully understand cues neurodevelopmental processes. Neural combined cutting‐edge techniques, advanced atomic force microscopes, microrobots, structural color biomaterials might promote development organoid‐based research neuroscience.

Язык: Английский

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NSC689857, an inhibitor of Skp2, produces antidepressant-like effects in mice

Behavioural Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Апрель 23, 2024

We have previously reported that two inhibitors of an E3 ligase S-phase kinase-associated protein 2 (Skp2), SMIP004 and C1, antidepressant-like effect in non-stressed chronically stressed mice. This prompted us to ask whether other Skp2 could also antidepressant effect. Here, we used NSC689857, another inhibitor, investigate this hypothesis. The results showed administration NSC689857 (5 mg/kg) produced a time-dependent manner male mice, which started 8 days after drug administration. Dose-dependent analysis 5 10 mg/kg, but not 1 effects both female Administration induced mice when administered three times within 24 h (24, 5, before testing) acutely (1 testing). In addition, fluoxetine coadministration additive These were associated with the changes locomotor activity. attenuated depression-like behaviors by chronic social defeat stress, suggesting therapeutic potential depression. Overall, these suggest is capable exerting

Язык: Английский

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Disruption of the Circadian Rhythm Is Exacerbated by Aging and Ameliorated by Time- restricted Feeding

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 20, 2024

Background: Circadian rhythms exist across species, and circadian rhythm disorder (CRD) occurs in people of all ages is prevalent those with age-related neurodegenerative diseases. The gut microbiota changes age a significant proportion microbes show their homeostasis. Dysregulation microbial homeostasis likewise disease trigger. Results: In this study, to investigate the relationship between aging, CRD, microbes, we created model CRD by controlling light/dark cycle, found that aging aggravated cognitive impairment mood disorders. This was accompanied loss homeostasis, intestinal barrier, systemic inflammation aged mice CRD. abnormal expression pattern genes underpin ifi27l2, thereby exacerbating oxidative stress. In addition, time-restricted feeding (TRF) ameliorated negative effects enriching Akkermansia_muciniphilaand inhibiting NOD-like signaling pathway. Conclusion: Aged more severe impairments response stress, likely due from gene dysregulation. Maintaining regular eating schedule can help reduce these effects.

Язык: Английский

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Operant Light Seeking in Mice: A Potential Model for Behavioral Disorders

Опубликована: Июль 29, 2024

Smartphone (over)use and internet use disorders share some features with substance behavioral addictions. From the associative learning perspective, these characteristics include excessive unregulated self-administration of sensory reinforcement on a digital operandum, possibly reflecting transition from goal-directed actions (action → outcome associations) to habitual responses (stimulus response associations). In laboratory mice, light stimulation at an optimal intensity possesses reinforcing properties brief pulse represents effective reinforcer for persistent operant responding. Here we propose that mouse seeking paradigm clearly defined reinforcers schedules may be utilized elucidate neurobiology symptoms emerging technology-based disorders.

Язык: Английский

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Specific retinal neurons regulate context-dependent defensive responses to visual threat

PNAS Nexus, Год журнала: 2024, Номер 3(10)

Опубликована: Сен. 24, 2024

Abstract While encountering a visual threat, an animal assesses multiple factors to choose appropriate defensive strategy. For example, when rodent detects looming aerial predator, its behavioral response can be influenced by specific environmental context, such as the availability of shelter. Indeed, rodents typically escape from stimulus shelter is present; otherwise, they freeze. Here we report that context-dependent responses initiated at earliest stage system distinct types retinal ganglion cells (RGCs), retina's output neurons. Using genetically defined cell ablation in mature mice, discovered some RGC were necessary for either escaping (alpha RGCs) or freezing (intrinsically photosensitive but not both behaviors; whereas other required behavior (direction-selective RGCs preferring vertical motion). Altogether, our results suggest regulate elicited same threatening depending on contextual signals environment. These findings emphasize unique contribution early pathways evolutionally conserved reactions.

Язык: Английский

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