Long-term ambient ozone exposure and incident cardiovascular diseases: National cohort evidence in China

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134158 - 134158

Опубликована: Март 30, 2024

Язык: Английский

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Cross‐tissue comparison of epigenetic aging clocks in humans

Aging Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Epigenetic clocks are a common group of tools used to measure biological aging—the progressive deterioration cells, tissues, and organs. have been trained almost exclusively using blood‐based but there is growing interest in estimating epigenetic age less‐invasive oral‐based tissues (i.e., buccal or saliva) both research commercial settings. However, differentiated cell types across body exhibit unique DNA methylation landscapes age‐related alterations the methylome. Applying derived from estimate may introduce biases. We tested within‐person comparability five tissue types: epithelial, saliva, dry blood spots, buffy coat leukocytes), peripheral mononuclear cells. 284 distinct samples 83 individuals aged 9–70 years. Overall, were significant differences clock estimates versus with average 30 years observed some clocks. In addition, most exhibited low correlation despite controlling for cellular proportions other technical factors. Notably, Skin Blood greatest concordance all types, indicating its ability chronological oral‐ tissues. Our findings indicate that application blood‐derived not yield comparable age, highlighting need careful consideration type when age.

Язык: Английский

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To promote healthy aging, focus on the environment

Nature Aging, Год журнала: 2023, Номер 3(11), С. 1334 - 1344

Опубликована: Ноя. 9, 2023

Язык: Английский

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Improving the green space arrangement in residential areas from the perspective of tree leaf temperature utilizing scenario simulation in ENVI-met

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170650 - 170650

Опубликована: Фев. 4, 2024

Язык: Английский

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Urology on a changing planet: links between climate change and urological disease

Nature Reviews Urology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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A Dynamic Assessment for Greenness Exposure and Socioeconomic Drivers: Evidence from 314 Chinese Cities (2000-2020)

Urban forestry & urban greening, Год журнала: 2025, Номер unknown, С. 128717 - 128717

Опубликована: Фев. 1, 2025

Язык: Английский

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Linked emergence of racial disparities in mental health and epigenetic biological aging across childhood and adolescence

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

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Associations of Urban Blue and Green Spaces With Coronary Artery Calcification in Black Individuals and Disadvantaged Neighborhoods

Circulation, Год журнала: 2024, Номер 150(3), С. 203 - 214

Опубликована: Июнь 27, 2024

Proximity to urban blue and green spaces has been associated with improved cardiovascular health; however, few studies have examined the role of race socioeconomic status in these associations.

Язык: Английский

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Greater residential greenness is associated with reduced epigenetic aging in adults

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 28, 2025

Abstract Potential pathways linking urban green spaces to improved health include relaxation, stress alleviation, and immune system functioning. Epigenetic age acceleration (EAA) is a composite biomarker of biological aging based on DNA methylation measurements; it predictive morbidity mortality. This cross-sectional study 116 adult residents metropolitan area in central North Carolina investigated associations between exposure residential EAA using four previously developed epigenetic formulas. tests white blood cells were conducted Illumina MethylationEPIC v1.0 assays. values calculated as residuals from the linear regression model chronological age. Residential greenness was characterized tree cover, total vegetated land normalized difference vegetation index (NDVI) data. An interquartile range (IQR) increase distance-to-residence weighted average within 500 m residence consistently associated with reduced adjusted for sociodemographic covariates, smoking status, cell fractions, two-dimensional spline function geographic coordinates. The reduction estimates measures ranged − 1.0 1.6 years 1.2 1.5 0.9 1.3 NDVI; 11 12 statistically significant ( p < 0.05). produced new evidence greater near residences.

Язык: Английский

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Mediation of Social Determinants and Hypertension by Epigenetic Age in CARDIA

Hypertension, Год журнала: 2025, Номер 82(3)

Опубликована: Фев. 19, 2025

Язык: Английский

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