Thermoresponsive carboplatin-releasing prodrugs DOI Creative Commons

Aemilia D. McAdam,

Lucinda K. Batchelor,

Jan Romano-deGea

и другие.

Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 254, С. 112505 - 112505

Опубликована: Фев. 15, 2024

Platinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in treatment, however, clinically used platinum drugs have not been optimised for combination hyperthermia. The derivatisation of existing appropriately chosen thermoresponsive moieties results being activated only at the heated site. Perfluorinated chains varying lengths were installed on carboplatin, a approved drug, leading to successful synthesis series mono- di- substituted platinum(IV) carboplatin prodrugs. Some these complexes display relevant thermosensitivity ovarian cancer cell lines, i.e., inactive 37 °C having comparable activity under mild hyperthermia (42 °C). Nuclear magnetic resonance spectroscopy mass spectrometry indicated that likely active platinum(II) agent upon reduction cyclic voltammetry revealed length fluorinated alkyl chain has strong influence rate formation, regulating subsequent cytotoxicity.

Язык: Английский

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy DOI Creative Commons
Xuancheng Fu, Xiaoran Hu

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 2, 2024

Ultrasound has gained prominence in biomedical applications due to its noninvasive nature and ability penetrate deep tissue with spatial temporal resolution. The burgeoning field of ultrasound-responsive prodrug systems exploits the mechanical chemical effects ultrasonication for controlled activation prodrugs. In polymer mechanochemistry, materials scientists exploit sonomechanical effect acoustic cavitation mechanochemically activate force-sensitive On other hand, researchers sonodynamic therapy adopt fundamentally distinct methodologies, utilizing sonochemical (e.g., generation reactive oxygen species) ultrasound presence sonosensitizers induce transformations that This cross-disciplinary review comprehensively examines these two divergent yet interrelated approaches, both which originated from cavitation. It highlights molecular design strategies potential diverse therapeutic contexts, chemotherapy immunotherapy gene methods, discusses future directions this rapidly advancing domain.

Язык: Английский

Процитировано

7

Ultrasound-activated mechanochemical reactions for controllable biomedical applications DOI Creative Commons

Maocheng Zuo,

Rong Xiao,

Fangxue Du

и другие.

Smart Materials in Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

7

Biotin Receptor-Targeting PtIV Oxygen Carrying Prodrug Amphiphile for Alleviating Tumor Hypoxia Induced Immune Chemotherapy Suppression DOI

Kaichuang Sun,

Xiaodan Wei, Shangcong Han

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Platinum (Pt)-based chemotherapeutic agents, known for their potent cytotoxicity, are extensively used in clinical oncology. However, therapeutic efficacy is severely limited by a variety of factors, particularly the hypoxic tumor microenvironment (TME), which not only impedes effective drug delivery but also triggers immune suppression, further diminishing antitumor effects Pt drugs. In response to these challenges, we have developed biotin receptor (BR)-targeting oxaliplatin (OXA)-based PtIV prodrug, named Lipo-OPtIV-BT, could encapsulate hemoglobin (Hb) as an oxygen carrier, forming PtIV-loaded lipid nanoparticles (Hb@BTOPtIV). The design Hb@BTOPtIV aims address dual issues poor and suppression effectively increasing local tension TME. Notably, our findings demonstrate that cytotoxic BR-targeting prodrug increased levels synergistically reverse microenvironment, leading improved efficacy. We observed significantly biodistribution drug, enabling it preferentially accumulate regions. Importantly, enhanced oxygenation within TME plays critical role reshaping landscape tumor, promoting more favorable environment chemotherapy. This reversal evidenced infiltration T cells reduced regulatory (Tregs) tumor. These highlight promising potential using amphiphiles improve accumulation at sites counteract immunosuppression induced hypoxia.

Язык: Английский

Процитировано

1

Biological effects of metal-based nanomaterials for tumor metalloimmunotherapy DOI

Huali Lei,

Guanghui Hou,

Minjiang Chen

и другие.

Nano Today, Год журнала: 2023, Номер 53, С. 102033 - 102033

Опубликована: Окт. 31, 2023

Язык: Английский

Процитировано

17

Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges DOI
Qingqiang Min, Xingyue Ji

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(24), С. 16546 - 16567

Опубликована: Дек. 12, 2023

Time- and space-resolved drug delivery is highly demanded for cancer treatment, which, however, can barely be achieved with a traditional prodrug strategy. In recent years, the strategy based on bioorthogonal bond cleavage chemistry has emerged advantages of high temporospatial resolution over activation homogeneous irrespective individual heterogeneity. past five tremendous progress been witnessed in this field one such entering Phase II clinical trials. This Perspective aims to highlight these new advances (2019–2023) critically discuss their pros cons. addition, remaining challenges potential strategic directions future will also included.

Язык: Английский

Процитировано

14

Locally unlocks prodrugs by radiopharmaceutical in tumor for cancer therapy DOI

Changlun Wang,

Mengxin Xu, Zihang Zhang

и другие.

Science Bulletin, Год журнала: 2024, Номер 69(17), С. 2745 - 2755

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

6

Semiconducting polymer nanoprodrugs enable tumor-specific therapy via sono-activatable ferroptosis DOI

Fengshuo Wang,

Zhiting Wu,

Yijing Zhang

и другие.

Biomaterials, Год журнала: 2024, Номер 312, С. 122722 - 122722

Опубликована: Июль 29, 2024

Язык: Английский

Процитировано

6

Recent progress in stimuli‐activable metallo‐prodrugs for cancer therapy DOI Creative Commons
Jinzhe Liang,

Fangmian Wei,

Hui Chao

и другие.

Smart Molecules, Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Abstract The clinical approval of platinum‐based drugs has prompted the development novel metallo‐complexes during last several decades, while severe problems, especially for poor water solubility, drug resistance and toxicity in patients, greatly hindered trials curative efficacy. To address these issues, concept metallo‐prodrugs been proposed oncology. Some stimuli‐activable provide new insights designing preparing site‐specific prodrugs with maximized therapeutic efficacy negligible unfavorable by‐effects. In this review, recent progress past 20 years overviewed, where endogenous exogenous stimuli have involved. Typical examples smart are discussed regarding to their molecular structure, activation mechanism, promising biomedical applications. end, challenges future perspectives discussed.

Язык: Английский

Процитировано

6

Ultrasound‐Sensitive Targeted Liposomes as a Gene Delivery System for the Synergistic Treatment of Hepatocellular Carcinoma DOI

Guannan Wang,

Hongtong Lu,

Yong Pan

и другие.

Small, Год журнала: 2024, Номер 20(47)

Опубликована: Авг. 27, 2024

Gene therapy and sonodynamic therapy, as emerging treatment methods, have great potential in cancer treatment. However, there are significant challenges the vivo delivery of genes sonosensitizers during process, which ultimately affects therapeutic outcome. In this study, an ultrasound-sensitive targeted liposome nanoparticle system (MLip

Язык: Английский

Процитировано

5

Chemical and Photophysical Triggers for the Reduction of Pt(IV) Prodrugs for Anticancer Therapy DOI Creative Commons
Johannes Karges

ChemNanoMat, Год журнала: 2023, Номер 9(11)

Опубликована: Июль 18, 2023

Abstract Platinum(II) complexes are used in approximately 50% of chemotherapeutic treatments worldwide. Despite their undoubtful clinical success, these compounds associated with severe side effects and poor tumor selectivity. To overcome drawbacks, the development platinum(IV) molecular prodrugs nanoparticle formulations that remain stable therapeutically inactive a biological environment, but could be quickly reduced into active analogs through specific trigger have been thought. Within this article, mechanisms for chemical photophysical triggers activation critically reviewed.

Язык: Английский

Процитировано

11