Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes

JAMA Network Open, Год журнала: 2025, Номер 8(5), С. e259960 - e259960

Опубликована: Май 13, 2025

Importance Exposure to high altitudes elicits multiple adaptive mechanisms that intricately impact the entire body, causing deleterious health outcomes. However, high-altitude exposure effects on accelerated aging and aging-related changes remain uncertain. Objective To comprehensively assess associations of with overall related provide insights into treatment prevention aging-associated deficits in populations living areas. Design, Setting, Participants This population-based cross-sectional study used data from 2 prospective studies Western China: West China Natural Population Cohort (WCNPCS) Health Aging Trend (WCHAT). The WCNPCS cohort was constructed May 2019 June 2021. Data were collected participants aged 18 years older 4 populous regions (Mianzhu, Longquan, Pidu, Ganzi) Sichuan Province. WCHAT initiated 2018 recruited 50 various (Sichuan, Yunnan, Guizhou, Xinjiang). selected via sequential cluster sampling permanent residents participating community. for present analyzed between March October 2024. participants’ determined using global Shuttle Radar Topography Mission based residential addresses. High-altitude areas refer greater than or equal 1500 m (4921 feet) above mean sea level. Main Outcomes Measures Biological (BA) acceleration (AA) measured through Klemera–Doubal Age (KDM-BA) PhenoAge methods. Multidimensional metrics questionnaire, measurement, self-report. Results A total 9846 (mean [SD] age, 55.73 [11.06] years; 6730 women [68.35%]) 3593 62.27 [8.40] 2253 [62.71%]) included. at presented increased KDM-BA by 0.85 0.71 cohort. results similar, even larger effect sizes (WCNPCS, β, 2.08 95% CI, 1.77-2.39 WCHAT, 2.23 1.91-2.54 years). association biologically particularly pronounced among smokers. Associations multidimensional also observed. Conclusions Relevance These findings suggest extended periods may hasten BA contribute onset illnesses. Implementing public interventions individuals residing aid alleviating disease burden within these communities.

Язык: Английский

---

Association of proBNPage with all-cause and cardiovascular mortality among US adults: an analysis of data from the National Health and Nutrition Examination Survey

BMJ Open, Год журнала: 2025, Номер 15(5), С. e093052 - e093052

Опубликована: Май 1, 2025

Objective Biological age assessed by the Klemera and Doubal method (KDM) phenotypic (PhenoAge) was considered as a marker for ageing-related outcomes because it reflects different aspects of biological ageing health, which are associated with increased risk death. proBNPage based on N-terminal pro-B-type natriuretic peptide (NT-proBNP) is novel index estimation. However, independence its relationship clinical from established factors, KDM or PhenoAge remains uncertain. Their identification could provide valuable information to prognosis. Design, setting participants This study analysed data general population included in National Health Nutrition Examination Survey (NHANES). Participants who took part cross-sectional survey 1999 2004 were included, all-cause well cardiovascular mortality recorded (up 31 December 2019). Outcome measures All-cause outcomes. Clinical factors collected, estimated proBNPage, PhenoAge. Cox proportional hazards models used determine between adjustment other indexes. Restricted cubic spline (RCS) analysis multivariate regressions performed examine whether there non-linear Results A total 9 925 this study. The association remained significant after adjusting including NT-proBNP (for mortality, HR 1.14; 95% CI 1.10 1.17; 1.20; 1.14 1.27). Similar results obtained plus 1.31; 1.22 1.41; 1.21; 1.11 1.28) 1.16 1.28; 1.35; 1.24 1.47). These findings confirmed most subgroups. observed an inflection point. Conclusions positive After estimation indices (KDM PhenoAge), significantly mortality. remain similar further NT-proBNP. suggest that useful surrogate

Язык: Английский

---

Associations of daily eating frequency and nighttime fasting duration with biological aging in National Health and Nutrition Examination Survey (NHANES) 2003–2010 and 2015–2018

International Journal of Behavioral Nutrition and Physical Activity, Год журнала: 2024, Номер 21(1)

Опубликована: Сен. 19, 2024

Язык: Английский

---

Association of night shift work and biological ageing: the mediating role of body mass index

Age and Ageing, Год журнала: 2024, Номер 53(11)

Опубликована: Ноя. 1, 2024

Abstract Background We aimed to examine whether current and lifetime night shift work is associated with accelerated biological ageing the potential role of body mass index (BMI) in mediating association. Methods Data were sourced from UK Biobank cohort. This study included participants who reported detailed information on their schedule had complete data calculate PhenoAge. The outcome interest was ageing, measured by PhenoAge acceleration. Multivariable linear regression models conducted test relationship between ageing. Mediation analyses performed. Results Of 182 064 included, mean age 52.6 years, 51.1% male. After adjustment for chronological sex, compared day workers, workers without shift, irregular permanent 0.59-, 0.87- 1.30-year increase respectively (P trend <.001). Considering schedule, worked shifts >10 years >8 each month showed increased acceleration [>10 years: β = 0.54, 95% confidence interval (CI) 0.29–0.79; times/month: 0.29, CI 0.07–0.50]. mediation analysis that BMI mediated associations 36%–53%. Conclusions Our findings highlight interventions appropriate schedules weight management which may slow process ultimately reduce burden age-related diseases.

Язык: Английский

---

Association of early-life factors with biological age acceleration and the mediating effect of social environment risks in middle-aged and older adults

Age and Ageing, Год журнала: 2024, Номер 53(12)

Опубликована: Ноя. 28, 2024

Adverse early-life events influence the health with ageing throughout life course. However, effects of combined risks on acceleration in adults and roles social environment remain unknown.

Язык: Английский

---

Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life

Innovation in Aging, Год журнала: 2024, Номер 8(9)

Опубликована: Янв. 1, 2024

Abstract Background and Objectives Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors leukocyte TL; however, the findings were far from consistent. Research Design Methods We evaluated relationship combined leukocytes TL in middle late using data UK Biobank. The (eg, maternal smoking, breastfeeding, birth weight, comparative body size height to peers at age 10) measured. regression coefficients (β) 95% confidence interval (CI) applied assess link adulthood. Flexible parametric survival models incorporated calculate expectancy. Results Exposure lack low shorter compared 10 identified be associated with older according large population-based study 197 504 participants. Individuals who experienced more than 3 adverse had shortest (β = −0.053; CI −0.069 −0.038; p < .0001), well an average 0.54 years loss 45 0.49 60, those not exposed any risk factors. Discussion Implications Early including non-breastfed, later life. In addition, increased number aforementioned was a greater likelihood adulthood, reduced

Язык: Английский

---

The Impact of In Utero Tobacco Exposure on Cardiovascular Disease Risk and All-cause Mortality in Adulthood: a UK Biobank Study

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 20, 2024

Abstract Aim The negative impacts of in utero tobacco exposure (IUTE) on cardiovascular disease (CVD) have been insufficiently described. This study aims to assess the association between IUTE and risks CVD incidence all-cause mortality, discuss inter-group difference based genetic susceptibility smoking behaviors after birth, explore potential mediating factors. Methods Utilizing a total 375,024 participants from UK Biobank, outcomes include myocardial infarction, stroke, chronic ischemic heart disease, nonrheumatic aortic valve disorders, cardiomyopathy, failure, atherosclerosis, aneurysm dissection, mortality. Results During median follow-up period 14.6 years, 50,434 cases were recorded. was significantly associated with increased (HR 1.10, 95% CI 1.08-1.12) mortality 1.11, 1.09-1.14). Interaction effects IUTE, risk scores for observed significant (P interaction < 0.005). results cross-sectional revealed positive birth (OR 1.08, 1.06-1.09). Mediation analysis indicated that (Proportion = 12.40%, P 0.001) HDL-c levels 14.20%, partially mediated IUTE-CVD relationship. Conclusions demonstrated individuals higher developing CVD, multifaceted influence this correlation. These findings underscore importance mothers avoiding during pregnancy mitigate adverse their offspring.

Язык: Английский

---

Causal relationships between basal metabolic rate and epigenetic age acceleration: bidirectional Mendelian randomization and mediation analysis

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Background Basal metabolic rate (BMR) reflecting the body's energy expenditure at rest, may be a crucial indicator of accelerated aging. However, there is lack evidence for causal effect BMR on We aimed to apply Mendelian randomization (MR) and mediation analysis explore relationships between epigenetic age acceleration. Method Genetic variants linked (GrimAge, PhenoAge, HannumAge HorvathAge) acceleration were extracted from genome-wide association study datasets. MR primarily utilizes Inverse variance weighted (IVW), followed by range sensitivity analyses validate robustness our findings. Results The univariable demonstrated significant GrimAge (IVW: Beta 0.38 [95% CI 0.12 0.64]), PhenoAge accelerations 0.91 [95%CI 0.67 1.45]), but not in reverse direction. In multivariate adjusting body mass index (BMI), hypertension, type 2 diabetes mellitus (T2D), physical activity, smoking, alcohol intake frequency, total bioavailable testosterone levels, we found that effects both dependent BMI, also T2D, levels Mediation indicated 7.24%, 16.29%, 6.95%, 5.36% was mediated activity intake. Conclusion A positive unidirectional acceleration, which BMI.

Язык: Английский

---

High exposure to carrageenan in young mice may impair behavior, immunity, redox and inflammatory states throughout the aging process

Food Research International, Год журнала: 2024, Номер 197, С. 115143 - 115143

Опубликована: Сен. 27, 2024

Язык: Английский

---

Some molecular-genetic determinants of premature aging in women

Consilium Medicum, Год журнала: 2024, Номер 26(12), С. 809 - 814

Опубликована: Дек. 18, 2024

Background. Accelerated biological aging is associated with age-related diseases and an increased risk of mortality. Genetic predisposition may be important factor in this process. Aim. To determine the significance genetic polymorphisms VDR COL1A1 genes accelerated aging. Materials methods. The study included 100 women aged 20–35 years, divided into groups (Group 1) normal/slow 2) rates. We assessed age using V.P. Voytenko's formula. analyzed were: 283 AG (Bsml), 2 (Fokl), 1546 GT, -1997 CA. Results. (AA) polymorphism was aging, occurring more frequently Group 1 (18% vs 4% 2, p=0.025). CA prevalent (76% 56% 1, p=0.035). A multifactorial model identified combinations that predict or slow accuracy 0.72. Conclusion. plays a significant role Analysis can help identify premature serve as basis for further research development new approaches to prevent diseases.

Язык: Английский

---