Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus DOI Creative Commons
Hannah E. Stinson, Ipe Ninan

Heliyon, Год журнала: 2024, Номер 10(19), С. e38192 - e38192

Опубликована: Сен. 20, 2024

The ascending neuromodulatory pathway from the median raphe nucleus (MRN) extends widely throughout midline/para-midline regions and robustly innervates hippocampus. This is believed to be critical for regulating emotional affective behaviors. Although MRN primarily contains serotoninergic (5-HTergic), GABAergic, glutamatergic neurons, neurons expressing vesicular glutamate transporter 3 (VGLUT3) form primary input Despite earlier demonstration of robust VGLUT3 innervation hippocampus, little known about how this modulates synaptic transmission plasticity in Our studies show that activate serotonin 3a receptor (5-HT3aR)-expressing GABAergic including VGLUT3-expressing at stratum radiatum (SR)/stratum lacunosum moleculare (SLM) border. neuron-mediated onto SR/SLM 5-HT3aR negatively regulated by 5-HT through 5-HT1B receptors. In agreement with activation projections induces a long-lasting increase but not CA1 pyramidal male female mice. Consistent enhancement mice, suppresses Schaffer collateral (SC)-CA1 long-term potentiation (LTP) Thus, our results modulate dorsal hippocampus augmenting inhibition suppressing SC-CA1 LTP sex-specific manner.

Язык: Английский

GABAB receptor-mediated potentiation of ventral medial habenula glutamatergic transmission in GABAergic and glutamatergic interpeduncular nucleus neurons DOI Creative Commons
Hannah E. Stinson, Ipe Ninan

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract The medial habenula (MHb)-interpeduncular nucleus (IPN) pathway plays an important role in information transferring between the forebrain and midbrain. MHb-IPN has been implicated regulation of fear behavior nicotine addiction. synapses ventral MHb IPN show a unique property, i.e., enhancement synaptic transmission upon activation GABA B receptors. This receptor-mediated potentiation regulating memory. Although is known to contain parvalbumin (PV) somatostatin (SST) GABAergic neurons vesicular glutamate transporter 3 (VGLUT3)-expressing neurons, it unknown how receptor affects MHb-mediated glutamatergic onto these three subtypes neurons. Our studies robust connectivity from PV SST IPN, while VGLUT3 weak. receptors produces we observed modest effect Despite diminished basal causes transient conversion non-responding into active some Thus, our results strong compared VGLUT3-expressing Furthermore, differential on PV, SST, IPN.

Язык: Английский

Процитировано

0
Deciphering the Functions of Raphe–Hippocampal Serotonergic and Glutamatergic Circuits and their Deficits in Alzheimer’s Disease DOI Open Access
Wanting Yu, R Zhang,

Aosheng Zhang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1234 - 1234

Опубликована: Янв. 30, 2025

Subcortical innervation of the hippocampus by raphe nucleus is essential for emotional and cognitive control. The two major afferents from to originate serotonergic glutamatergic neurons, which control hippocampal inhibitory network, theta activity, synaptic plasticity have been extensively explored in growing body literature, whereas those circuits received little attention. Notably, both between are disrupted Alzheimer's disease (AD), may contribute initiation progression behavioral psychological symptoms dementia. Thus, deciphering mechanism underlying abnormal raphe-hippocampal AD crucial prevent dementia-associated symptoms. In this review, we summarize anatomical, neurochemical, electrophysiological diversity nuclei as well architecture circuitry. We then elucidate subcortical activity their role regulation emotion cognition. Additionally, present an overview pathogenesis analyze available therapies that can potentially be used clinically alleviate neuropsychiatric decline course.

Язык: Английский

Процитировано

0
Colocalization of Neurotransmitters in Hippocampus and Afferent Systems: Possible Functional Role DOI
Valentina Kitchigina

Biochemistry (Moscow), Год журнала: 2025, Номер 90(1), С. 61 - 78

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus DOI Creative Commons
Hannah E. Stinson, Ipe Ninan

Heliyon, Год журнала: 2024, Номер 10(19), С. e38192 - e38192

Опубликована: Сен. 20, 2024

The ascending neuromodulatory pathway from the median raphe nucleus (MRN) extends widely throughout midline/para-midline regions and robustly innervates hippocampus. This is believed to be critical for regulating emotional affective behaviors. Although MRN primarily contains serotoninergic (5-HTergic), GABAergic, glutamatergic neurons, neurons expressing vesicular glutamate transporter 3 (VGLUT3) form primary input Despite earlier demonstration of robust VGLUT3 innervation hippocampus, little known about how this modulates synaptic transmission plasticity in Our studies show that activate serotonin 3a receptor (5-HT3aR)-expressing GABAergic including VGLUT3-expressing at stratum radiatum (SR)/stratum lacunosum moleculare (SLM) border. neuron-mediated onto SR/SLM 5-HT3aR negatively regulated by 5-HT through 5-HT1B receptors. In agreement with activation projections induces a long-lasting increase but not CA1 pyramidal male female mice. Consistent enhancement mice, suppresses Schaffer collateral (SC)-CA1 long-term potentiation (LTP) Thus, our results modulate dorsal hippocampus augmenting inhibition suppressing SC-CA1 LTP sex-specific manner.

Язык: Английский

Процитировано

3