Analytical Chemistry,
Год журнала:
2024,
Номер
96(49), С. 19220 - 19229
Опубликована: Ноя. 27, 2024
Vanadate
has
become
an
important
indicator
for
environmental
testing
due
to
its
high
toxicity,
mobility,
and
difficulty
in
degradation.
In
addition,
depending
on
dynamic
aggregation,
analyzing
vanadate
is
not
a
single
content
test;
it
needs
further
morphological
analysis.
Previous
research
tended
construct
functional
platform
with
complicated
procedures
expensive
equipment,
making
difficult
obtain
comprehensive
picture
of
short
time.
Herein,
we
constructed
dual-response
fluorescent
probe
EuTAT@Rh
B
formed
by
Eu
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(47)
Опубликована: Авг. 13, 2024
Abstract
Tuning
full‐color
emission
of
polymers
holds
significant
promise.
However,
preparing
unconventional
luminescence
with
color‐tunability
in
dilute
solution
and
understanding
the
relationship
between
non‐covalent
interactions
luminescent
behavior
remains
a
great
challenge.
We
report
two
emitters
(P1
P2)
incorporating
tetracoordinate
boron.
The
P1
non‐conjugated
D‐π‐A
structure,
exhibited
red
delayed
fluorescence
at
645
nm
quantum
yield
9.15
%
aggregates.
Notably,
wavelength
can
be
tuned
from
418
to
588
different
solvent.
Similarly,
P2
also
adjusted
by
manipulating
solvent
fluorophore.
Experimental
characterization
theoretical
calculations
indicate
that
B←N
bond
electronic
fluorophore
significantly
regulate
equilibrium
electrostatic
potential
(ESP)
intramolecular
O⋅⋅⋅O
P1,
thereby
modulating
its
wavelength.
Additionally,
these
showed
excellent
fluoride
ions
detection.
This
work
provides
new
insights
into
complex
effects
intermolecular
on
properties.
Cytochrome
P450
3A4
(CYP3A4)
is
a
key
mediator
in
xenobiotic
metabolism
and
drug-drug
interactions
(DDI),
developing
orally
active
fluorogenic
substrates
for
sensing
imaging
of
target
enzyme
biological
systems
remains
challenging.
Here,
an
artificial
intelligence
(AI)-driven
strategy
used
to
construct
highly
specific
substrate
CYP3A4
complex
systems.
After
the
fusion
AI-selected
drug-like
fragment
with
CYP3A4-preferred
fluorophore,
three
candidates
are
designed
synthesized.
Among
all
evaluated
candidates,
NFa
exhibits
excellent
isoform-specificity,
ultra-high
sensitivity,
outstanding
spatial
resolution,
favorable
safety
profiles,
acceptable
oral
bioavailability.
Specifically,
excels
at
functional
situ
living
exceptional
endoplasmic
reticulum
(ER)-colocalization
performance
high
while
this
agent
can
also
replace
hCYP3A4
drug-substrates
high-throughput
screening
inhibitors
assessing
DDI
potential
vivo.
With
help
NFa,
novel
inhibitor
(D13)
was
discovered,
its
anti-CYP3A4
effects
assessed
live
cells,
ex
vivo
Collectively,
AI-powered
adapted
highly-specific
substrates,
resulting
first
available
tool
(NFa)
activities,
which
facilitates
CYP3A4-associated
fundamental
investigations
drug
discovery
process.
Molecules,
Год журнала:
2025,
Номер
30(7), С. 1531 - 1531
Опубликована: Март 30, 2025
As
two
significant
indicators
in
the
microenvironment,
hypochlorous
acid
and
viscosity
play
important
roles
multitudinous
physiological
metabolic
processes.
However,
it
is
challenging
to
determine
dynamic
levels
of
living
cells
organisms
because
absence
effective
molecular
tools
that
can
simultaneously
detect
organisms.
Herein,
a
design
strategy
was
presented
fabricate
single
fluorescence
probe
by
using
different
emission
channels.
In
JXR,
TICT-based
4-(2-(5-(dimethylamino)thiophen-2-yl)vinyl)-1-methylpyridin-1-ium-iodide
chromophore
serves
as
energy
acceptor
FRET
process
sensors
for
viscosity.
JXR
showed
large
Stokes
shift,
wide
peak
distance,
high
photostability,
low
toxicity.
could
rapidly,
sensitively,
selectively
emitting
signals.
Importantly,
successfully
applied
track
intracellular
cells.
Meanwhile,
generation
endogenous
hypochlorite
be
observed
JXR.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 22, 2025
Photoacoustic
imaging
(PAI)
is
an
emerging
biomedical
modality
with
promise
as
a
point-of-care
diagnostic.
This
relies
on
optical
excitation
of
absorber
followed
by
production
ultrasound
through
the
photoacoustic
effect,
resulting
in
high
spatial
resolution
depths
centimeter
range.
Herein,
we
disclose
discovery
first
benchmarking
parameter
for
small
molecule
dye
performance
PAI,
which
term
acoustic
loudness
factor
(ALF).
ALF
can
predict
PAI
without
need
access
to
instrumentation
and
be
used
guide
systematic
evaluation
design
strategies
enhance
signal.
Lastly,
demonstrate
that
enhancements
translated
vivo
PAI.
Akin
use
fluorescence
brightness
fluorophore
imaging,
anticipate
will
improved
probes
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Май 5, 2025
Single-component
multi-emissive
materials
with
stimuli-responsive
properties
offer
unique
advantages
in
the
field
of
multicolor-tunable
photoluminescence
(PL).
However,
precisely
modulating
emission
each
component
and
achieving
high-efficiency
present
a
formidable
challenge.
Herein,
we
demonstrate
that
space-confined
charge
transfer
(CT)
turns
on
bright
blue-green-white
initially
faintly
emissive
metal-organic
frameworks
(MOFs)
at
ambient
conditions
through
pressure
treatments.
Pressure
treatments
induce
transition
from
initial
long-range
CT
to
mode,
significantly
amplifying
radiative
transitions.
Furthermore,
CT,
which
occurs
between
mutually
perpendicular
ligands,
influences
spin-orbit
intersystem
crossing.
Precise
tuning
kinetics
via
multi-level
allows
us
modulate
fluorescence-to-phosphorescence
ratio,
target
MOFs.
Our
work
advances
development
smart
PL
unlocks
potential
for
their
application
atmospheric
environments.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 21, 2024
The
fluorescence
high-throughput
screening
method
is
of
importance
for
new
antioxidant
drug
candidate
discovery
the
treatment
serious
hepatorenal
syndrome,
which
displayed
an
obvious
upregulated
peroxynitrite
level.
However,
most
current
ONOO
Chemical Communications,
Год журнала:
2024,
Номер
60(77), С. 10720 - 10723
Опубликована: Янв. 1, 2024
A
novel
approach
was
proposed
to
enhance
the
microviscosity
sensitivity
of
molecular
rotor
probes
by
integrating
flexible
rotators
and
expanded
frameworks,
addressing
crucial
challenge
weakening
in
dilute
solutions
macromolecules.
