Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers DOI Creative Commons
Shai Sabbah,

Elyashiv Zangen,

Shira Hadar

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Авг. 17, 2023

Abstract While light can affect emotional and cognitive processes of the medial prefrontal cortex (mPFC), no light-encoding was hitherto identified in this region. Here, extracellular recordings awake mice revealed that over half studied mPFC neurons showed photosensitivity, diminished by chemogenetic inhibition intrinsically photosensitive retinal ganglion cells (ipRGCs), or upstream thalamic perihabenular nucleus (PHb). In 15% neurons, firing rate changed monotonically along light-intensity steps gradients. These light-intensity-encoding comprised four types, two enhancing suppressing their with increased intensity. types were also PHb, where they exhibited shorter latency sensitivity. Light suppressed prelimbic activity but boosted infralimbic activity, mirroring contrasting roles fear-conditioning, drug-seeking, anxiety. We posit photosensitivity represents a substrate light-susceptible, mPFC-mediated functions, which could as therapeutical target psychiatric addiction disorders.

Язык: Английский

Light-eye-body axis: exploring the network from retinal illumination to systemic regulation DOI Creative Commons
Yi Zeng, Rong Rong,

Mengling You

и другие.

Theranostics, Год журнала: 2024, Номер 15(4), С. 1496 - 1523

Опубликована: Дек. 31, 2024

The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. eye, as a primary organ for information acquisition, not only plays crucial role in visual perception but also, increasing evidence suggests, exerts broad influence on the entire through circuits upon receiving light signals which called non-image-forming vision. However, extent mechanisms of light's impact eyes remain insufficiently explored. There also dearth comprehensive reviews elucidating interplay between light, systemic connections to body. Herein, we propose concept light-eye-body axis systematically encapsulate extensive effects received by retina We reviewed visual-neural structure basis axis, summarized mechanism regulate whole current research status challenges within pathological processes involved axis. Future should aim expand explore its deeper mechanisms. Understanding investigating will contribute improving lighting conditions optimize health guide establishment phototherapy standards clinical practice.

Язык: Английский

Процитировано

0
Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers DOI Creative Commons
Shai Sabbah,

Elyashiv Zangen,

Shira Hadar

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Авг. 17, 2023

Abstract While light can affect emotional and cognitive processes of the medial prefrontal cortex (mPFC), no light-encoding was hitherto identified in this region. Here, extracellular recordings awake mice revealed that over half studied mPFC neurons showed photosensitivity, diminished by chemogenetic inhibition intrinsically photosensitive retinal ganglion cells (ipRGCs), or upstream thalamic perihabenular nucleus (PHb). In 15% neurons, firing rate changed monotonically along light-intensity steps gradients. These light-intensity-encoding comprised four types, two enhancing suppressing their with increased intensity. types were also PHb, where they exhibited shorter latency sensitivity. Light suppressed prelimbic activity but boosted infralimbic activity, mirroring contrasting roles fear-conditioning, drug-seeking, anxiety. We posit photosensitivity represents a substrate light-susceptible, mPFC-mediated functions, which could as therapeutical target psychiatric addiction disorders.

Язык: Английский

Процитировано

0