Pde4b-regulated cAMP signaling pathway in the AUDGABA-S1TrSst circuit underlies acute-stress-induced anxiety-like behavior

Cell Reports, Год журнала: 2025, Номер 44(2), С. 115253 - 115253

Опубликована: Янв. 30, 2025

Язык: Английский

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Endogenous Regulator of G protein Signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice

Addiction Neuroscience, Год журнала: 2025, Номер unknown, С. 100203 - 100203

Опубликована: Фев. 1, 2025

Язык: Английский

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Corticotropin-Releasing Hormone Neurons in the Central Amygdala Nucleus: An Integrative Hub for Pain, Emotion, and Addiction Neurobiology

Опубликована: Янв. 1, 2025

Язык: Английский

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BNSTGABA Neurons Regulate Autophagy to Alleviate Depression with Gastric Dysfunction Symptoms

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111360 - 111360

Опубликована: Апрель 1, 2025

Язык: Английский

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The hypothalamic MPOA-PVN circuit modulates depressive-like behaviors in a mouse model of postpartum depression

Research, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

Estrogen fluctuations have been implicated in various mood disorders, including perimenopausal and postpartum depression (PPD), likely through complex neural networks. γ-aminobutyric acid-ergic (GABAergic) neurons the medial preoptic area (MPOA) that express estrogen receptor 1 (ESR1) are essential for development expression of depressive-like behaviors ovarian hormone withdrawal (HW) mice. However, precise circuit mechanisms which MPOA GABAergic influence behavior remain incompletely understood. Here, we identified robust projections from to paraventricular nucleus hypothalamus (PVN). In HW mice, chemogenetic activation targeting PVN attenuated behaviors. Conversely, nonhormone (NHW) control mice (which received continuous estrogen), suppression exacerbated Further analyses using quantitative polymerase chain reaction immunostaining arginine vasopressin (AVP) as a key neuropeptide this pathway mouse model. Chemogenetic inhibition AVP significantly alleviated while their NHW worsened These were dependent on neurons. Moreover, receiving input mitigated these Electrophysiological recordings demonstrated directly inhibit Thus, our findings suggest serve downstream effectors via monosynaptic inhibitory signaling regulate Targeting may offer novel therapeutic strategy PPD.

Язык: Английский

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Sexually Dimorphic Cellular Architecture and Neural Circuity of ovBNST Proenkephalin Neurons

Neuroscience Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Язык: Английский

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Corticotropin-releasing hormone neurons in the central Amygdala: An integrative hub for pain, emotion, and addiction neurobiology

Brain Research, Год журнала: 2025, Номер unknown, С. 149753 - 149753

Опубликована: Июнь 1, 2025

Язык: Английский

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Acute stress causes sex-dependent changes to ventral subiculum synapses, circuitry, and anxiety-like behavior

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 3, 2024

Abstract Experiencing a single severe stressor is sufficient to drive sexually dimorphic psychiatric disease development. The ventral subiculum (vSUB) emerges as site where stress may induce adaptations due its sex-specific organization and pivotal role in integration. Using 1-hr acute restraint model, we uncover that causes net decrease vSUB activity females potent, long-lasting, driven by adrenergic receptor signaling. By contrast, males exhibit increase transient corticosterone We further identified sex-dependent changes output the bed nucleus of stria terminalis anxiety-like behavior response stress. These findings reveal striking disease-relevant brain regions following with sex-, cell-type, synapse-specificity contribute our understanding shape stress-related risk. Highlights BS cells are uniquely sensitive Stress cell E/I balance aBNST vivo females, but not

Язык: Английский

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Endogenous Regulator of G protein Signaling 14 (RGS14) suppresses cocaine-induced emotionally motivated behaviors in female mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 15, 2024

Addictive drugs hijack the neuronal mechanisms of learning and memory in motivation emotion processing circuits to reinforce their own use. Regulator G-protein Signaling 14 (RGS14) is a natural suppressor post-synaptic plasticity underlying hippocampus. The present study used immunofluorescence RGS14 knockout mice assess role behavioral reward induced by chronic cocaine emotional-motivational circuits. We report that strongly expressed discrete regions ventral striatum extended amygdala wild-type mice, co-expressed with D1 D2 dopamine receptors neurons nucleus accumbens (NAc). Of note, we found upregulated NAc history following acute treatment. significantly increased cocaine-induced locomotor sensitization, as well enhanced conditioned place preference activity RGS14-deficient compared littermates. Together, these findings suggest endogenous suppresses circuits, implicating protective agent against maladaptive neuroplastic changes occur during addiction.

Язык: Английский

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Design, Synthesis, and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH)

Molecules, Год журнала: 2024, Номер 29(15), С. 3647 - 3647

Опубликована: Авг. 1, 2024

Corticotropin-releasing factor (CRF) is a key neuropeptide hormone that secreted from the hypothalamus. It master of HPA axis, which orchestrates physiological and behavioral responses to stress. Many disorders, including anxiety, depression, addiction relapse, others, are related over-activation this system. Thus, new molecules may interfere with CRF receptor binding be value treat neuropsychiatric stress-related disorders. Also,

Язык: Английский

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