Wound management materials and technologies from bench to bedside and beyond

Nature Reviews Materials, Год журнала: 2024, Номер 9(8), С. 550 - 566

Опубликована: Июнь 17, 2024

Язык: Английский

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Recent advances in biosensors for real time monitoring of pH, temperature, and oxygen in chronic wounds

Materials Today Bio, Год журнала: 2023, Номер 22, С. 100764 - 100764

Опубликована: Авг. 19, 2023

Chronic wounds are among the major healthcare issues affecting millions of people worldwide with high rates morbidity, losses limbs and mortality. Microbial infection in is a severe problem that can impede healing chronic wounds. Accurate, timely early detection infections, real time monitoring various wound biomarkers related to be significantly helpful treatment care However, clinical methodologies periodic assessment require physical visit clinics or hospitals time-consuming frequent replacement dressing patches, which also often adversely affect process. Besides, replacements dressings highly expensive, causing huge amount burden on national health systems. Smart bandages have emerged provide situ physiochemical surveillance at site. These integrate smart sensors detect condition based parameters, such as pH, temperature oxygen level reduces frequency changing its associated complications. devices continually monitor process, paving way for tailored therapy improved quality patient's life. In this review, we present an overview recent advances biosensors temperature, order assess status. We elaborated progress quantitative several important assessing status using biosensors. The review shows real-time by quantifying specific biomarkers, tissue oxygenation aid infected

Язык: Английский

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Self‐Sterilizing Microneedle Sensing Patches for Machine Learning‐Enabled Wound pH Visual Monitoring

Advanced Functional Materials, Год журнала: 2024, Номер 34(22)

Опубликована: Фев. 1, 2024

Abstract The skin, as the body's largest organ, is closely linked to an individual's health. Delayed diagnosis and treatment of skin infections can lead complications such non‐healing wounds sepsis. Despite significant, early identification wound timely remain a challenge that requires continuous management. This work presents novel strategy combines smart microneedle sensing inhibit infection track healing status. tip based on metal‐organic frameworks (MOF) hydrogel allows rapid self‐sterilization promotes healing. substrate patch pH–sensitive fluorescent reagents, integrate with smartphone visualize images. Furthermore, it be further reliably evaluated pH by applying machine‐learning algorithm. multifunctional establishes therapy address delayed management, design optimization MOF hydrogels, contributes facile way for disease personalized health

Язык: Английский

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Electronic Skin for Health Monitoring Systems: Properties, Functions, and Applications

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 17, 2024

Abstract Electronic skin (e‐skin), a skin‐like wearable electronic device, holds great promise in the fields of telemedicine and personalized healthcare because its good flexibility, biocompatibility, conformability, sensing performance. E‐skin can monitor various health indicators human body real time over long term, including physical (exercise, respiration, blood pressure, etc.) chemical (saliva, sweat, urine, etc.). In recent years, development materials, analysis, manufacturing technologies has promoted significant e‐skin, laying foundation for application next‐generation medical devices. Herein, properties required e‐skin monitoring devices to achieve long‐term precise summarize several detectable field are discussed. Subsequently, applications integrated systems reviewed. Finally, current challenges future directions this This review is expected generate interest inspiration improvement systems.

Язык: Английский

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Toward an AI Era: Advances in Electronic Skins

Chemical Reviews, Год журнала: 2024, Номер 124(17), С. 9899 - 9948

Опубликована: Авг. 28, 2024

Electronic skins (e-skins) have seen intense research and rapid development in the past two decades. To mimic capabilities of human skin, a multitude flexible/stretchable sensors that detect physiological environmental signals been designed integrated into functional systems. Recently, researchers increasingly deployed machine learning other artificial intelligence (AI) technologies to neural system for processing analysis sensory data collected by e-skins. Integrating AI has potential enable advanced applications robotics, healthcare, human–machine interfaces but also presents challenges such as diversity model robustness. In this review, we first summarize functions features e-skins, followed feature extraction different models. Next, discuss utilization design e-skin address key topic implementation e-skins accomplish range tasks. Subsequently, explore hardware-layer in-skin before concluding with an opportunities various aspects AI-enabled

Язык: Английский

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Applied body-fluid analysis by wearable devices

Nature, Год журнала: 2024, Номер 636(8041), С. 57 - 68

Опубликована: Дек. 4, 2024

Язык: Английский

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Injectable Hydrogels with Integrated Ph Probes and Ultrasound‐Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On‐Demand Treatment of Chronic Wounds

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(9)

Опубликована: Янв. 11, 2024

Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues adaptability challenges. In this study, an injectable hydrogel based smart dressing is developed by integrating food-derived anthocyanidin as a visual pH probe poly(L-lactic acid) microcapsules ultrasound-responsive delivery systems antibiotics poly(ethylene glycol) hydrogel. This straightforwardly prepared maintains its favorable properties repair, including porous morphology excellent biocompatibility. vitro experiments demonstrated that the enabled assessment within range 5 ∼ 9.Meanwhile, release could be triggered controlled ultrasound. vivo evaluations using infected wounds diabetic revealed effectively detected levels achieved antibacterial effects through ultrasound-triggered drug release. led to significantly enhanced healing, validated histological analysis measurement inflammatory cytokine levels. hydrogel-based holds great potential use in clinical settings inform timely intervention community improve care management.

Язык: Английский

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Empowerment of AI algorithms in biochemical sensors

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 173, С. 117613 - 117613

Опубликована: Фев. 29, 2024

Язык: Английский

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Multi-receptor skin with highly sensitive tele-perception somatosensory

Science Advances, Год журнала: 2024, Номер 10(37)

Опубликована: Сен. 11, 2024

The limitations and complexity of traditional noncontact sensors in terms sensitivity threshold settings pose great challenges to extend the five human senses. Here, we propose tele-perception enhance perception cognition beyond these conventional sensors. Our bionic multi-receptor skin employs structured doping inorganic nanoparticles local electric field, coupled with advanced deep learning algorithms, achieving a Δ V /Δ d 14.2, surpassing benchmarks. This enables precise remote control surveillance systems robotic manipulators. long short-term memory–based adaptive pulse identification achieves 99.56% accuracy material accelerated processing speeds. In addition, demonstrate feasibility using two-dimensional (2D) sensor matrix integrate real object scan data into convolutional neural network accurately discriminate shape 3D objects. promises transformative advances human-computer interaction neuromorphic computing.

Язык: Английский

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Smart sensors and wound dressings: Artificial intelligence-supported chronic skin monitoring – A review

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154371 - 154371

Опубликована: Июль 29, 2024

Язык: Английский

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