PLoS Biology, Год журнала: 2024, Номер 22(8), С. e3002754 - e3002754
Опубликована: Авг. 15, 2024
Horizontal mitochondrial transfer (HMT) has emerged as a novel phenomenon in cell biology, but it is unclear how this process of intercellular movement mitochondria regulated. A new study PLOS Biology reports that ADP released by stressed cells signal triggers HMT.
Язык: Английский
Nature reviews. Immunology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2846 - 2846
Опубликована: Фев. 29, 2024
The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as disease progresses. Bone metastases are a common problem may face, and currently, there no effective drugs treat these individuals. Prostate, breast, lung cancers often spread bone, causing significant disabling health conditions. bone is highly active dynamic tissue considered favorable environment for growth cancer. role osteoblasts osteoclasts in process remodeling way which their interactions change during progression metastasis critical understanding pathophysiology this disease. These create self-perpetuating loop stimulates metastatic cells bone. metabolic reprogramming both microenvironment has serious implications development metastasis. Insight into systemic elements regulate process, well cellular changes occur metastases, discovery cure It crucial explore different therapeutic options focus specifically on malignancy order effectively This review will effects disorders factors like hormones cytokines metastases. We also examine various alternatives available today upcoming advances novel treatments.
Язык: Английский
Процитировано
5
Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Март 7, 2024
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD), and Alzheimer's (AD). Although a great deal energy financial resources have been invested in disease-related research, breakthroughs therapeutic approaches remain elusive. The breakdown cells usually happens together with the onset diseases. However, mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which iron-dependent, causes specific type cell death called ferroptosis, there evidence its involvement pathogenic cascade mechanisms still not well known. present article highlights basic processes underlie ferroptosis corresponding signaling networks. Furthermore, it provides an overview discussion current research on role across variety conditions.
Язык: Английский
Процитировано
5
Biomolecules, Год журнала: 2024, Номер 14(4), С. 483 - 483
Опубликована: Апрель 16, 2024
Obesity, characterized by the excessive accumulation of adipose tissue, has emerged as a major public health concern worldwide. To develop effective strategies for treating obesity, it is essential to comprehend biological properties different tissue types and their respective roles in maintaining energy balance. Adipose serves crucial organ storage metabolism human body, with functions extending beyond simple fat encompass regulation homeostasis secretion endocrine factors. This review provides an overview key characteristics, functional differences, interconversion processes among white (WAT), brown (BAT), beige tissue. Moreover, delves into molecular mechanisms recent research advancements concerning browning WAT, activation BAT, whitening BAT. Although targeting holds promise potential approach obesity treatment, further investigations are necessary unravel intricate features various elucidate pathways governing interconversion. Such endeavors will pave way development more efficient targeted therapeutic interventions fight against obesity.
Язык: Английский
Процитировано
5
Biomaterials Advances, Год журнала: 2024, Номер 160, С. 213861 - 213861
Опубликована: Апрель 15, 2024
Novel strategies employing mechano-transducing materials eliciting biological outcomes have recently emerged for controlling cellular behaviour. Targeted responses are achieved by manipulating physical, chemical, or biochemical modification of material properties. Advances in techniques such as nanopatterning, chemical modification, molecule embedding, force-tuneable materials, and artificial extracellular matrices helping understand mechanotransduction. Collectively, these manipulate sensing regulate signalling cascades including focal adhesions, YAP-TAZ transcription factors, multiple osteogenic pathways. In this minireview, we providing a summary the influence that particularly titanium-based orthopaedic on cells. We also highlight recent complementary methodological developments including, but not limited to, use metabolomics identification active biomolecules drive differentiation.
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 6, 2025
Bone homeostasis depends on a balance between osteoclastic bone resorption and osteoblastic formation. The occurrence, development, control of infections cannot be separated from the regulation immune microenvironment.(1) process metastasis is complex occurs in multiple stages, with also involved.(2) latest research shows that PANoptosis involved variety inflammatory disorders through amplifying cascades. (https://pmc.ncbi.nlm.nih.gov/articles/PMC10730955/) This topic aims to reveal mechanism infection tumor progression an perspective, which expected provide promising theoretical support for corresponding treatments.Osteomyelitis condition caused by infectious microorganisms result progressive destruction loss. Early accurate diagnosis essential minimizing unnecessary treatments, improving patient outcomes, reducing both time financial expenditures.(3, 4) use Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) has emerged as revolutionary imaging technique integrates anatomical functional metabolic data, demonstrating acceptable diagnostic accuracy various diseases. (https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1378409/full)Spinal tuberculosis one most common types extrapulmonary tuberculosis. Simultaneous Single-Position Oblique Lateral Interbody Fusion (SP-OLIF) was efficient minimally invasive protocol single-level lumbar tuberculosis, facilitating earlier clinical improvement, decreased blood loss, operative hospital stay compared posterior-only approach.(5) Modified (M-OLIF) requiring multilevel fixation, reduced operation iatrogenic trauma, improvement traditional combined surgery. (https://josr-online.biomedcentral.com/articles/10.1186/s13018-023-03959-3)Osteosarcoma (OS) prevalent malignant tumor, associated poor prognosis. It features hyperactivated oxidative phosphorylation (OXPHOS) pathway, wherein nuclear receptor RORγ induces expression PGC-1β physically interacts it, thus enhancing OXPHOS program upregulation respiratory chain component genes.(6) Consequently, may represent potential therapeutic target OS. Research indicates CD80 expressed CD62L+ myeloid dendritic cells CD28−CD4−CD8− T-cell absolute counts are positively correlated OS, while CD20 CD24+CD27+ B IgD+CD38 exert negative influence osteosarcoma. These findings suggest circulating cell subtypes can have promoting protective effects osteosarcoma risk. (https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1381212/full)Current methodologies predicting survival primary lymphoma (PBL) spine inadequate. Kaplan-Meier analysis performed assess overall rates these patients, revealing 68% 63% at 3-year 5-year marks, respectively. Furthermore, novel conditional survival-based nomogram model successfully established validated, enabling real-time dynamic estimation. (https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1356947/full)Bone frequently affected organ advanced cancers, including lung, breast, prostate, colorectal, melanoma. Numerous studies close relationship microenvironment, particularly microenvironment.(7) documented spatiotemporal interaction osteoclasts, phenomenon referred tumor-associated osteoclast "tumasteoclast," represents subtype osteoclasts found metastases mediated tumor-migrasome-induced cytoplasmic transfer.(8) Additionally, it been demonstrated osteocytes transfer mitochondria metastatic cancer cells, initiating cGAS/STING-mediated antitumor response. Inhibition mitochondrial targeted knockout Rho GTPase 1 (Rhot1) or mitofusin 2 (Mfn2) diminishes immunogenicity, consequently toward matrix.(9) surface undergoes new growth known periosteal reaction response infection, injury, malignancy. serves defense against invasion into bone. A genetically tractable mouse head neck squamous carcinoma (HNSCC) induced depletion accelerates bone.(10) Breast metastasizes bone, resulting osteolytic lesions. In vivo microcomputed tomography (microCT)-based time-lapse morphometry employed alterations (re)modeling, even absence detectable finding suggests elevated (re)modeling serve catalyst lesion formation during early stages metastasis.(11) first case occurring breastfeeding enhances our understanding differential breast (POB), patients presenting atypical symptoms findings, should not underestimated. (https://doi.org/10.3389/fonc.2024.1362024)In conclusion, this Topic presents comprehensive insights cellular molecular mechanisms underlying diseases tumors. targets strategies discussed papers avenues treatment conditions.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 47, С. 83 - 99
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101542 - 101542
Опубликована: Фев. 4, 2025
Immunotherapy has emerged as a hotspot for cancer treatment. However, the response rate of monotherapy remains relatively low in clinical settings. Photothermal therapy (PTT), which employs light energy to ablate tumors, can also activate tumor-specific immune responses. This effect been attributed several studies release damage-associated molecular patterns (DAMPs) triggered by mitochondrial injury. We propose that mitochondria-targeted PTT may better synergize with immunotherapy. Herein, we constructed multifunctional nanoplatform enables photothermal-chemodynamic combination conjugating indocyanine green-thiol (ICG-SH) and mercaptoethyl-triphenylphosphonium (TPP-SH) onto polyvinyl pyrrolidone (PVP)-coated gold-copper nanoparticles (AIT). Upon near-infrared (NIR) irradiation, AIT ablates cells amplifies chemodynamic (CDT), thereby inducing apoptosis tumor. The CDT promotes immunogenic cell death, could checkpoint blockade In bilateral mouse colon model, observed complete eradication light-irradiated primary tumors significant inhibition distant untreated group treated plus anti-PD-1 (αPD-1). found increase serum levels pro-inflammatory factors, including interleukin-6 (IL-6), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), following PTT/CDT/immunotherapy treatment, suggesting effective activation response. enhanced immunogenicity caused αPD-1 treatment resulted efficient antigen presentation, indicated increased infiltration dendritic (DCs) into tumor-draining lymph nodes (LNs). CD8+ T compared alone. Hence, mitochondria-targeting represents an strategy potentiate photothermal, chemodynamic, therapies metastatic cancer.
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 23, 2025
Язык: Английский
Процитировано
0
Immunology Letters, Год журнала: 2025, Номер 274, С. 106992 - 106992
Опубликована: Март 6, 2025
Язык: Английский
Процитировано
0