Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Abstract
Chemoresistance
and
metastasis
are
the
main
obstacles
to
clinical
success
of
anticancer
treatment
responsible
for
most
cancer
deaths.
Developing
effective
approaches
reverse
chemoresistance
inhibit
is
essential
efficient
chemotherapy.
Mitochondria
important
sources
cellular
energy
involved
in
mediating
driving
tumor
metastasis.
Due
relatively
weak
DNA
repair
capacity
mitochondria,
targeting
mitochondria
may
provide
a
paradigm
metastatic
treatment.
Herein,
exosomes
(Exos)
modified
with
integrin
ligands
mitochondriotropic
molecules
synthesized
encapsulating
oxaliplatin
(OXA)
construct
sequentially
targeted
mitochondrion‐dysfunctional
nanodrug
(OXA@Exo‐RD).
Subsequent
investigations
confirm
that
OXA@Exo‐RD
cells
sequence,
OXA
delivered
lacking
mechanisms
reduce
likelihood
deactivation.
Furthermore,
promotes
overproduction
ROS,
inhibited
ATP
generation,
induces
mitochondria‐mediated
apoptosis
mitochondrial
dysregulation.
Finally,
shows
potential
growth
HCT116/OXA
vitro,
which
further
validated
subcutaneous
orthotopic
CRC
models,
as
well
models.
Taken
together,
this
dual‐targeting
nanomedicine
via
signaling
pathways,
providing
an
attractive
strategy
drug‐resistant
CRC.
Advanced Materials,
Год журнала:
2024,
Номер
36(15)
Опубликована: Янв. 8, 2024
Abstract
The
inherent
immune
and
metabolic
tumor
microenvironment
(TME)
of
most
solid
tumors
adversely
affect
the
antitumor
efficacy
various
treatments,
which
is
an
urgent
issue
to
be
solved
in
clinical
cancer
therapy.
In
this
study,
a
mitochondrial
localized
situ
self‐assembly
system
constructed
remodel
TME
by
improving
immunogenicity
disrupting
plasticity
cells.
peptide‐based
drug
delivery
can
pre‐assembled
into
nanomicelles
vitro
form
functional
nanofibers
on
mitochondria
through
cascade‐responsive
process
involving
reductive
release,
targeted
enrichment,
self‐assembly.
organelle‐specific
self‐assemblyeffectively
switches
role
mitophagy
from
pro‐survival
pro‐death,
finally
induces
intense
endoplasmic
reticulum
stress
atypical
type
II
immunogenic
cell
death.
Disintegration
ultrastructure
also
impedes
cells,
greatly
promotes
immunosuppresive
remodeling
immunostimulatory
TME.
Ultimately,
effectively
suppresses
metastases,
converts
cold
hot
with
enhanced
sensitivity
radiotherapy
checkpoint
blockade
This
study
offers
universal
strategy
for
spatiotemporally
controlling
supramolecular
sub‐organelles
determine
fate
enhance
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(18), С. 9190 - 9253
Опубликована: Янв. 1, 2024
Autonomous
micro/nanorobots
capable
of
performing
programmed
missions
are
at
the
forefront
next-generation
micromachinery.
These
small
robotic
systems
predominantly
constructed
using
functional
components
sourced
from
micro-
and
nanoscale
materials;
therefore,
combining
them
with
various
advanced
materials
represents
a
pivotal
direction
toward
achieving
higher
level
intelligence
multifunctionality.
This
review
provides
comprehensive
overview
for
innovative
micro/nanorobotics,
focusing
on
five
families
that
have
witnessed
most
rapid
advancements
over
last
decade:
two-dimensional
materials,
metal-organic
frameworks,
semiconductors,
polymers,
biological
cells.
Their
unique
physicochemical,
mechanical,
optical,
properties
been
integrated
into
to
achieve
greater
maneuverability,
programmability,
intelligence,
multifunctionality
in
collective
behaviors.
The
design
fabrication
methods
hybrid
discussed
based
material
categories.
In
addition,
their
promising
potential
powering
motion
and/or
(multi-)functionality
is
described
fundamental
principles
underlying
explained.
Finally,
extensive
use
variety
applications,
including
environmental
remediation,
(bio)sensing,
therapeutics,
ACS Nano,
Год журнала:
2023,
Номер
17(14), С. 12971 - 12999
Опубликована: Июль 11, 2023
Swarms,
which
stem
from
collective
behaviors
among
individual
elements,
are
commonly
seen
in
nature.
Since
two
decades
ago,
scientists
have
been
attempting
to
understand
the
principles
of
natural
swarms
and
leverage
them
for
creating
artificial
swarms.
To
date,
underlying
physics;
techniques
actuation,
navigation,
control;
field-generation
systems;
a
research
community
now
place.
This
Review
reviews
fundamental
applications
micro/nanorobotic
The
generation
mechanisms
emergent
micro/nanoagents
identified
over
past
elucidated.
advantages
drawbacks
different
techniques,
existing
control
systems,
major
challenges,
potential
prospects
discussed.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 23, 2024
Swarm
behaviors
are
common
in
nature,
where
individual
organisms
collaborate
via
perception,
communication,
and
adaptation.
Emulating
these
dynamics,
large
groups
of
active
agents
can
self-organize
through
localized
interactions,
giving
rise
to
complex
swarm
behaviors,
which
exhibit
potential
for
applications
across
various
domains.
This
review
presents
a
comprehensive
summary
perspective
synthetic
swarms,
bridge
the
gap
between
microscale
swarms.
It
is
begun
by
examining
agents,
fundamental
units
understand
origins
their
motility
functionality
presence
external
stimuli.
Then
inter-agent
communications
agent-environment
that
contribute
generation
summarized.
Furthermore,
reported
date
emergence
machine
intelligence
within
reviewed.
Eventually,
enabled
distinct
swarms
By
discussing
emergent
insights
offered
into
design
deployment
autonomous
real-world
applications.
Inorganic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(5), С. 1339 - 1365
Опубликована: Янв. 1, 2024
The
review
covers
POMOF
materials
synthesis,
modification,
and
unique
properties,
focusing
on
biomedical
sensors
therapies.
Finally,
the
summarises
challenges
developments
of
POMOFs
in
biomedicine.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(15), С. 17151 - 17192
Опубликована: Июль 24, 2024
The
advancement
of
precision
medicine
in
modern
biomedicine
has
been
significantly
propelled
by
the
emergence
micro/nanorobots.
combination
micro/nanorobots
and
offers
unique
advantages
holds
attractive
potential
for
applications.
It
effectively
addresses
challenges
encountered
traditional
robots
areas
such
as
driving,
sensing,
intelligence
other
aspects,
especially
application
cancer
cardiovascular
diseases,
which
is
a
hot
field
interdisciplinary
research
recent
years.
This
review
succinctly
delineates
analyzes
advancements
First,
achievements
years
are
systematically
classified
introduced
from
four
perspectives:
manufacturing
design,
drive
control,
biomedical
degradation.
In
particular,
in-depth
discussions
were
conducted
regarding
solutions
each
stage.
Second,
based
on
latest
results
applications,
development
direction
industrial
applications
key
technical
aspects
that
need
to
be
paid
attention
emphasized.
Finally,
we
discuss
opportunities
future,
it
expected
will
become
more
sophisticated
capable
performing
multiple
medical
functions
tasks.
They
implemented
vivo
assist
doctors
diagnosing
treating
diseases.
shows
significant
medicine.
