Molecular Microbiology, Год журнала: 2023, Номер 120(6), С. 906 - 909
Опубликована: Ноя. 16, 2023
The UK Cellular Microbiology Network Meeting started in 2019 with the vision of supporting and enhancing cellular microbiology community Europe. Since its inception, network meeting has emerged as an important platform for infection cell biologists to inspire transformative collaborations novel research agendas. is highly interactive focused on promoting early career researchers discovery science. fifth this series was held 19–20 June 2023 at iconic London School Hygiene & Tropical Medicine (LSHTM). Similar 2022 event Warwick (https://onlinelibrary.wiley.com/do/10.1111/mmi.0040011), spread over 2 days so that participants could maximise dynamic science downtown location. To represent ethos our community, invited speakers were Pascale Cossart (from Institut Pasteur Paris, France) Felix Randow MRC LMB Cambridge, UK). We also had a strong cohort from across Europe who presented their work (Figure 1). Following coffee welcoming remarks Serge Mostowy (LSHTM), opened keynote talk by entitled ‘How give birth star’, showcasing rise Listeria paradigm (Cossart, 2023) her decorated which recently celebrated two joined Molecular Special Issues (Buchrieser, 2020; Pizarro-Cerda, 2020). talked about career-spanning body work, including ActA actin-based motility, generation first humanised mouse model study invasion, uncovering numerous mechanisms underlying bacterial virulence. All inspired hear enthusiasm science, moving forward. Although field blooming more than ever, she advised future generations need think context evolution environment—in other words, it happening. session chaired (LSHTM) Dan Humphreys (Sheffield). Giulia Manigrasso Andrew Carter's lab, LMB) Orientia tsutsugamushi (in collaboration Jeanne Salje's CIMR) how obligate intracellular pathogen hijacks dynein motility transport autophagy evasion. next Samkeliso Lisa Blundell David Holden's Imperial College London), describing Salmonella effector SteD co-activator E3 ubiquitin ligase WWP2. last Miguel Hernandez-Gonzalez Michael Way's Francis Crick), imaging poxvirus assembly exit infected cells using state-of-the-art microscopy techniques, cryo-electron tomography (Hernandez-Gonzalez et al., 2023). Phil Elks (Sheffield) began Margarida Gomes Mostowy's LSHTM), zebrafish models decipher trained innate immunity guide vaccine studies against shigellosis (Gomes Next Thomas Burgess Elks' Sheffield) models, aiming boost immune response fungal Candida albicans via modulation hypoxia-inducible factor (HIF). Guy Pearson Jeremy Carlton's Crick Kings highlighting wide variety advanced technologies he described envelope SARS-CoV-2 (the causative agent COVID) trafficking pathway deacidify lysosomes. This followed flash talks selected submitted abstracts researchers. Gizem Ozbaykal-Guler LSHTM) interdisciplinary testing role septin hetero-oligomer composition cage entrapment Shigella. Keith Egger Charlotte Odendall's London) discussed Type III Secretion System (T3SS) SPI-2 effectors inhibition interferon signalling. Ines Diaz del Olmo Teresa Thurston's promote non-canonical reprogramming transcriptional pathways; Shan Yin James Mason's symbioses between vaginosis-associated bacteria lactobacilli. Daniel Stark Jason King's reported endosymbionts host-Mucorales interactions. Stevens Robertin his Staphylococcus aureus interactions Gram-positive pathogens. Finally, Richard Allen Meera Unnikrishnan's Warwick) S. interacts macrophages VII (T7SS). late evening ended drinks, poster electric discussion. following morning Odendall (Kings London). second speaker, Randow, delivered thought-provoking defend cytosol invasive bacteria, revealing unexpected roles RNF213 cell-autonomous (Otten 2021). Magdalena Szczesna cytosolic inhibit RNF213-mediated (Szczesna Next, Miriam Kutsch, new group leader Heinrich Heine University (Germany), guanylate binding proteins (GBPs) activate inflammasome. showcased local excellence. Lucy Thorne Greg Towers' lab convergent variants concern enhance suppression (Thorne 2022). Ann-Kathrin Reuschl Clare Jolly's enhanced evasion Omicron subvariants (Mesner In set talks, Ramon Garcia Maset Jennifer Rohn's urinary microenvironment biofilm effect antibiotic uropathogens. Janis Romanopulos into translation pleurocidin-derived antimicrobial peptide therapeutics. Ioanna Panagi molecular dissection kinase effectors. Yizhou Huang analysing antibacterial during Burkholderia. Nagisa Yoshida Naomi McGovern's Cambridge) revealed tools microbicidal capacity human placental gestation. Zoe Speirs efforts modulate therapeutic strategy tuberculosis. presentations networking, lunch coffee. final Rohn (University Enrica Pellegrino Max Gutierrez's Crick) innovative peroxisomes M. tuberculosis (Pellegrino Kathryn Wright Stefan Oehlers' Centenary Institute Australia) discovered, infection, mycobacterial infection-induced miR-126 protects host suppressing permissive (Wright J.J. Awodipe transcriptomic responses osteoblasts infection. speaker afternoon Foulkes Stephen Kaye's Liverpool) exotoxin inhibitors therapeutics, drug pipeline vitro vivo analysis. closed robust discussion prize giving, snacks. won best oral presentation Orientia, Salmonella. Find out respective interviews published alongside report (Ines, 2023; Manigrasso, are very thankful flagship sponsor Company Biologists talented been since edition 2). grateful LSHTM helping coordinate event. Mostowy: Conceptualization; writing – original draft; review editing. Odendall: Humphreys: Philip Elks: L. Rohn: authors declare no conflict interest. No or animal subjects materials used commentary. Data sharing not applicable article data created analyzed study.
Язык: Английский
