Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 24, 2024

Abstract Local therapy strategies still provide only limited success in the treatment of glioblastoma, most frequent primary brain tumor adults, indicating global involvement this fatal disease. To study impact neuroinflammation distant site on clinical course patients with we performed translocator protein (TSPO)-PET newly diagnosed glioma WHO 2 and healthy controls compared signals non-lesion (i.e. contralateral) hemisphere. Back-translation syngeneic glioblastoma mice was used to characterize PET alterations a cellular level. Ultimately, multiplex gene expression analyses served profile immune cells remote brain. Our revealed elevated TSPO-PET contralateral hemispheres controls. Contralateral TSPO associated persisting epilepsy short survival independent phenotype. pinpointed myeloid as source signal increases complex signature comprised joint cell activation immunosuppression regions. In brief, within hemisphere is poor outcome glioblastoma. serves detect who may benefit from immunomodulatory strategies.

Язык: Английский

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Molecular Neurodegeneration, Год журнала: 2024, Номер 19(1)

Опубликована: Сен. 5, 2024

Язык: Английский