Some molecular-genetic determinants of premature aging in women DOI Creative Commons
Е. V. Kudryavtseva, D. A. Berezina, Daniil O. Kornilov

и другие.

Consilium Medicum, Год журнала: 2024, Номер 26(12), С. 809 - 814

Опубликована: Дек. 18, 2024

Background. Accelerated biological aging is associated with age-related diseases and an increased risk of mortality. Genetic predisposition may be important factor in this process. Aim. To determine the significance genetic polymorphisms VDR COL1A1 genes accelerated aging. Materials methods. The study included 100 women aged 20–35 years, divided into groups (Group 1) normal/slow 2) rates. We assessed age using V.P. Voytenko's formula. analyzed were: 283 AG (Bsml), 2 (Fokl), 1546 GT, -1997 CA. Results. (AA) polymorphism was aging, occurring more frequently Group 1 (18% vs 4% 2, p=0.025). CA prevalent (76% 56% 1, p=0.035). A multifactorial model identified combinations that predict or slow accuracy 0.72. Conclusion. plays a significant role Analysis can help identify premature serve as basis for further research development new approaches to prevent diseases.

Язык: Английский

3D Composite SERS Substrate Constructed by Au-Ag core-satellite NPs and Polystyrene Sphere for Ultrasensitive Ratiometric Raman Detection of Cotinine DOI
Gaofeng Wu,

Jian Zhu,

Guojun Weng

и другие.

Talanta, Год журнала: 2025, Номер 289, С. 127742 - 127742

Опубликована: Фев. 14, 2025

Язык: Английский

Процитировано

2
Early-life risk factors for recurrent wheezing in preschool children: A meta-analysis of 15 cohort studies DOI
Kaiwen Zheng, Xiang Wang

Allergy and Asthma Proceedings, Год журнала: 2025, Номер 46(3), С. e98 - e109

Опубликована: Май 1, 2025

Background: Recurrent wheezing (RW) is particularly prevalent in preschool-age children and strongly associated with the future development of asthma. Objective: Because no meta-analysis risk factors for RW comprehensively assess needful. Methods: The research was conducted accordance Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. A comprehensive search English-language studies performed across four medical literature data bases. Subgroup analyses, sensitivity evaluations publication bias were carried out. Multiple cohort included. Stata software Grading Recommendations, Assessment, Development Evaluation (GRADE) used analysis; positive results discussed qualitatively. Results: total 15 that covered 128,065 Some factors, including allergic rhinitis (odds ratio [OR] 4.16 [95% confidence interval {CI}, 1.06-16.33]), family history asthma (OR 2.14 CI, 1.24-3.69]), food allergy 2.25 1.73-2.93]), preterm 1.87 1.36-2.58]), male 1.47 1.17-1.84]), cesarean section 1.36 1.08-1.71]), environmental tobacco smoke 2.15 1.55-2.99]), got results. Conclusion: Risk preschool sought. This provides a new perspective theoretical basis preventing childhood

Язык: Английский

Процитировано

1
Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration DOI Creative Commons

Qiankun Yang,

Xiaoyu Zhu, Li Zhang

и другие.

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 25, 2025

Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker dyslipidemia. However, whether AIP can be used as indicator aging remains unclear. This study aims investigate the relationship between US adult population. 4,471 American adults with age over 20 years National Health Nutrition Examination Survey (NHANES) database were included this study. Biological was assessed by phenotypic acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses interaction tests employed explore association PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) assess potential nonlinear relationships, while mediation analysis utilized identify mediating effects homeostatic model assessment insulin resistance (HOMA-IR). Besides, network pharmacology performed determine mechanisms underlying dyslipidemia-related acceleration. A total participants study, median chronological age, PhenoAge PhenoAgeAccel for overall population 49 (35-64) years, 42.85 (27.30-59.68) - 6.92 (- 10.52 -2.46) respectively. In fully model, one unit increase correlated 1.820-year (β = 1.820, 95% CI: 1.085-2.556), which more pronounced among individuals being female, diabetic hypertensive. RCS revealed PhenoAgeAccel, inflection point identified at -0.043 via threshold saturation effect analysis. demonstrated positive correlation both before 6.550, 5.070-8.030) after 3.898, 2.474-5.322) point. Additionally, HOMA-IR found mediate 39.21% Finally, INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, SERPINE1 core targets aging, functionally linked key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. CONCLUSIONS: An elevated notably positively accelerated suggesting that may serve predictor evaluate

Язык: Английский

Процитировано

1
Associations of daily eating frequency and nighttime fasting duration with biological aging in National Health and Nutrition Examination Survey (NHANES) 2003–2010 and 2015–2018 DOI Creative Commons
Xuanyang Wang,

Jia Zhang,

Xiaoqing Xu

и другие.

International Journal of Behavioral Nutrition and Physical Activity, Год журнала: 2024, Номер 21(1)

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

3
Smoking-attributable neurological health loss: age-specific burden and health disparities DOI
Yingjie Zhao, Fei Lu

Journal of Neurology Neurosurgery & Psychiatry, Год журнала: 2025, Номер unknown, С. jnnp - 335536

Опубликована: Фев. 12, 2025

Background Smoking is a significant risk factor for neurological disorders, yet its global impact on these conditions remains underexplored. Methods Using Global Burden of Diseases 2021 data, we analysed trends in age-standardised disability-adjusted life-years (DALYs) and deaths attributable to smoking from 1990 three disorders: stroke, Alzheimer’s disease other dementias, Multiple Sclerosis. Socioeconomic disparities were assessed using the lope index inequality relative concentration index. Bayesian age-period-cohort models employed forecast smoking-attributable burden through 2050. Results Between 2021, annual DALYs death rates slightly declined by −1.93% −1.92%, respectively, but absolute numbers continued rise, 26.10 million 30.18 0.93 1.15 deaths. Older adults (aged 60 above) experienced greatest burden, contributing 58.15% 75.57% 2021. Smoking-attributable stroke was increasingly concentrated low sociodemographic regions, whereas dementias multiple sclerosis more pronounced socioeconomically advantaged particularly sclerosis. Conclusions This study identified an age-specific widening disorders smoking, with older disproportionately experiencing escalating impact. Targeted prevention equitable healthcare access tailored are critical mitigating health loss.

Язык: Английский

Процитировано

0
The impact of in utero tobacco exposure on smoking behaviors, cardiovascular disease risk and all-cause mortality in adulthood: A UK Biobank study DOI Creative Commons

Yanxu Zheng,

Xinyu Xiong, Jing Bao

и другие.

Current Research in Toxicology, Год журнала: 2025, Номер 8, С. 100226 - 100226

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
The association between biological aging markers and valvular heart diseases DOI Creative Commons

X Z Liu,

Da Luo,

Zheng Hu

и другие.

Journal of Zhejiang University (Medical Sciences), Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

To analyze the association between biological aging markers phenotypic age and acceleration valvular heart diseases. Research subjects met inclusion exclusion criteria were selected from UK Biobank 2006 to 2010. The calculated. of with diseases was analyzed Cox multivariate analysis, sensitivity analysis conducted by removing missing values subgroup analysis. predictive accuracy for using receiver operating characteristic (ROC) curves, a clinical decision curve generated based on logistic regression. A total 411 687 included in study, among whom there 14 258 patients overall median follow-up time 12.80 years, non-rheumatic aortic valve (n=5238), mitral (n=4558), tricuspid (n=411) 12.82 12.83 years 12.84 respectively. After adjusting demographic factors (gender, race, education, Townsend deprivation Index, Dietary Approaches Stop Hypertension score), anthropometric (body mass index), lifestyle (smoking, alcohol consumption), hypertension hyperlipidemia, showed independent risk diseases, including (phenotypic age: corrected HR=1.04, P<0.01; acceleration: HR=1.03, P<0.01), which also confirmed ROC curves that compared acceleration, had higher stronger practicality predicting diseases; single indicator, combination two indicators are Compared has greater advantage is more suitable

Язык: Английский

Процитировано

0
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study DOI Creative Commons
X M Shi,

YiNi Wang,

Fei Yang

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Early-life smoking, cardiovascular disease risk, and the mediating role of DNA methylation biomarkers of aging DOI Creative Commons

Chang Sheng,

Rui Zhou, Hongcai Wang

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 29, 2025

Early-life smoking is linked to biological aging and chronic diseases, yet its specific relationship with cardiovascular disease (CVD) risk the role of DNA methylation biomarkers as potential mediators that remain underexplored. In this study, we analyzed data from 2345 participants in National Health Nutrition Examination Survey (NHANES; 1999-2002). status was assessed on basis age initiation (ASI) categorized into three periods (SIPs): childhood (5-14 years), adolescence/adulthood (> 14 never smoked. (DNAm PhenoAge, DunedinPoAm, HorvathTelo) were measured, CVD outcomes determined via self-reported, physician-confirmed diagnoses. Multivariate logistic regression causal mediation analyses performed assess associations between SIP explore mediating effects those associations. Earlier more strongly associated an increased developing CVD, showing highest (OR = 1.95, 95% CI: 1.15-3.29; P 0.013). Furthermore, independently (1-year increase DNAm PhenoAge: OR 1.03, 1.01-1.05, < 0.001; 0.1-unit DunedinPoAm: 1.19, 1.00-1.40, 0.05; 1-kb HorvathTelo: 0.57, 0.34-0.96, 0.05). Subgroup analysis revealed association early-life stronger among individuals without household exposure (P for interaction 0.035). Moreover, compared status, later correlated delayed epigenetic aging, indicated by lower PhenoAge (β=-0.02, -0.03--0.01, 0.01), slower DunedinPoAm (β=-0.01, -0.01--0.01, 0.001), longer HorvathTelo (β 0.01, 0.01-0.01, 0.001). Mediation significantly mediated risk, accounting 6% total effect (ASI: ACME=-0.000100, 0.010; SIP: ACME 0.004796, 0.022). risk. partially mediates relationship, suggesting a target prevention. these findings highlight need early prevention reduce

Язык: Английский

Процитировано

0
Adherence to EAT-Lancet diet, biological aging and life expectancy in the UK Biobank: a cohort study DOI

Yang-Wei Cai,

Jing‐Wei Gao, Maoxiong Wu

и другие.

American Journal of Clinical Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0