Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells
Current Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Advanced microfluidic systems with temperature modulation for biological applications
Biomicrofluidics,
Год журнала:
2025,
Номер
19(3)
Опубликована: Май 1, 2025
Recent
advances
in
microfluidic
technology
have
shown
the
importance
of
precise
temperature
control
a
wide
range
biological
applications.
This
perspective
review
presents
comprehensive
overview
state-of-the-art
platforms
that
utilize
thermal
modulation
for
various
applications,
such
as
rapid
nucleic
acid
amplification,
targeted
hyperthermia
cancer
therapy,
and
efficient
cellular
lysis.
We
detail
heating
mechanisms-including
nanoparticle-driven
induction,
photothermal
conversion,
electrothermal
approaches
(both
external
on-chip)-and
discuss
how
they
are
integrated
within
lab-on-a-chip
systems.
In
parallel,
advanced
multi-modal
sensing
methods
microfluidics,
ranging
from
conventional
sensors
to
cutting-edge
quantum-based
techniques
using
nanodiamond
nitrogen-vacancy
centers
suspended
microchannel
resonators,
highlighted.
By
integrating
capabilities
into
these
platforms,
broader
applications
enabled,
including
single-cell
analysis,
metabolic
profiling,
scalable
diagnostics.
Looking
ahead,
overcoming
challenges
system
integration,
scalability,
cost-effectiveness
will
be
essential
harnessing
their
full
potential.
Future
developments
this
field
expected
drive
evolution
technologies,
ultimately
enabling
breakthroughs
precision
medicine
high-throughput
biomedical
Язык: Английский
Cyanobacteria newly isolated from marine volcanic seeps display rapid sinking and robust, high-density growth
Applied and Environmental Microbiology,
Год журнала:
2024,
Номер
90(11)
Опубликована: Окт. 29, 2024
ABSTRACT
Cyanobacteria
are
photosynthetic
organisms
that
play
important
roles
in
carbon
cycling
and
promising
bioproduction
chassis.
Here,
we
isolate
two
novel
cyanobacteria
with
4.6Mbp
genomes,
UTEX
3221
3222,
from
a
unique
marine
environment
naturally
elevated
CO₂.
We
describe
complete
genome
sequences
for
both
isolates
and,
focusing
on
3222
due
to
its
planktonic
growth
liquid,
characterize
biotechnologically
relevant
biomass
characteristics.
outpaces
other
fast-growing
model
strains
solid
medium.
It
can
double
every
2.35
hours
liquid
medium
grows
high
density
(>31
g/L
dry
weight)
batch
culture,
nearly
of
Synechococcus
sp.
PCC
11901,
whose
high-density
was
recently
reported.
In
addition,
sinks
readily,
settling
more
quickly
than
strains,
suggesting
favorable
economics
harvesting
biomass.
These
traits
may
make
compelling
choice
dioxide
removal
(CDR)
Overall,
find
bio-prospecting
environments
CO₂
uncover
CO₂-metabolizing
IMPORTANCE
provide
potential
avenue
biomanufacturing
combatting
climate
change
via
high-efficiency
sequestration.
This
study
identifies
isolated
geochemical
describes
their
behavior
biochemical
composition.
appear
tractable
research
model,
cultures
made
publicly
available
alongside
information
about
culture
maintenance.
Application
these
sequestration
and/or
is
discussed,
including
unusual,
rapid
characteristics
the
scaled
culture.
Язык: Английский
Constant surface area-to-volume ratio during cell growth as a design principle in mammalian cells
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 4, 2024
ABSTRACT
All
cells
are
subject
to
geometric
constraints,
such
as
surface
area-to-volume
(SA/V)
ratio,
that
impact
cell
functions
and
force
biological
adaptations.
Like
the
SA/V
ratio
of
a
sphere,
it
is
generally
assumed
decreases
size
increases.
Here,
we
investigate
this
in
near-spherical
mammalian
using
single-cell
measurements
mass
proteins,
well
imaging
plasma
membrane
morphology.
We
find
remains
surprisingly
constant
grow
larger.
This
observation
largely
independent
cycle
amount
growth.
Consequently,
growth
results
increased
folding,
which
simplifies
cellular
design
by
ensuring
sufficient
area
for
division,
nutrient
uptake
deformation
at
all
sizes.
Язык: Английский